Composites composite-based scaffolds

Briganti, E., Spiller, D., Mirtelli, C., KuU, S., Counoupas, C., Losi, P., Senesi, S., Di Stefano, R., Soldani, G., 2010. A composite fibrin-based scaffold for controlled delivery of bioactive pro-angiogenetic growth factors. Journal of Control Release 142,14—21. 

Lv, Q., Nair, L., Laurencin, C.T., 2009. Fabrication, characterization, and in vitro evaluation of poly(lactic acid glycolic acid)/nano-hydroxyapatite composite microsphere-based scaffolds for bone tissue engineering in rotating bioreactors. Journal of Biomedical Materials Research. Part A 91A (3), 679-691. Available at http //doi.wiley.eom/10.1002/jbm.a.32302. 

Why composite-based scaffolds for bone-tissue regeneration ... 

J. Kim, S. Bhattacharyya, P. Ducheyne, Bioactive ceramics and bioactive ceramic composite-based scaffolds, in P. Ducheyne (Ed.), Comprehensive Biomaterials, Tissue and Organ Engineering, vol. 5, Elsevier, 2011, pp. 255-267. 

Qi, R. Shen, M. Cao, X. Guo, R. Tian, X. Yu, J. Exploring the dark side of MTT viability assay of cells cultured onto electrospun PLGA-based composite nanofibrous scaffolding materials. Analyst 2011, 136 (14), 2897-2903. 

Several potential applications exist for MFCs in the near future, including roles as reduced or controlled permeability packaging materials and as tissue engineering scaffolds. Composite films based on LLDPE matrices have shown excellent improvements in oxygen barrier properties as well as improvements in mechanical properties. 

There is little difference between the ideal dental and bone tissue scaffolds. They must both be biomimetic to allow for cell interaction, provide sufficient structural support, degrade at a rate that is consistent with bone tissue formation, and able to incorporate various growth factors to aid in regeneration of native tissue. Supramolecular assembling peptide-based scaffolds provide a conduit for cell delivery due to its biomimetic namre. However, as a self-assembled scaffold, these peptide-based constructs often lack the structural capability to provide a stable dental scaffold by itself. To rectify this issue, it would be prudent to develop a composite scaffold capable of providing structural support while at the same time offering a biomimetic environment that degrades at a rate consistent with dental tissue formation. 

Guan J, Stankus J, Wagner W. Development of composite porous scaffolds based on collagen and biodegradable poly(ester urethanejurea. Cell Transpl 2006 15 S17-27. 

Trachtenberg JE, Mountziaris PM, Kasper FK, Mikos AG. Fiber-based composite tissue engineering scaffolds for drug delivery. Isr J Chem 2013 53 646-54. 

Kempen DH, Lu L, Kim Ch et al (2006) Controlled drag release from a novel injectable biodegradable microsphere/scaffold composite based on poly(propylene fumarate). J Biomed Mater Res 77A 103-111... 

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