Severe respiratory insufficiency

If pafienf has severe chronic hypercapnia, myasfhenia gravis, severe respiratory insufficiency, sleep apnea, or severe hepafic insufficiency... 

Confirmatory tests for IMS include persistent inhibition of AChE, decreasing response on electromyography, and necrotizing myopathy on muscle biopsy. In most instances, recovery from IMS is complete, though a few deaths have been reported due to severe respiratory insufficiency. Only a few IMS patients have developed delayed neuropathy. The risk of death in IMS is as dangerous as it is in the cholinergic crisis phase. Due to development of severe respiratory distress, tracheostomy is recommended for ventilatory support. Patients may remain on a respirator for 7 days or more. In conclusion, prolonged inhibition of... 

In Duchenne, the first symptom is muscle weakness in the early years of life which gradually worsens so that patients are unable to walk by the age of 10 years. Death from cardiac or respiratory insufficiency usually occurs before the age of 25. In Becker type, weakness and wasting becomes apparent between 5 and 25 years but, although severely disabled, patients can survive to a normal age. 

Inhalation of mercury vapor may produce a metal fume fever-like syndrome, including chills, nausea, general malaise, tighmess in the chest, and respiratory symptoms. High concentrations cause corrosive bronchitis and interstitial pneumonitis. In the most severe cases, the patient will succumb because of respiratory insufficiency. In one episode involving four workers, it was estimated that mercurial pneumonitis resulted from exposure for several hours to concentrations ranging between 1 and 3mg/m. ... 

IR concentrated oral solution and tablets/suppositories - Respiratory insufficiency or depression severe CNS depression attack of bronchial asthma heart failure secondary to chronic lung disease cardiac arrhythmias increased intracranial or CSF pressure head injuries brain tumor acute alcoholism delirium tremens convulsive disorders after biliary tract surgery suspected surgical abdomen surgical anastomosis concomitantly with MAOIs or within 14 days of such treatment paralytic ileus. 

Contraindications Hypersensitivity to morphine sulfate or any component of the formulation, increased intracranial pressure, severe respiratory depression, severe hepatic or renal insufficiency, pregnancy (prolonged use or high dosages near term)... 

A second arbitrary group was established for animals that died 6-24 h after exposure. Tracheobronchitis and bronchopneumonia appeared to be the causes of death, except that in half the rats and two-thirds of the guinea pigs the lesions were insufficient to explain their deaths. After 24 h, nearly all the animals that eventually died had severe respiratory lesions. In the absence of controls, the Investigators were reluctant to say that CA caused the lesions found in survivors. 

Malfunctioning of the respiratory centre (raised intracranial pressure, severe pulmonary insufficiency) causes patients to be intolerant of opioids, and indeed any sedative may precipitate respiratory failure. 

Attention must be paid to severe clotting disorders, cardiac and coronary insufficiency, severe cardiac arrhythmia, serious hypertension, respiratory insufficiency and purulent peritonitis as possible contraindications. The same is true of Bekhterev s disease and cerebral insufficiency (depending on the respective severity). Despite a wide range of indications, the list of contraindications (with the exception of hepatogenic clotting disorders) only covers severe extrahepatic diseases. In these cases, it is the treatment of the serious condition which is of paramount importance and not the diagnostic clarification of abdominal or hepatobiliary diseases. (228, 244, 254, 266, 275) (s. tab. 7.13)... 

Classic signs of acute toxicity include pinpoint pupils, muscular fasciculations, slow pulse, excessive salivation and lacrimation, and gastrointestinal symptoms (nausea, abdominal cramps, diarrhea, and loss of sphincter control). In severe cases, convulsions, coma, and heart block are common. Death is generally attributed to respiratory insufficiency caused by the combination of respiratory center depression, paralysis, and increased bronchial secretions. In children, the classic signs described previously may be infrequent, with the major symptoms being central nervous system depression, stupor, flaccidity, dyspnea, seizures, and coma. 

Contraindications. Contraindications include hypersensitivity to opioids, head trauma or increased intracranial pressure, severe respiratory depression or compromised respiratory function, and potentially, liver or renal insufficiency (46). Whether morphine or other opioids are used depends on the severity of the contraindication, and the potential benefits must be weighed relative to the risk. Anaphylactoid reactions have been reported after morphine or codeine administered i.v., although the reactions are rare (23). Morphine... 

Metabolites in human blood are closely associated with the state of an individual s health. Determination of metabolites is critical in clinical diagnosis, since they can serve as a criterion for judging the severity of the sickness. Of these metabolites, glucose, lactate and urea are most frequently determined. Special attention to determination of glucose in blood is due to the fact that diabetes is well known as a dangerous and widespread disease that results in a high glucose concentration in the blood. Some other effects of metabolites, such as urea and lactate, on shock, respiratory insufficiency, and heart and kidney diseases are understood to some extent. 

Pulmonary-toxic - different degrees of disturbances in the ventilation processes of the respiratory system are observed, including dispnea, painful coughing, pains behind the chest bone, severe cyanosis, acute respiratory insufficiency the degree of severity of the affection depending on the severity of the poisoning ... 

Clinical picture. The first stage is characterized by catarrhal syndrome in the eye and the respiratory tract mucosa. A few hours later phenomena are manifested including severe pul-monary toxic oedema with acute respiratory insufficiency and blood circulation disorders caused very often by pulmonary arterial... 

Pulmotoxic syndrome severe lung oedema, acute respiratory insufficiency, bron-chopneumonia. 

The objective status General status - very severe, shock state, dispnoea, severe lung oedema, cyanoses, heavy respiratory insufficiency. After treatment with reanimation preparations, pulmo-protective therapy and detoxic drugs, the patient recovered. 

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