Salmonella mutagenicity test carcinogens

Levin D-E, Hollstein M, Christman M-F, Schwiers E-A and Ames B-N (1982) A new Salmonella tester strain with A.T base pairs at the site of mutation detects oxidative mutagens. Proc Nad Acad Sci USA 79 7445-7449 Maron D-M, Ames B-N (1983) Revised methods for the Salmonella mutagenicity test. Mutation Res 113 173-215 McCann J, Springarn N-E, Kobory J and Ames B-N (1975) Detection of carcinogens as mutagens bacterial tester strains with R factor plasmids. Proc Nat Acad Sci USA 72 979-983... 

Ames B.N., McCann J. Yamasaki E. (1975) Methods for detecting carcinogens and mutagens with the Salmonella/mammalian microsome mutagenicity test. MutatRes, 31, 347-364. 

McCann, J. Ames, B. "The Salmonella/Microsome Mutagenicity Test Predictive Value for Animal Carcinogenicity " in "Origins of Human Cancer " Hiatt, H. H., Watson, J. D., Winsten, J. A., Eds., Cold Springs Harbor Laboratory Cold Springs Harbor, New York, 1977, pp. 1431-50. 

Ashby, J. and Tennant, R.W. (1988). Chemical structure, Salmonella mutagenicity and extent of carcinogenicity as indices of genotoxic carcinogens among 222 chemicals tested in rodents by the US NCI/NTP. Mutation Res. 204 17-115. 

McCann, J., Choi, E., Yamasaki, E., and Ames, B.N., Detection of carcinogens as mutagens in the Salmonella/ microsome test assay of 300 chemicals, Proc. Natl. Acad. Sci. USA, 72, 5135, 1975. 

Ames, B. N., McCann, J. and Yamasaki, E., Methods for Detecting Carcinogens and Mutagens with the Salmonella/Mammalian Microsome Mutagenicity Test , Mutat. Res. (1975) 31, 347. 

McCann, J. and Ames, B. N., The Salmonella/Microsome Mutagenicity Test Predictive Value for Animal Carcinogenicity, (p. 1431 in ref. 1)... 

Donahue, E. V., McCann, )., and Ames, B. N. Detection of Mutagenic Impurities in Carcinogens and Noncarcinogens by High-Pressure Liquid Chromatography and The Salmonella/Mlcrosome Test , Cancer Research (1978) 38, 431. 

In Chapter 1 Bruce N. Ames, the plenary speaker at the symposium, describes the development of the Salmonella/microsome assay, which is better known as the Ames Test. This test was the first proven rehable and rapid in-vitro method for the mutagenic and carcinogenic screening of chemicals. Included is an excellent overview of the potential problem of human exposure to toxic substances as well as a description of how this important method is being used to test chemical substances. 

McCann J, Choi E, Yamasaki E, Ames BN Detection of carcinogens as mutagens in the Salmonella/vaiacosome test Assay of 300 chemicals. Proc Natl Acad Sci USA, 72 5135-5139, 1975... 

Ichinotsubo, D., Mower, H. Mandel, M. (1981b) Mutagen testing of a series of paired compounds with the Ames Salmonella testing system (University of Hawaii at Manoa). In de Serres, F.J. Ashby, J., eds. Progress in Mutation Research, Vol. L Evaluation of Short-Term Tests for Carcinogens. Report of the International Collaborative Program, Amsterdam, Elsevier/North-Holland, pp. 298-301... 

Roldan-Arjona, T., Garcia-Pedrajas, M.D., Luque-Romero, F.L., Hera, C. Pueyo, C. (1991) An association between mutagenicity of the Ara test of Salmonella typhimurium and carcinogenicity in rodents for 16 halogenated aliphatic hydrocarbons. Mutagenesis, 6, 199-205... 

Morita, T., Iwamoto, Y., Shimizu, T., Masuzawa, T. Yanagihara, Y. (1989) Mutagenicity tests with a permeable mutant of yeast on carcinogens showing false-negative in Salmonella assay. Chem. pharm. Bull., 31, 407-409... 

---