Serum progesterone level

Sierra EM, Tiffany-Castiglioni E. 1992. Effects of low-level lead exposure on hypothalamic hormones and serum progesterone levels in pregnant guinea pigs. Toxicology 72 89-97. 

Serum progesterone Descriptive statistics and comparison of serum progesterone concentrations in cycles 1 and 2. Descriptive comparison of the proportion of subjects who ovulated whilst receiving Drug XYZ and contraceptive concomitantly and the proportion of subjects who ovulated whilst receiving contraceptive alone. Ovulation was assumed if serum progesterone levels exceeded 1.4 ng/mL on day 20 of a menstrual cycle. Individual and mean/median profiles were presented graphically. 

Most but not all studies point toward the general conclusion that elevated serum progesterone levels on the day of hCG administration reflect a good ovarian response (higher estradiol levels, more oocytes) but has a bad effect on the endometrial receptivity (lower ongoing pregnancy rate) (H7). Serum progesterone level in the late follicular phase is not fit to be used as an indicator for treatment outcome in assisted reproduction. 

G4. Givens, C. R., Schriock, E. D., Dandekar, P. V., and Martin, M. C., Elevated serum progesterone levels on the day of human chorionic gonadotropin administration do not predict outcome in assisted reproduction cycles. Fertil. Steril. 62, 1011-1017 (1994). 

Silverberg, K., Burns, W., Olive, D., Riehl, R., and Schenken, R., Serum progesterone levels predict success of in vitro fertilization/embryo transfer in patients stimulated with leupro-lide acetate and human menopausal gonadotropins. J. Clin. Endocrinol. Metab. 73, 797—803 (1990). 

In rats orally administered 250 or 500 mg/kg of an aqueous extract of jasmine daily, a dose-dependent anti-implantation effect was observed, although neither dose produced complete infertility. A decrease in serum progesterone levels was observed on day 5 of pregnancy. No abortifacient activity was observed in rats administered the extract on days 8 to 20 of pregnancy, and no abnormalities were observed in offspring (Iqbal et al. 1993). 

Hess et al., 1983) were correlated with a daily regime of "sniff tests during which a bull was allowed limited access to each cow for several minutes flehmen responses and checks were recorded. The data obtained established an inverse correlation of serum progesterone levels with the male flehmen response (Hess et al., 1983). 

Disorders affecting ovulation account for 30%-40% of cases of female infertility [1]. Measures of ovarian function include measurement of basal body temperature, endometrial biopsy, measurement of serum progesterone level, endocrine tests, and monitoring of follicle growth with US. Thus the role of MR imaging is limited to assessment of whether a pituitary adenoma is present [20]. 

An aqueous extract of fresh coriander seeds produced a dose-dependent significant antiimplantation effect in rats (related to a significant decrease in serum progesterone levels after 5 days). ... 

E. Therapeutic response Follicle maturation during follitropin beta therapy is best monitored by daily ultrasonography and daily measurement of serum and/or urine estradiol levels. Ovulation may be clinically confirmed by an increase in serum progesterone as well as an elevation in basal body temperature. 

Secondary The secondary objective of the study was (i) to assess whether Drug XYZ affects the contraceptive effect of the oral contraceptives containing ethinylestradiol as reflected by changes in serum progesterone and 17- 3-estradiol levels, and (ii) to evaluate the safety, tolerability and pharmacokinetics of repeated once-daily oral doses of Drug XYZ. 

Pharmacodynamics Serum progesterone and 17-P-estradiol levels are considered reliable indicators for the occurrence of ovulation. Since progesterone and 17-f)-cstradiol levels were comparable for both treatments, and progesterone serum concentrations did not exceed 1.4 ng/mL (as defined in this study, progesterone concentrations above 1.4 ng/mL on day 20 of a menstrual cycle indicated ovulation) for both treatments, it was concluded that Drug XYZ administration did not affect the contraceptive effect of ethinylestradiol-based oral contraceptives and that no ovulation occurred in any of the subjects. 

Paired serum progesterone measurements, however, one 12 h before and the other 12 h after hCG administration, can predict the chance of success of the cycle. A threefold or more increase in progesterone levels after hCG administration correlates significantly with implantation and ongoing pregnancy rates (P9). 

Exposure of two species of freshwater fish to 0.106 ppb of a commercial formulation containing 50% methyl parathion increased serum levels of T3 and reduced T4 (Bhattacharya 1993). This effect was attributed to inhibition of acetylcholinesterase activity in the fish brain, but no direct evidence was presented. Similar treatment of freshwater perch for 35 days resulted in decreased release of progesterone from the ovaries (Bhattacharya and Mondal 1997). Also, treatment of freshwater perch for up to 90 days with methyl parathion induced a decrease in the gonadosomatic index (not defined) after day 15 of... 

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