Salicylate Cream

Charge, one by one, items 1-4 to a melting vessel at 79°-75°C hold molten fat at 70°C with continuous stirring at low speed. 

In a separate vessel, heat 90% of item 5 to 90°C, add and dissolve parabens by stirring. Cool to 65°-70°C. 

In a separate vessel, take the balance of item 5 and sodium hydroxide pellets and sodium phosphate monobasic and dissolve. 

Transfer step 3 to the paraben solution and mix for 5-10 minutes at slow speed and at 65°-70°C. 

Filter solution through polyester cloth and keep aside at 50°C. 

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Benzyl Chloride. Benzyl chloride is manufactured by high temperature free-radical chlorination of toluene. The yield of benzyl chloride is maximized by use of excess toluene in the feed. More than half of the benzyl chloride produced is converted by butyl benzyl phthalate by reaction with monosodium butyl phthalate. The remainder is hydrolyzed to benzyl alcohol, which is converted to ahphatic esters for use in soaps, perfume, and davors. Benzyl salicylate is used as a sunscreen in lotions and creams. By-product benzal chloride can be converted to benzaldehyde, which is also produced directiy by oxidation of toluene and as a by-product during formation of benzoic acid. By-product ben zotrichl oride is not hydrolyzed to make benzoic acid but is allowed to react with benzoic acid to yield benzoyl chloride. 

As of 1991 in the United States, OTC antiacne preparations may contain only a few active dmgs, for example, sulfur [7704-34-9] resorcinol acetate [102-29-4], resorcinol [108-46-3], salicylic acid [69-72-7], and some combinations (52). OTC anti-acne constituents maybe included in a variety of conventional cosmetic preparations, which then become OTC dmgs. These include lotions, creams, solutions, facial makeups, facial cleansers (including abrasive cleansers), and astringents. Products must contain the specified dmgs at the designated concentrations. Compositions of antiacne products have beenpubhshed (53). 

Some simple benzoates are also used as antiseptic agents. Salicylic acid esters are used as antibacterial agents and pain relievers. Analgesic balms, creams. 

Gladstone HB, Nguyen SL, Williams R, Ottomeyer T, Wortzman M, Jeffers M, Moy RL (2000) Efficacy of hydroquinone cream (USP 4%) used alone or in combination with salicylic acid peels in improving photodamage on the neck and upper chest. Dermatol Surg 26(4) 333-337... 

Fig. 16.3. a Severe recalcitrant post-inflammatory hyperpigmentation secondary to acne excorians. b After a series of four salicylic acid 20 and 30% peels and 10% hydroquinone cream... 

Superficial salicylic acids have been shown to be safe and efficacious for treatment of PIH. In a study of five patients with Fitzpatrick s Skin Types V and VI with PIH, pretreatment for 2 weeks with hydroquinone 4% cream followed by a series of five 20-30% salicylic acid chemi-... 

In erythrosis 15% to 25% to 30% salicylic acid peeling should be performed at 3-week intervals for a total of three to four peelings (Fig. 17.14a, b). Suggested topical treatment between peeling includes 0,75% metronidazole cream once a day or 1-2% salicylic acid cream once a day and sunblock creams... 

The influence of a cream containing 20% glycerin and its vehicle on skin barrier properties has been investigated. Recent studies have shown that polymers offer several advantages and can be used in skin care products. Phase diagrams were determined for lactic and isohexanoic hydroxy acids as well as salicylic acid with water, a nonionic surfactant and a paraffinic oil, to outline the influence of hydroxy acids on the structure in a model for a skin lotion. The results showed the influence of the acid to be similar to that of the oil but that the difference in chain length between the two alpha acids had only insignificant influence. The results are discussed from two aspects the structures involved in the lotion as applied, and the action of the lotion residue on the skin after the evaporation of the water. 

Triamcinolone Nystatin (Mycolog ) [Anti-inflammatory Antifungal/Corticosteroid] Uses Cutaneous candidiasis Action Antifungal anti-inflammatory Dose Apply lightly to area bid max 25 mg/d Caution [C, ] Contra Varicella systemic fungal Infxns Disp Cream oint SE Local irritation, hypertrichosis, pigmentation changes Interactions T Effects W/barbiturates, phenytoin, rifampin T effects OF salicylates, vaccines EMS See Triamcinolone OD See Triamcinolone... 

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