Polyurethane scaffolds scaffold composition

In early experiments, degradable polyurethane scaffolds derived from lysine polyisocyanates and hexamethylene diisocyanate (HDI) were shown to support attachment, proliferation, and differentiation of osteoblasts. To enhance the modest osteoconduc-tivity of polyurethane scaffolds, recent studies have investigated addition of a ceramic component. Both polyurethane scaffolds and polyurethane/ceramic composites have been shown to support new bone formation in a number of preclinical studies. 

Cell growth When seeded on electrospun fibrous coUagen-blended or elastin/collagen-blended polyurethane scaffolds, the growth of smooth muscle cells (SMCs) increased by 283% and 224%, respectively. Wong et al. Composition... 

Control of cell fate by polyurethane scaffold composition... 

Guelcher SA, Gallagher KM, Srinivasan A, McBride SB, Didier JE, Doctor JS, et al. Synthesis, in vitro biocompatibUity and biodegradation, and mechanical properties of two-component polyurethane scaffolds effects of water and polyol composition. Tissue Eng 2007 13(9) 2321-33. 

His current activities include the application of polyurethane composites to the development of three-dimensional scaffold for cell growth (bacteria, plant and mammalian). 

In the case studies to follow, both hydrophilic and hydrophobic polyurethanes are used to affect remediation of polluted air and water. We will not discuss conventional wastewater systems because they represent large public works projects that dot the developed world. The first three case studies cover the use of reticulated foam as a scaffold for the remediation of polluted air. Another involves the use of a hydrophilic foam as a scaffold for a biofilter to treat aquaculture wastewater, permitting its return to the system (closing the recycle loop). Lastly, we will review our work on a composite of hydrophilic polyurethane grafted onto a reticulated foam to treat VOC-contaminated air. 

Our laboratory has used the composite technology described in Chapter 2 to produce a scaffold for the immobilization of enzymes. We used reticulated foams of various sizes and chemistries (polyethers or polyesters) and graft hydrophilic polyurethanes to their inside structures. 

Meng J et al (2009) Enhancement of nanofibrous scaffold of multiwalled carbon nanotubes/ polyurethane composite to the fibroblasts growth and biosynthesis. J Biomed Mater Res A 88 (1) 105-116... 

Li B, Yoshii T, Hafeman AE, Nyman JS, Wenke JC, Guelcher SA. The effects of rhBMP-2 released from biodegradable polyurethane/microsphere composite scaffolds on new bone formation in rat femora. Biomaterials 2009 30(35) 6768-6779. 

Adolph EJ, Hafeman AE, Davidson JM, Nanney LB, Guelcher SA. Injectable polyurethane composite scaffolds delay wonnd contraction and support cellular infiltration and remodeling in rat excisional wounds. J Biomed Mater Res A February 2012 100(2) 450-61. 

Zahedmanesh H, Stoddart M, Lezuo P, Forkmann C, Wimmmer MA, Ahni M, et al. Deciphering mechanical regulation of chondrogenesis in fibrin-polyurethane composite scaffolds enriched with human mesenchymal stem cells a dual computational and experimental approach. Tissue Eng Part A April 2014 20(7-8) 1197-212. 

---