Serum biochemistry

Wise, L.D., Clark, R.L., Minsker, D.H. and Robertson, R.T. (1988). Use of hematology and serum biochemistry data in developmental toxicity studies. Teratology 37 502-503. 

Parsons, A. and Wells, R. (1986). Serum biochemistry of healthy Yucatan miniature pigs. Lab. Animal Sci. 36 428 130. 

Shore, V., and Shore, B., Some physical and chemical studies in two polypeptide components of high density lipoproteins of human serum. Biochemistry 7, 3396-3404 (1968). 

Several studies have failed to confirm the benefits of combined levothyroxine and liothyroninc therapy. Liothyroninc given once a day results in non-physiologi-cal peak serum concentrations of T3. Modified-release triiodothyronine plus thyroxine can normalize serum biochemistry, but it is not known whether this formulation is superior to levothyroxine alone (15). 

Serum biochemistry methods were used to evaluate the toxic effect of the procedure. The parameters evaluated include concentrations of major ions (Na+,K+,C1 ) major proteins (albumin and total protein) liver-specific enzymes (alkaline phosphatase ALP) aspartate aminotransferase (AST), alanine aminotransferase (ALT)... 

Table 21.3 Effect of hydrodynamics-based procedure on serum biochemistry...

Yang, J.-L. and Chen, H.-C. (2003) Effects of gallium on common carp (Cyprinus carpio) acute test, serum biochemistry, and erythrocyte morphology, Chemosphere 53 (8), 877-882. 

G35. Gustafson, A., Alaupovic, P., and Furman, R. H., Studies of the composition and structure of serum lipoproteins. Separation and characterization of phospholipid-protein residues obtained by partial delipidization of very low density lipoproteins of human serum. Biochemistry 5, 632-640 (1966). 

Autoimmune hepatitis typically occurs in females, at puberty and between the ages of 40 and 70. It can also occur in males at any age. It may present in a number of ways as a mild hepatitis, as a severe acute hepatitis or as established cirrhosis. The functioning capacity of the liver will vary depending on the stage of disease. The diagnosis of AIH is based on serum biochemistry, liver histology, and the presence of certain autoantibodies in the serum. Exclusion of other potential causes of hepatitis, e.g. hepatitis B or C, alcohol consumption, is needed before a definitive diagnosis can be made. There are no featnres that are specifically indicative of AIH, but it usually responds to treatment with corticosteroids. Once remission is indnced azathioprine or... 

Pang, V.F., Felsburg, P.J., Beasley, V.R., Buck, W.B., Haschek, W.M. (1987a). The toxicity of T-2 toxin in swine following topical application. II. Effects on hematology, serum biochemistry, and immune response. Fundam. Appl. Toxicol. 9 50-9. 

The effect of oral pancreatic enzyme supplementation (Creon 10 000 in a dose of 1000 units of lipase per gram of ingested dietary fat) on fat malabsorption has been evaluated in an open study in 24 patients with HIV infection (1). Pancreatic enzyme supplementation was highly effective in reducing fecal fat loss. There were no clinical adverse effects or changes in serum biochemistry attributable to the drug. 

The safety of perflenapent has been evaluated in multicenter phase II studies in 146 patients with congestive heart failure (NYHA class III or IV, mean age 68 years), of whom 99 received perflenapent and 47 received isotonic saline, and in 134 patients with severe chronic obstructive pulmonary disease (FEVi no more than 60% of predicted, mean age 65 years), of whom 91 received perflenapent and 43 received isotonic saline (13). Blood pressure, heart rate, respiratory rate, oxygen saturation, the electrocardiogram, FEVi, complete serum biochemistry, hematology, and mental state were assessed. Adverse events were mild and required no treatment. There was no significant difference in the incidence of adverse reactions between those given perflenapent (15%) and those given placebo (11%). The most frequent adverse events with perflenapent were vasodilatation (n = 8), taste disturbance (n = 6), nausea (n = 5), and headache (n = 3). 

Examination of the urine revealed macroscopic blood and granular casts. Her serum biochemistry was abnormal with hyperkalemia and an elevated urea and creatinine. She ultimately required dialysis but recovered sufficient renal function within 3 days to allow cessation of dialysis therapy. In view of the close association between the exposure to the Jeyes... 

In one study, a group of people who were exposed to a mixture of toluene (2.73) and mixed xylenes (3.15) was compared to a control group that was exposed to the individual solvents alone. Additive effects were noted when exposures were to the mixture versus the individual solvents. Hematology and serum biochemistry did not show any notable changes from exposure to single chemicals versus the mixture. 41 ... 

L20. Lee, J. C., and Harpst, J. A., Physical properties and subunit structure of butyrylcholinesterase from horse serum. Biochemistry 12, 1622-1630 (1973). 

MH is a 40-year-old female with chronic renal failure who is being treated by haemodialysis. Her serum biochemistry just prior to her last dialysis showed ... 

Nomoto S, MgNeely MD and Sundeeman FW Jh. (1971) Isolation of a nickel a 2-macroglobulin from rabbit serum. Biochemistry 10 1647-1651. Novokhatskii NK, Sosnin W, Batianov IS and Danilenko LS (1987) The late sequelae of acute nickel tetracarbonyl poisoning. Gig Truda Prof Zabol 5 45-47. 

Kim, I. G., and S. Y. Park. 1997. Development of a competitive enzyme linked immunosorbent assay to measure a-2-macroglobuhn in irradiated rat serum. Biochemistry and Molecular Biology International 43 695-703. 

In mice orally administered different fractions of Phyllanthus amara at doses of 400, 800, or 1600 mg/kg daily for 14 days, changes in serum biochemistry were observed. Changes included elevations in aspartate aminotransferase (AST) and alkaline phosphatase (ALP), with differing effects on protein, total bilirubin, creatinine, and other liver enzyme levels. The changes were generally not dose-dependent (Adedapo et al. 2005). 

Adedapo, A. A., M.O. Abatan, S.O. Idowu, and 0.0. Olomnsogo. 2005. Toxic effects of chromatographic fractions of Phyllanthus amarus on the serum biochemistry of rats. Phytother. Res. 19(9) 812-815. 

Silva, 1. Kuruwita, V.Y. 1993. Hematology, plasma and serum biochemistry values in free-ranging elephants Elephas maximus Ceylonicus) in Sri Lanka. J. Zoo Wildl. Med., 24, 434-439. 

Parisi, A. F., and Vallee, B. L., 1970, Isolation of a zinc a2 rn croglobulin from human serum. Biochemistry 9 2421. 

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