Sister-chromatid exchange production cells

Brat SV, Williams GM. 1982. Hepatocyte-mediated production of sister chromatid exchange in cocultured cells by acrylonitrile Evidence for extra cellular transport of a stable reactive intermediate. Cancer Lett 17 213-216. 

Andersen O. 1983. Effects of coal combustion products and metal compounds on sister chromatid exchange (SCE) in a macrophage cell line. Environ Health Perspect 47 239-253. 

Brambilla. G. Sciaba. L.. Faggin, P, Maura, A., Marinari. U.M., Ferro. M. Esterbauer. H. (1986) Cytotoxicity. DNA fragmentation and sister-chromatid exchange in Chinese hamster ovary cells exposed to the lipid peroxidation product 4-hydroxynonenal and homologous aldehydes. Mutat. Res.. 171. 169-176... 

Natarajan, A.T., Simons, J.W.I.M., Vogel, E.W. van Zeeland, A.A. (1984) Relationship between cell killing, chromosomal aberrations, sister-chromatid exchanges and point mutations induced by monofunctional alkylating agents in Chinese hamster cells. A correlation with different ethylation products in DNA. Mutat. Res., 128, 31-40... 

Cells of patients with Bloom syndrome (BS) have many chromosome breaks and a high frequency of sister chromatid exchanges, perhaps in an effort to correct these breaks. The body is small but well-proportioned.kk A somewhat similar disease, the Werner syndrome (WS), is associated with premature aging.11 The Bloom s protein BLM and the WS gene product WRN are both helicases related to E.coli RecQ. Protein BLM colocalizes with replication protein A as discrete foci in the meiotic synaptonemal complex.1 3 Protein WRN also seems to be associated with DNA replication. Defects... 

The effect of NDGA on the production of sister-chromatid exchanges and on the level of the mitotic index in cultured human lymphocytes and in mouse bone marrow cells in vivo was evaluated by Madrigal Bujaidar et al. [311], and they observed that in both models NDGA produced genotoxic and cytotoxic effects. In a later study [312], the same author observed... 

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