Secretory immunoglobulin

Hammerschmidt, S., Talay, S. R., Brandtzaeg, P., and Chhatwal, G. S. (1997). SpsA, a novel pneumococcal surface protein with specific binding to secretory immunoglobulin A and secretory component. Mol. Microbiol. 25,1113-1124. 

Manjarrez-Hernandez, H. A., Gavilanes-Parra, S., Chavez-Berrocal, E., Navarro-Ocana, A., and Cravioto, A. (2000). Antigen detection in enteropathogenic Escherichia coli using secretory immunoglobulin A antibodies isolated from human breast milk. Infect. Immun. 68, 5030-5036. 

IgA a K or L 160 340 (dimer) Toxin-neutraUzing, agglutinating, opsonizing, secretory immunoglobulin Serum, secretions, colostrum, saliva, tears, GI tract... 

IgA is the primary secretory immunoglobulin and occurs in tears, nasal and intestinal secretions, saliva, and bile. Il is present as a 7S IgA, it is an I IS dimer with the monomeric structures joined by a J chain and linked to a glycoprotein called secretory component. Secretary IgA plays a role in initial protection against external pathogens, aggregates bacteria, and neutralizes viruses. 

Knight, K.L., Malek, T.R., Hanly, W.C. (1974). Recombinant rabbit secretory immunoglobulin molecules alpha chains with maternal (paternal) variable-region allotypes and paternal (maternal) constant-region allotypes. Proc. Natl. Acad. Sci. USA 71, 1169-1173. 

Quan, C. P., Bememan, A., Pires, R., Avrameas, S., and Bouvet, J.-P. 1997. Natural polyreactive secretory immunoglobulin A autoantibodies as a possible barrier to infection in humans. Infect. Immun. 65 3997-4004. 

Improve the defense barriers of the immune system by increasing production of secretory immunoglobulin class A (s-IgA)... 

The columnar epithelial cells of the intestinal mucosa actively absorb and secrete extracellular ions, nutrients, and water. The active secretion of ions by these cells with an accompanying fluid flux acts to dilute and purge microorganisms or toxins in the bowel promotes the transfer of secretory immunoglobulin A, antimicrobial defensin peptides, and mucin into intestinal mucus and the gut lumen and, by affecting intraluminal pH, may alter the growth characteristics of enteric microflora [121]. Mucosal secretion is modulated by several enteric neurotransmitters, as well as inflammatory mediators released by mucosal mast cells that may affect transport indirectly through their ability to stimulate enteric neurons [122],... 

Stephens, S., Dolby, J.M., Montreuil, J., and Spik, G. 1980. Differences in inhibition of the growth of commensal and enteropathogenic strains of Escherichia coli by lactotransferrin and secretory immunoglobulin A isolated from human milk. Immunology 41, 597-603. 

Tourville DR, Adler RH, Bienenstock J, Tomasi TB, Jr. The human secretory immunoglobulin system immunohistoligical localization of gamma A, secretory piece, and lactoferrin in normal human tissues. / Exp Med 1969 129(2) 411-29. 

Proctor GB, Carpenter GH. Chewing stimulates secretion of human salivary secretory immunoglobulin A. J Dent Res 2001 80(3) 909-13. 

Brandtzaeg P. Human secretory immunoglobulins. II. Salivary secretions from individuals with selectively excessive or defective synthesis of serum immunoglobulins. Clin Exp Immunol 1971 8(1) 69—85. 

Salivary agglutinin and mucin Secretory immunoglobulin (slgA)... 

Gut-associated lymphoid tissue (GALT) Secretory immunoglobulin A Hepatic Kupffer cells... 

Although the total B-cell population has been low due to the lymphopenia the 7oPBM s recognised as B cells remains normal, as have serum and secretory immunoglobulins. Immunoelectrophoresis has shown no monoclonal band. Sero-conversion to respiratory syncytial virus has been noted (litre 1/10,1/40,1/10 at 6,12, and 16 months respectively. The patient was immunised with diptheria and tetanus toxoid plus inactivated polio vaccine at 4,6 and 12 months. No polio antibodies were detected but following tetanus immunisation 1-2 units/ml tetanus antitoxin were produced. There has been no response to intradermal Candida antigen at 6,12, and 15 months of age. 

Human milk has multiple components that likely mediate this anti-infectious, immuno-logically enhancing effect. These include secretory immunoglobulin A, lactoferrin, lysozymes, intact cellular components, and oligosaccharides. A comprehensive list of compounds found in human milk by class of ingredient is shown in Table 3-2. 

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