Composite scaffolds

Scaffold Final scaffold composition and design Devices are held to the... 

Shelat, A.A. and Guy, R.K. 2007. Scaffold composition and biological relevance of screening libraries. Nat. Chem. Biol. 3, 442-446. 

If a scaffold is transplanted, the rate of biodegradability is important to ensure that the scaffold remains to support a transplant until a natural ECM replaces it. The biodegradation or resorption rate is a function of the scaffold composition, structure, and the mechanical load present at the site of transplantation. The necessary rate at which the scaffold is degraded varies according to the tissue type. For example, slow degradation is allowable in bone tissue, whereas in other tissues chronic inflammation may occur if the rate is too low.f It is important that the degradation by-products are nontoxic to the body. 

Rabbit AF cells were seeded into experimental groups. Biomechanical property, hydroxyproline produetion and DNA quantity of AF cells on each scaffold were measured. Cell-scaffold composites were implanted subcutaneously into athymic mice and then analyzed H E, Safranin-0 and type I collagen staining. This study showed the best disc cell proliferation capacity of FLGA/DBF(20%)... 

Several potential applications exist for MFCs in the near future, including roles as reduced or controlled permeability packaging materials and as tissue engineering scaffolds. Composite films based on LLDPE matrices have shown excellent improvements in oxygen barrier properties as well as improvements in mechanical properties. 

Control of cell fate by polyurethane scaffold composition... 

Rahman, M.M., Pervez, S., Nesa, B., Khan, M.A., 2012. Preparation and characterization of porous scaffold composite films by blending chitosan and gelatin solutions for skin tissue engineering. Polym. Int. 62, 79-86. 

A pristine chitosan/sUk fibroin nanofibrous membrane scaffold composite membrane scaffold w ith intrafibrillar nanohydroxyapatite w as prepared by in-situ blending of 10% or 30% nanohydroxyapatite before the electrospinning step. There was a deposition of nanohydroxyapatite through alternative soaking surface mineralization. 

Kempen DH, Lu L, Kim Ch et al (2006) Controlled drag release from a novel injectable biodegradable microsphere/scaffold composite based on poly(propylene fumarate). J Biomed Mater Res 77A 103-111... 

Ju YM, Yu BZ, West L, Moussy Y, Monssy FJ (2010) A dexamethasone-loaded PLGA microspheres/collagen scaffold composite Iot implantable glucose sensors. J Biomed Mater Res A 93A 200-210... 

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