Hemoglobin, reduced

Carbon monoxide Binds to hemoglobin, reducing oxygen delivery to tissues Headache, dizziness, nausea, vomiting, seizures, coma... 

Anemia A deficiency of red blood cells or hemoglobin, reducing the blood s capacity to carry oxygen. 

There is no cure for sickle cell disease and current therapies are aimed at managing the nnmerons complications associated with the condition. These therapies inclnde penicillin treatment, iimnunization against Streptococcus pneumoniae, blood transfusions, and hydroxyurea (12,20). Hydroxyurea is the only drug therapy specific for sickle cell disease. Hydroxyurea appears to act through several mechanisms, including increased production of fetal hemoglobin, reduced adhesion of blood cells to endothelial cells, improved erythrocyte hydration, and reduced neutrophil counts (21). Hydroxyurea has proven effective but there are some concerns with toxicity and not all patients respond to the treatment (21-23). There is clearly a need for development of additional therapies. 

Clinical manifestation. It includes several syndromes a) pulmotoxic and irritative syndrome - expressed by catarrhal changes on the contact mucosa and respiratory tract, toxic pulmonary oedema b) hemotoxic syndrome - expressed by severe hemolysis of different degrees, in the severe forms - hemolytic shock and anaemia c) hepatal syndrome - characterised by subicterus or icterus, increased liver and bilirubinaemia d) renal syndrome - by oliguria or anuria, pathological deviations in the urine and acute kidney insufficiency. In the extremely severe forms consciousness is disordered. Laboratory blood and urine chemical tests show evidence of phenol metabolites, data for blood damage (increased values of free hemoglobin, reduced number of erythrocytes), positive liver tests etc. 

Ferrohemoglobin, hemoglobin (reduced hemoglobin) a conjugated protein formed by combination of ferroheme and native protein. 

Hospitalized or screened children 40 [ig/dl PbB Hematological effects Anemia, reduced hemoglobin, reduced erythrocyte survival via hemolysis Chisolm and Barltrop (1979), Waldron (1966), NAV NRC(1972, 1980), USCDC (1978)... 

H. Methemoglobin + Ascorbic acid Hemoglobin (reduced) + Dehydroascorbic acid... 

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