Serological Findings

Passive transfer tests with the sera of six sensitive refinery workers were made with unheated serum for IgE, long-term sensitising antibody and with heated serum for short-term sensitising, presumably IgG antibody to prick tests (Pepys et al. 1979). Table 5 shows positive reactions with all of the unheated sera in one or more of the three human Prausnitz-Kiistner recipients and with two and probably three of the sera in Prausnitz-Kiistner tests in the monkey. These findings support the possibility of specific IgE antibodies to the platinum salts. 

In addition STS-IgG antibodies were shown by the reactions elicited by prick tests at sites passively sensitised with heated serum and tested within 2 h, in one of three human recipients and in the monkey. Thus the sensitised donors had both 

Prausnitz-Kustner human prick test 24-48 h (10 g/ml) wheal diameter (mm)  

Prausnitz-Kustner monkey intra-cutaneous test 24 h (50pg/10 g/ml) blue diameter (mm) 

RAST quotient (test serum versus cord blood) 

---

Tab. 5.17 Constellations of serological findings and their clinical interpretation during the course of HBV and HDV infection or HBV vaccination ( = immune complex) (107, 114-116, 119) (s. tab. 5.18)...

Carcinoid tumors, also called well-differentiated neuroendocrine tumor by the WHO 2004, are relatively uncommon in the EHBT. " They have the typical morphologic characteristics of carcinoids elsewhere (<10 mitosis per 10 high power field and minimal, or no, necrosis) and are commonly but not always positive for chromogranin (Fig. 15.23), synaptophysin, and CD56. Hormones commonly detected at the immunohistochem-ical level are serotonin and somatostatin, although these do not necessarily correlate with serologic findings. ... 

Dominant structure in IgE-binding determinant (in bold font) Serological findings Clinical relevance... 

Burdt MA, Hoffman RW, Deutscher SL, et al. Long-term outcome in mixed connective tissue disease longitudinal clinical and serologic findings. Arthritis Rheum 1999 42 899-909. 

Diagnosis Clinical diagnosis. Physical findings are usually non-specific. Chest X-ray may reveal a pneumonic process, mediastinal lymphadenopathy or plural effusion. Routine culture is possible but difficult. The diagnosis can be established retrospectively by serology. As for treatment, administration of antibiotics such as streptomycin or gentamicin with early treatment can be very effective. 

Serology Guttormsen et al. 136 CD subjects Serum samples were Gliadin, avenin, and tTG Findings support the... 

A 65-year-old woman developed fatigue, jaundice, and altered liver function tests while taking atorvastatin (20 mg/day for some weeks) (14). On the basis of clinical, serological, and histological findings, a diagnosis of autoimmune hepatitis was made. 

Rheumatoid arthritis has been reported to be associated with RLS in up to 25 % of cases [43], but serological analysis of 68 RLS patients failed to find association with rheumatological serologies [44], The same holds true for diabetes, often reported in association with RLS however, a recent extensive clinical study did not find a significantly higher prevalence of RLS in diabetic patients [44], Neuropathies associated with rheumatoid arthritis and diabetes may be the cause of RLS in these patients. In patients with end-stage kidney disease, reports showed a mild or overt (from moderate to severe) RLS in up to 62 % of cases [45,46], No correlation with iron levels or other uremia characteristics such as a decrease in parathormone levels has been found [46], Parkinson s disease (PD) has frequently been associated with... 

Healthy male subjects, aged 18-45 years (inclusive), with a Body Mass Index between 18 and 27 kg/m2 (inclusive), normal or clinically irrelevant abnormal findings (in the opinion of the investigator) in the medical history and physical examination, laboratory values, ECG, blood pressure and pulse rate, negative serology (HIV antibody, hepatitis B surface antigen, hepatitis C antibody) and urine screen for drugs of abuse. 

Skelly, M.M., James, P.D., Ryder, S.D. Findings on liver biopsy to investigate abnormal liver function tests in the abscence of diagnostic serology. J. Hepatol. 2001 35 195-199... 

---