Polio vaccine, inactivated

The parent of a child about to receive the intramuscular polio vaccine, inactivated poliovirus vaccine (IPV), asks the nurse Why can t my child get the oral vaccine like I took when I was a child Which statement by the nurse is the best explanation to give the client ... 

Inactivated polio vaccine (IPV). An all-IPV schedule is recommended for routine childhood polio vaccination in the United States. All children should... 

Polio is the only disease, at present, for which both hve and killed vaccines compete. Since the introduction of the killed vims (Salk) in 1956 and the live attenuated virus (Sabin) in 1962 there has been a remaikable decline in the incidence of poliomyelitis (Fig. 16.1). The inactivated polio vaccine (TPV) contains formalin-killed poliovirus of all three serotypes. On injection, the vaccine stimulates the production of antibodies of the IgM and IgG class which neutrahze the vims in the second stage of infection. A course of three injections at monthly intervals produces long-lasting immunity to all three poliovirus types. 

In the 1950s, Dr. Jonas Salk and Dr. Albert Sabin from the University of Pittsburgh (USA) worked on polio vaccines. Salk used inactivated polio virus, whereas Sabin developed a live form of polio virus. 

In 1955,10 children died after being given improperly inactivated polio vaccine. 

Poliomyelitis (polio) IPV (Inactivated poliovirus vaccine) OPV (Oral polio vaccine) Cell based... 

Polio virus vaccine Inactivated Subcutaneous Two doses, 4 to 8 weeks apart and a third... 

Another approach is the whole-killed or inactivated vaccine. These vaccines are derived from the pathogen itself, rather than a weakened form, as are live attenuated vaccines. Chemical (e.g., formalin, ether, and beta-propiolactone) or physical (e.g., heat, ultraviolet, and gamma irradiation) means, or combinations thereof, are used to inactivate the pathogen. Notable examples of this type of viral vaccine include the inactivated polio vaccine... 

Abbreviations. DTaP, diphtheria-tetanus-acellular pertusis vaccine Hep B, hepatitis B Hep A, hepatitis A IPV, inactivated polio vaccine Hib, Haemophilus influenzae type B. 

There are two types of pohomyelitis vaccines available. One is prepared from pohoviruses that as a rule have been inactivated by formaldehyde. Inactivated poliomyelitis vaccine (IPV) is given parenterally. The second group of polio vaccines comprises attenuated strains of live polioviruses (oral poliomyelitis vaccine, OPV), which are given orally these live vaccines are the most widely used. 

Various studies in both symptomatic and asymptomatic HIV-infected individuals have failed to show any special sensitivity to adverse effects after other immunizations, for example in children receiving live oral or inactivated polio vaccine, DPT or DT vaccine, or measles vaccine (98-101). 

Diphtheria and pertussis vaccines are seldom used as single-component vaccines but as components of diphtheria/tetanus vaccines and diphtheria/tetanus/pertussis vaccines. Combined diphtheria/tetanus/pertussis/Hib and diphtheria/tetanus/pertus-sis/Hep B vaccines with or without inactivated polio vaccine are available. 

The single-component viral vaccines are listed in Table 23.2 with notes similar to those provided with the bacterial vaccines. The only combined viral vaccine that is widely used is the measles, mumps and rubella vaccine (MMR Vac). In a sense however, both the inactivated (Salk) poliovaccine (Pol/Vac (inactivated)) and the live (Sabin) polio-vaccine (Pol/Vac (oral) are combined vaccines in that they are both mixtures of virus of each of the three serotypes of poliovirus. Influenza vaccines, too, are combined vaccines in that they usually contain components from several virus strains, usually from two strains of influenza A and one strain of influenza B. 

For children up to age 16 years with HTV infection, immunization following the standard schedules is recommended for hepatitis B, DTaP, pneumococcal conjugate vaccine (PCV7), H. influenzae type b (Hib), inactivated polio vaccine (IPV), and annual influenza. Two doses of MMR vaccine should be administered at least 1 month apart as soon as possible after the first birthday. MMR should be administered only to children who have no evidence or moderate evidence of immunosuppression. Two doses of varicella vaccine separated by... 

An inactivated trivalent vaccine developed by Jonas Salk was licensed for use in 1955. In 1987, an enhanced-potency inactivated poho vaccine (IPV) was introduced, and it has replaced the original inactivated vaccine. A live attenuated oral polio vaccine (OPV) was developed by Albert Sabin in 1962. OPV was the primary immunizing agent for poliovirus infection. Widespread OPV use is responsible for eradication of wild-type polio in most of the world. However, with no poliovirus circulation in the United States for years, IPV is the recommended vaccine for the primary series and booster dose for children. OPV will continue to be used in the areas of the world that have circulating pohovirus. The CEX7 maintains a stockpile of OPV to be used only in case of an outbreak. ... 

Hib Hemophilus influenzae type b HSCT hematopoietic stem cell transplant IMIG intramuscular immunoglobulin IPV inactivated polio vaccine ITP immune thrombocytopenic purpura IVIG intravenous immunoglobulin LAIV live attenuated influenza vaccine MMR measles-mumps-rubeUa vaccine OPV oral polio vaccine... 

Killed or inactivated vaccines contain dead cells of the bacteria or vims that causes the disease to be prevented. Examples include the Salk polio vaccine and the pertussis vaccine. 

DEVELOPMENT AND OPTIMIZATION OF A QUANTITATIVE WESTERN BLOT AND DOT BLOT PROCEDURE FOR THE DETERMINATION OF RESIDUAL HOST CELL PROTEINS PRESENT IN INACTIVATED POLIO VACCINE USING A GZU BASED SIGNAL REAGENT... 

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