Clotting disorders

Kogenate (rhFactor VIII) Helixate NexGen (rhFactor VIII) NovoSeven (rhFactor Vila) Recombinate (rhFactor VIII) ReFacto (B-domain deleted rhFactor VIII) 

Baxter Healthcare/Genetics Institute Genetics Institute 

Haemophilia A Haemophilia A Haemophilia B Haemophilia A Haemophilia A Some forms of haemophilia Haemophilia A Haemophilia A 

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In a patient presenting with a bleeding or clotting disorder, an initial evaluation should include bleeding time, prothrombin time (PT), activated partial thromboplastin time (aPTT), thrombin time, and platelet count. 

Cause Most common is cerebrovascular occlusion. Other causes include intracranial hemorrhage, cardiac embolisms, infection, and clotting disorders. 

Drugs used in clotting disorders Clot reducers Anticoagulants Antiplatelet agents Thrombolytics Clot facilitators... 

The human requirement for vitamin K appears to be very small but mild clotting disorders may result from digestive disturbances with consequent insufficient absorption of vitamin K. 

Some side effects, or adverse effects, of drugs can be fatal. Adverse drug reactions are one of the top 10 causes of death in hospitalized patients in the United States—as many as 100,000 deaths per year Even aspirin at low doses, recommended to prevent heart attacks and stroke, can kill under the right conditions Fatal bleeding can occur in patients who have an undetected clotting disorder and take aspirin r ularly. 

F. Place in therapy Micromedex notes that the major use of factor IX is in the therapy of hemophilia B, but it may also be useful in patients with clotting disorders secondary to hepatic dysfunction and other conditions. Recombinant factor IX BeneFix), however, is used specifically for the prevention and control of bleeding in patients with hemophilia B. 

Steroids that aid in muscle development are called anabolic steroids. They are synthetic derivatives of testosterone, thus have the same muscle-building effect as testosterone. There are more than 100 different anabolic steroids which, vary in structure, duration of action, relative effects and toxicities. Androstenedione, stanozolol and dianabol are anabolic steroids. They are used to treat people suffering from traumas accompanied by muscle deterioration. The use of anabolic steroid can lead to a number of dangerous side-effects, including lowered levels of high density lipoprotein cholesterol, which benefits the heart, and elevated levels of harmful low density lipoprotein, stimulation of prostate tumours, clotting disorders and liver problems. 

Q4 Excessive bleeding during the menstrual period is called menorrhagia. The blood loss reduces levels of iron in the body and may result in iron-deficiency anaemia. The causes of excessive bleeding could be inflammation, fibroids, endometriosis, cervical polyps, adenomyosis, ovarian tumours, intrauterine devices (IUDs), inherited clotting disorders, endocrine dysfunction, such as thyroid dysfunction, or mental stress. In terms of drug therapy, oral ferrous... 

Compound 165 and its derivatives inhibit serine protease enzymes such as TF/factor Vila and Xa (tissue factor) <2004USP0235852>. Benzofurans 166 and 167, which have transposed functional groups, are both TF/factor X inhibitors. Tissue factors are involved in the release of thrombin, so these compounds are applied to the treatment of clotting disorders <2003W003082847, 2005JPP2005120080>. Diarylbenzofuran 168 is used to inhibit bone loss <1996USP5489587>. 

Attention must be paid to severe clotting disorders, cardiac and coronary insufficiency, severe cardiac arrhythmia, serious hypertension, respiratory insufficiency and purulent peritonitis as possible contraindications. The same is true of Bekhterev s disease and cerebral insufficiency (depending on the respective severity). Despite a wide range of indications, the list of contraindications (with the exception of hepatogenic clotting disorders) only covers severe extrahepatic diseases. In these cases, it is the treatment of the serious condition which is of paramount importance and not the diagnostic clarification of abdominal or hepatobiliary diseases. (228, 244, 254, 266, 275) (s. tab. 7.13)... 

Contraindications Contraindications include clotting disorders, echinococcus cyst, marked ascitis, liver abscess, liver metastases and cirrhosis. 

Complications Complications include clotting disorders (22, 183, 185) and the bacterial infection of ascites. 

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