Sister-chromatid exchange production

Ray JH, Altenburg JL, Jacobs MM. 1978. Effects of sodium selenite and methyl methanesulphonate or N-hydroxy-2-acetylamino-fluorescence co-exposure on sister chromatid exchange production in human blood cultures. Mutat Res 57 359-368. 

The effect of thiourea on cis-DDP sister-chromatid exchange production in V79. Conditions are outlined in Fig. 11 legend. 

Brat SV, Williams GM. 1982. Hepatocyte-mediated production of sister chromatid exchange in cocultured cells by acrylonitrile Evidence for extra cellular transport of a stable reactive intermediate. Cancer Lett 17 213-216. 

Positive results in the in vivo sister chromatid exchange (SCE) assay indicate that the test substance induces reciprocal chromatid interchanges in the bone marrow or lymphocytes of the test species. SCEs represent the interchange of DNA replication products at apparently homologous loci. The exchange process presumably involves DNA breakage and reunion, although httle is known about its molecular basis. 

Response Surface Analysis Structure-Activity Relationship Superfund Amendments and Reauthorization Act Scientific Committee on Consumer Products Sister Chromatid Exchange... 

Andersen O. 1983. Effects of coal combustion products and metal compounds on sister chromatid exchange (SCE) in a macrophage cell line. Environ Health Perspect 47 239-253. 

Kelsey, K.T., Wiencke, J.K., Ward, J., Bechtold, W. Fajen, J. (1995) Sister-chromatid exchanges, glutathione S-transferase theta deletion and cytogenetic sensitivity to diepoxybutane in lymphocytes from butadiene monomer production workers. Mutat. Res., 335, 267-273... 

Brambilla. G. Sciaba. L.. Faggin, P, Maura, A., Marinari. U.M., Ferro. M. Esterbauer. H. (1986) Cytotoxicity. DNA fragmentation and sister-chromatid exchange in Chinese hamster ovary cells exposed to the lipid peroxidation product 4-hydroxynonenal and homologous aldehydes. Mutat. Res.. 171. 169-176... 

Natarajan, A.T., Simons, J.W.I.M., Vogel, E.W. van Zeeland, A.A. (1984) Relationship between cell killing, chromosomal aberrations, sister-chromatid exchanges and point mutations induced by monofunctional alkylating agents in Chinese hamster cells. A correlation with different ethylation products in DNA. Mutat. Res., 128, 31-40... 

Cells of patients with Bloom syndrome (BS) have many chromosome breaks and a high frequency of sister chromatid exchanges, perhaps in an effort to correct these breaks. The body is small but well-proportioned.kk A somewhat similar disease, the Werner syndrome (WS), is associated with premature aging.11 The Bloom s protein BLM and the WS gene product WRN are both helicases related to E.coli RecQ. Protein BLM colocalizes with replication protein A as discrete foci in the meiotic synaptonemal complex.1 3 Protein WRN also seems to be associated with DNA replication. Defects... 

Genotoxic Effects. No increases in micronuclei or sister chromatid exchanges were observed in varnish production workers exposed to both 2-ethoxyethanol and 2-butoxyethanol (Sohnlein et al. 1993). Postshift biological monitoring for the acetic acids in urine indicated that urinary levels of 2-ethoxyacetic... 

Acute effects of ethylene oxide and its by-product ethylene chlorhydrin (CH2CICH2OH), formed by reaction with chloride ions, include symptoms of nausea, dizziness, and signs of mental disturbance. Ethylene chlorhydrin may also cause kidney and liver degeneration. The most serious effects of both substances may lead to cancer. Exposure to ethylene oxide induces irreversible chromosomal aberrations (sister chromatid exchange) and other ptecancerous changes in the peripheral lymphocytes. 

The effect of NDGA on the production of sister-chromatid exchanges and on the level of the mitotic index in cultured human lymphocytes and in mouse bone marrow cells in vivo was evaluated by Madrigal Bujaidar et al. [311], and they observed that in both models NDGA produced genotoxic and cytotoxic effects. In a later study [312], the same author observed... 

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