Serum angiotensin-converting enzyme

Aviram, M. and Domfeld, L., Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure, Atherosclerosis, 158, 195-198, 2001. 

Tillman L G, Moore J N 1989 Serum angiotensin converting enzyme activity and response to angiotensin I in horses. Equine Veterinary Journal Supplement 7 80-83... 

Hosseini M, Shafiee SM, Baluchnejadmojarad T (2007) Garlic extract reduces serum angiotensin converting enzyme (ACE) activity in nondiabetic and streptozotocin-diabetic rats. Pathophysiology 14(2) 109-112. doi 10.1016/j.pathophys.2007.07.002... 

Serum angiotensin-converting enzyme (SACE) is increased in 30% to 80% of patients with sarcoidosis, and may be a surrogate marker of total granuloma burden (6,28). False positives are noted in fewer than 20% of patients with other pulmonary disorders. Importantly, SACE may be normal in patients with active disease (28). SACE provides ancillary information when the activity of sarcoidosis is uncertain on clinical grounds, but SACE should not be used in isolation to dictate therapeutic interventions. 

Newman LS, Orton R, Kreiss K. Serum angiotensin converting enzyme activity in chronic beryllium disease. Am Rev Respir Dis 1992 146(l) 39-42. 

Lecours R, Laviolette M, Cormier Y (1986) Bronchoalveolar lavage in pulmonary mycotoxicosis (organic dust toxic syndrome). Thorax 41(12) 924-926 Lee K et al. (2004) Personal exposures to inorganic and organic dust in manual harvest of California citrus and table grapes.) Occup Environ Hyg 1(8) 505-514 Lieberman J (1975) Elevation of serum angiotensin-converting-enzyme (ACE) level in sarcoidosis. Am J Med 59(3) 365-372... 

May JJ et al. (1990) Organic dust toxic syndrome a follow-up study. Am J Ind Med 17(1) 111-113 McCormick JR et al. (1981) Serum angiotensin-converting enzyme levels in patients with pigeon-breeder s disease. Chest 80(4) 431-433... 

ACE, angiotensin-converting enzyme aPTT, activated partial thromboplastin time ARB, angiotensin receptor blocker BP, blood pressure CBC, complete blood count ECC, electrocardiogram HR, heart rate INR, International Normalized Ratio RR, respiratory rate SCr, serum creatinine, TTP, thrombotic thrombocytopenic purpura. 

ACE-I, angiotensin-converting enzyme inhibitors ARB, angiotensin-receptor blockers AZA, azathioprine CMV, cytomegalovirus CPK, creatinine phos-phokinase CSA, cyclosporine HMG-CoA, 3-hydroxy 3-methylglutaryl coenzyme A reductase K+, potassium LFTs, liver function tests Rl, renal insufficiency SCr, serum creatinine SRL, sirolimus TAC, tacrolimus TMP-SMX, trimethoprim-sulfamethoxazole. 

As angiotensin-converting enzyme inhibitors influence protein excretion in renal disease, Gansevoort et al. (G2) and Keilani et al. (K10) investigated serum Lp(a) concentrations in patients treated with Lisinopril resp. fosinopril and detected a reduction. 

Because indomethacin may increase serum potassium concentrations, indomethacin and spironolactone should be administered concomitantly with caution. Potassium-sparing diuretics should be used with caution, and serum potassium should be determined frequently in patients receiving an angiotensin-converting enzyme (ACE) inhibitor (e.g., captopril). Concomitant administration with an ACE inhibitor may increase the risk of hyperkalemia. The dosage of spironolactone should be reduced, or the drug discontinued, as necessary. Patients with renal impairment may be at increased risk of hyperkalemia [65]. 

Angiotensin-converting enzymes (ACEs) Eukaryotes ACEs are involved in blood chemistry. They mostly exist at the cell surface as ectoenzymes, where they hydrolyze circulating peptides. Gene-targeting studies in mice have established that the tissue-bound form of ACE controls both blood pressure and renal stmcture and function, although a soluble form of ACE, which is derived from the membrane form through the action of a secretase, is also present in serum and other body fluids. Nonspecific endopeptidase 59, 60... 

Montanaro D, Gropuzzo M, Tulissi P, Boscutti G, Risaliti A, Baccarani U, Mioni G. Angiotensin-converting enzyme inhibitors reduce hemoglobin concentrations, hematocrit, and serum erythropoietin levels in renal transplant recipients without posttransplant erythrocytosis. Transplant Proc 2001 33(l-2) 2038-40. 

Borgia MC, Celestini A, Caravella P, Catalano C. Angiotensin-converting-enzyme inhibitor administration must be monitored for serum amylase and lipase in order to prevent an acute pancreatitis a case report. Angiology 2001 52(9) 645-7. 

---