Oxidative mutagens

Levin, D.E., Hollstein, M., Christman, M.F., Schwiers. E.A. Ames, B.N. (1982) Anew Salmonella tester strain (TA102) with A.T base pairs at the site of mutation detects oxidative mutagens. Proc. natl Acad. Sci. USA, 79, 7445-7449... 

Contrary to the above reports, Barakat et al. (2003) reported a very weak oxidative mutagenicity in cumin, in the strain TA102... 

Levin D-E, Hollstein M, Christman M-F, Schwiers E-A and Ames B-N (1982) A new Salmonella tester strain with A.T base pairs at the site of mutation detects oxidative mutagens. Proc Nad Acad Sci USA 79 7445-7449 Maron D-M, Ames B-N (1983) Revised methods for the Salmonella mutagenicity test. Mutation Res 113 173-215 McCann J, Springarn N-E, Kobory J and Ames B-N (1975) Detection of carcinogens as mutagens bacterial tester strains with R factor plasmids. Proc Nat Acad Sci USA 72 979-983... 

Tests for gene mutations have been mixed, both in vivo and in vitro. Asbestos fibers were not mutagenic in initial tests of standard strains of Salmonella typhimurium and Escherichia coli (Chamberlin and Tarmy 1977), but mutagenic responses were found in a S. typhimurium strain, TA102, that is especially sensitive to oxidative mutagens (Faux et al. 1994). 

S. typhimurium strain TA102, which detects oxidative mutagens following base pair substitution of AT to GC (211). These findings triggered extensive research activity into the possible roles of O2 and ROS (in particular OH radicals) in the mechanisms of Cr induced genotoxicity (Sections 111.B.5-111.B.7, ni.C.l, and... 

Martinez, A., Urios, A. Blanco, M. (2000) Mutagenicity of 80 chemicals in Escherichia coli tester strains IC203, deficient in OxyR, and its oxyR+ parent WP2 uvrA/pKMIOl detection of 31 oxidative mutagens. Mutat. Res. 467, 41-53. 

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