Timed-release capsules

Timed-release capsules-These dosage forms gradually release the active medication so that the total daily dosage may be administered in 1 to 3 doses. These products are not necessarily interchangeable. If patients are switched from one brand to another, closely monitor their theophylline serum levels. 

To avoid the side effects of sulfapyridine, various preparations to target 5-ASA directly to sites of disease have been formulated. Also known as mesalamine, 5-ASA has been formulated in oral forms (Pentasa, Asacoi). Pentasa is a time-release capsule that releases the drug throughout the GI tract. Asacoi is a pH-dependent-release preparation that delivers drug to the distal small bowel and colon. The response of ulcerative colitis to this formulation appears to be identical to that seen with sulfasalazine. Mesalamine can also be administered as a suppository (Canasa) or enema (Rowasa) for distal colonic disease. 

Oral 0.125, 0.25 mg tablets 0.375 mg timed-release capsules 0.125 mg/5 mL oral elixir and solution Parenteral 0.5 mg/mL for injection Ipratropium (generic, Atrovent)... 

Roche, Timothy. The Potent Perils of a Miracle Drug. Time, vol. 157, January 8, 2001, p. 47. Describes the emergence of OxyContin, the opiate painkiller that is becoming one of the most widely abused prescription drugs. The time-release capsules are broken open and the drug can then be snorted or injected, producing an effect not unlike heroin. Federal au-... 

In 1952, Smith, Kline and French introduced the stimulant Dexedrine (dextroamphetamine sulfate) for narcolepsy in the United States. It was manufactured as a Spansule, the first time-release capsule, which gradually released the drug over a period of time. 

Slow-release capsules are also available. However, the results of a review of 10 studies that investigated the effectiveness of melatonin for treating jet lag indicated that time-release capsules are not effective for treating jet lag. 

Capsules 25mg and 50mg Time Release Capsules 75mg Injection l.Omg/ml Ophthalmic Suspension lOmg/ml Oral Suspension lOmg/ml Suppositories 50mg and lOOmg... 

Figure 2.4 The figure shows an image at 1800 nm of microspheres that are the constituents of a time-release capsule. Because there is no notable spectral difference between the spheres at this wavelength, there is no contrast between the individual spheres. This image is comparable to a visible image of the samples. The FOV (12.8 x 10.2 mm) encompasses 135 of the microspheres.

Pure caffeine is sold in most drugstores for much more than it is worth in clever disguises meant to suggest powerful amphetamines. For example, a product called Caffedrine in large, green and white time-release capsules looks just like pharmaceutical Dexamyl. No doubt some people who buy it resell it on the black... 

Acetazolamide is readily absorbed from the gastrointestinal tract after oral administration. After ingestion of acetazolamide tablets, the drug attains peak plasma levels within 2 to 4 hours. Peak levels are maintained for 4 to 6 hours. Drug levels are higher after acetazolamide tablets are ingested than after an equivalent dose of the sustained-release formulation. The time-release capsules produce maximum drug levels in 3 to 4 hours, and levels of 10 mg/ml are maintained for approximately 10 hours. 

Inactive Ingredient Also called the excipient. This is a substance that does not cause the pharmaceutical response but helps delivers the medication. Inactive ingredients are used as fillers to give the medication shape and size and assist in the delivery of medication, such as the coating around tiny particles of a time-release capsule. 

Capsules These are administered using the oral route. Capsules must be taken whole and not crushed because medication in the capsule is enteric-coated for timed release. Capsules can be opened and the medication mixed with the food depending on the medication. 

Cat s claw is available in 300-mg capsules to be taken three times daily 1000-mg time-release capsules to be taken once daily liquid concentrate (8 1 in 20% alcohol) to be diluted in water and taken one to three times daily and bark to be used for tea. 

Case 1. A 55-year-old housewife with reair-rent rhinitis had taken two medications on a regular basis for 10 years. The first of these was a timed-release capsule containing brompheniramine maleate, 12 mg, phenylephrine hydrochloride, 15 mg, and phenylpropanolamine hydrochloride, 15 mg. She took 2 tablets a day for 8 years, and then took 2 tablets every other day. Tlie other tablets contained phenindamine tartrate, 10 mg, and phenylephrine hydrochloride, 5 mg. She took 4-8 of these tablets weekly. Three months before the onset of abnormal movements, she took fluphe-nazine hydrochloride in a dose of 1 mg daily for... 

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