Selected ion flow tube mass spectrometry

Smith D, Spanel P (2005) Selected ion flow tube mass spectrometry (SIFT-MS) for on-line trace gas analysis. Mass Spectrom Rev 24(5) 661-700... 

However, the desire to reduce or even eliminate the required sample preparation has led to the development of newer techniques, such as proton-transfer-reaction mass spectrometry (PTR-MS) and selected ion flow tube mass spectrometry coupled with ion mobility spectrometry (MS-SIFT IMS). These techniques allow real-time measurements within a single second. This enables analysis of gas composition during technological processes, monitoring of indoor air, and investigation of VOCs emitted by living organisms. 

Selected ion flow tube mass spectrometry (SIFT-MS) is an analytical technique used for direct and quantitative determination of VOCs in mixtures of gases. SIFT-MS was introduced in 1976 by N. G. Adams and D. Smith. The technique can be applied for parallel real-time monitoring of a few substances [126]. A scheme of the SIFT-MS system is presented in Fig. 14.9 [127]. The principle of gas mixture analysis is based on the reaction of reagent ions with molecules of analyte within a specific time (a few milliseconds). In this method, chemical ionization is applied reagent ions are generated in the ion source by a suitable ionization gas (nitrogen, oxygen, or water vapor). Of aU the obtained ions, only cations of the desired m/z... 

Fig. 14.10 Mass spectrum of volatile organic compounds in expired air, obtained using selected ion flow tube mass spectrometry. H30 ions were applied as reagent ions [127]...

Spanel, P., Diskin, A.M., Abbott, S.M., Wang, T., Smith, D. Quantification of volatile compounds in the headspace of aqueous liquids using selected ion flow tube mass spectrometry. Rapid Commun. Mass Spectrom. 16, 2148-2153 (2002)... 

Smith, D., Spanel, P. Selected ion flow tube mass spectrometry, SIFT-MS, for on-line trace gas analysis. In Amann, A., Smith, D. (eds.) Breath Analysis for Clinical Diagnosis and Therapeutic Monitoring, pp. 3-34. World Scientific Publishing, Toh Tuck Link, Singapore (2005)... 

A more sophisticated, though less common version of PTR-MS is selected ion flow tube mass spectrometry (SIFT-MS). In this technique, a mixture of reagent ions is generated in a gas discharge ion source and then a Q mass filter is used to select one reagent ion, which is then injected into an inert carrier gas (usually He), for... 

SIFT-MS selected ion flow tube mass spectrometry... 

This volume contains excellent discussions of the various methods for studying ion-molecule reactions in the gas phase, including high pressure mass spectrometry, ion cyclotron resonance spectroscopy (and FT-ICR) and selected ion flow tube mass spectrometry. 

Freeman CG and McEwan MJ (2002) Rapid analysis of trace gases in complex mixtures using selected ion flow tube-mass spectrometry. Australian Journal of Chemistry 55 491 94. 

Milligan, D.B., Wilson, P.F., Mautner, M.N., Freeman, C.G., McEwan, M.J., Clough, T.J., Sherlock, R.R. (2002) Real-time, High-resolution Quantitative Measurement of Multiple Soil Gas Emissions Selected Ion Flow Tube Mass Spectrometry. J. Environ. Qual. 31 515-524. 

Hastie, D.R., Gray, J., Langford, V.S.,Maclagan,R.G.A.R.,Milligan,D.B.,McEwan, M.J. (2010) Real-time Measurement of Peroxyacetyl Nitrate Using Selected Ion Flow Tube Mass Spectrometry. Rapid Commun. Mass Spectrom. 24 343-348. 

Pena Quevedo has reported the detection of TATP using direct analysis in real time (DART). The method utilizes an atmospheric pressure ionization source coupled to a TOFMS to observe ammonium adducts of TATP [55]. Wilson et al. have reported the real-time detection of TATP using selected-ion flow tube mass spectrometry [56]. 

Wilson, PT., Prince, B.J., McEwan, M.J. (2006) Application of selected-ion flow tube mass spectrometry to the realtime detection of triacetone triperoxide. Anal. Chem., 78, 575-579. 

Those are, for instance, known as active chemical ionization mass spectrometry (ACIMS) for atmospheric trace-gas measurements in the chemosphere, proton transfer reaction mass spectrometry (PRT-MS), selected ion flow tube mass spectrometry (SIFT-MS), ion-molectrle reaction mass spectrometry (IMR-MS), ion attachment mass spectrometry (lAMS), and ion mobility spectroscopy (IMS). Those have now become part of the exterrsive resources of experimental techniques dedicated to all the scientific fields, especially such as fundamentals of gas-phase ion kinetics and thermochentistry, physical organic chemistry, atmospheric chemistry, interstellar chemistry, plasma, and combustion chemistry, radiation chemistry, analytical chemistry, and irltimately even medicine and biology. 

Fig. 4.7 Schematic diagram of a flowing afterglow mass spectrometry setup. The system is setup to perform reactions with H3O+. Other primary ions can be generated by other types of ion sources. (Adapted from ref [121] and Smith, D. panel, R Selected ion flow tube mass spectrometry (SlFT-MS) for online trace gas analysis. Mass Spectrom Rev. 24, 2005, 661-700] with permission of Wiley. 2001 and 2005, Wiley, Ltd.)...

Alkali metal ion/molecule association reactions have been exploited in various mass spectrometric methods since the early 1970s. Initial studies were to determine metal ion affinities of simple compounds, with use of Fourier transform ion cyclotron resonance (FTICR) mass spectrometers. Alkali ions offer unique and interesting potential in analytical chemistry and studies of chemical dynamics. Consequently, the use of metal ions as reagents for Cl mass spectrometry has been developed. The major advances in the apphcation of MS as a routine analytical instmment using the complex ion/molecule chemistry came arotmd in the past decades. They include atmospheric pressure chemical ionization (APCI), proton transfer reaction mass spectrometry (PTR-MS), selected ion flow tube mass spectrometry (SIFT-MS), ion attachment mass spectrometry (lAMS) and ion molecrtle reaction mass spectrometry (IMM-MS). 

Selected Ion Flow Tube-Mass Spectrometry (SIFT-MS)... 

Smith D, Spanel P, Dabill D, et al. On-line analysis of diesel engine exhaust gases by selected ion flow tube mass spectrometry. Rapid Commun Mass Spectrom. 2004 18 2830-8. 

Prince BJ, Milligan DB, McEwan MJ. Applications of selected ion flow tube-mass spectrometry to real-time atmospheric monitoring. Rapid Commun Mass Spectrom. 2010 24 1763-9. 

Sovova K, Shestiviska V, Spanel P. Real-time quantification of trace biogenic volatile selenium compounds in humid air by selected ion flow tube mass spectrometry. Anal Chem. 2011 84 4979-83. 

Spanel P, Smith D. Selected ion flow tube-mass spectrometry detection and real-time monitoring of flavours released from food products. Rapid Commun Mass Spectrom. 1999 13 585-96. 

Azcarate C, Barringer SA. Effect of enzyme activity and frozen storage on jalapeno pepper volatiles by selected ion flow tube-mass spectrometry. J Food Sci. 2010 75 C710-C21. 

Agila A, Barringer S. Application of selected ion flow tube mass spectrometry coupled with chemometrics to study the effect of location and botanical origin on volatile profile of unifloral American honeys. J Food Chem. 2012 77 C1103-C8. 

Olivares A, Dryahina K, Navarro J, et al. Selected ion flow tube-mass spectrometry for absolute quantification of aroma compounds in the headspace of dry fermented sausages. 

Noseda B, Ragaest P, Pauwels D, et al. Validation of selected ion flow tube mass spectrometry for fast quantification of volatile bases produced on Atlantic cod. J Agric Food Chem. 2010 58 5213-9. 

Taylor K, Wick C, Castada H, et al. Discrimination of Swiss cheese fiom 5 different factories by high impact volatile organic compound profiles determined by odor activity values using selected ion flow tube-mass spectrometry and odor threshold. J Food Sci. 2013 78 C1509 15. 

Castada HZ, Wick C, Taylor K, et al. Analysis of selected volatile organic compounds in split and non-split Swiss cheese samples using selected ion flow tube mass spectrometry (SIFT-MS). J Food Sci. 2014 79 C489-C98. 

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