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Rushes defined

The high-dose transition is defined as a transition phase in which the individual suddenly increases the doses of stimulants or switches to smoking (e.g., cocaine crack ) or IV route of administration (Gawin and Ellinwood 1988). This change leads to a rapid escalation of plasma levels and intense euphoria (i.e.. rush) often with subsequent increase in dosing frequency. In its most severe form, the high-dose pattern is characterized by binges of... [Pg.324]

Nony et al. 1980 Zwimer-Baier and Neumann 1994). Some of the methods have been shown to be suitable for the determination of the aeetylated metabolites (Bowman and Nony 1981 Nony and Bowman 1980 Nony et al. 1980). The methods of Bimer et al. (1990), Joppieh-Kuhn et al. (1997), and Zwimer-Baier and Neumann (1994) permit the analysis of hemoglobin adduets of 3,3 -diehlorobenzidine and its monoacetyl metabolite. Limits of deteetion for 3,3 -diehlorobenzidine in mine and semm were reported to be as low as 1 to 5 ppb (Bowman and Rushing 1981 Hoffman and Sehmidt 1993 Roberts and Rossano 1982), with detectable concentrations of the aeetylated metabolites somewhat higher. Most of these studies were performed with samples from rats the methods should be tested to determine if they are applieable to samples of human origin. In addition, the levels of these biomarkers associated with exposures to 3,3 -dichlorobenzidine of toxicological concern should be defined in order to increase their utility. [Pg.142]

Psychotropic medication use is associated more with causing difficulties with eating rather than as a treatment for eating disorders. None of the medications investigated in the treatment of primary anorexia nervosa have been shown to be efficacious. Pica is defined as the eating of non-food substances. In the Expert Consensus survey (Rush and Frances, 2000) 63% of the respondents stated that no medication treatment is indicated for this disorder. Should medication be considered, then SSRI medications were most commonly endorsed. Another alternative is treatment with mineral or nutritional supplements, such as zinc or iron. [Pg.624]

The Inventory of Depressive Symptomatology Self Report (IDS-SR) is a 29-item self-rating scale for the evaluation of depressive symptom severity. Each item is rated on a defined four-step scale (0 3). Analysis of sensitivity to change in symptom severity in an open-label trial showed that the IDS-SR was highly correlated with the 17-item HRSD (Rush et at., 1996). [Pg.199]

The first of the organising systems can be labelled an activities approach. In response to the question What is this destination like , listings of available activities in an area are frequently drawn up, thus defining both the commercial and the public opportunities available to visitors to the region. At times the overall listing is supplemented by profiles of activities for a particular market. For example, adventure-oriented tourists may be targeted in publications that list companies offering adrenalin-rush opportunities. [Pg.90]

The maximum difference of thermodynamic rushes is, obviously, corre spondent to the occurrence of the bottleneck in the stepwise reaction. Therefore, the rate limiting step in a sequence of chemical transformations is naturally to define as some elementary step with the maximum differ ence of thermodynamic rushes (or that has nearly the same chemical potentials) of the reaction groups involved in the transformation. Horiuti first mentioned this specificity of the stepwise reaction bottleneck. [Pg.48]

However, the stationary states of the catalyst may be stable far from thermodynamic equilibrium—for example, due to the existence of the positively defined Lyapunov function for the given catalytic process (see Section 3.4). In particular, there are always stable stationary states of cata lytic systems with an arbitrary set of monomolecular transformations of catalytic intermediates ( the reactant-active center complexes) or any other set of these transformations, when they are linear in respect to the intermediate concentration or its thermodynamic rush. [Pg.251]

To be realistic, synchronism must be defined differently for attackers They may send their own messages last in a round, so that they can already base their decision on the messages sent by others. This is called rushing attackers, see [Beav91, MiRo91]. [Pg.46]

It may seem obvious to state that a new product should be adequately defined before any serious product development is undertaken. In many cases, the value of the design phase is often underestimated in the rush to start development and get products to the market quickly. This can result in much wasted time and valuable resources. It can also lead to reduced staff motivation if a product is developed that is not wanted or if the product definition is constantly changing during development. The quality of the design activities can strongly influence the success of development of the right product to the market and ultimate return on investment. [Pg.157]

Localized errors (loops and connectivity). Loops are often flexible and in these cases poorly defined in the electron-density maps. Crystallographers, trying to build these loops, sometimes connect wrong parts of the protein and place loops into density which do not belong to those loops. These kinds of errors occur most often with hot structures , when people rush to solve the structure in the shortest possible time in order to stay ahead of the competition. [Pg.428]

Sherwood S W, Rush D, Ellsworth J L, et al. (1988). Defining cellular senescence in IMR-90 ceils a flow cytometric analysis. Proc. Natl. Acad. Sci. USA. 85 9086-9090. [Pg.1370]

From the start, program manager actions helped define the event as one not to be overly concerned about. For example, their decision to not work the problem over the first weekend contrasted sharply with that of engineers and signaled their initial lack of concern for the seriousness of the issue. The Mission Evaluation Room manager wrote I also confirmed that there was no rush on this issue and that it was okay to wait till the film reviews are finished on Monday to do a TPS review (CAIB, 2003 142 emphasis added). But the social influence didn t stop there. [Pg.195]

Writing a description of a problem is a disciplining activity that focuses thinking and enhances understanding of a problem s facets. Writing encourages you and others to think deeper and wider. This, in turn, often leads to solutions in that a problem well defined is partially solved. Whatever your personal style, don t rush to your supervisor immediately upon discovering a problem. Think about it, perhaps write about the problem, and identify at least one feasible solution. Then talk to your supervisor. This will enable both you and your supervisor to make the best use of your collective time. Expect the same of people who report to you. [Pg.36]

Recognizing that the relationship between population and network capacity is often imprecise, networks are designed to capacity levels largely determined by population and economic activity, whether defined as rush hour vehicle traffic, sewerage flows, or school enrollment. As population and jobs drop, networks typically develop excess capacity, visible in empty streets or empty school buildings (Moss 2008). From 2005 to 2008, Detroit public school enrollment dropped by 35,000. ° In similar vein, a bicyclist recently wrote, one night a little over a year ago, crossing Woodward Avenue, I crashed my bicycle. As I flew head over heels across Detroit s... [Pg.1868]

Of course, this principle relates to many behaviors. In Chapter 14, it was used to explain why people often do not rush to help in a crisis. If there are more perceived costs than benefits to intervening, actively caring behavior is unlikely. Therefore, a prime strategy for increasing safety and actively caring behaviors is to overcome the costs (negative consequences) with benefits (positive consequences). Various kinds of consequences are defined by the next principle. [Pg.486]

Photosynthesis and photorespiration are of the hipest orders of scientific complexity and the application of methanol to crops poses certain need for mechanistic studies as well as continual practical consideration and reduction of safety and handling risks. Therefore, it should be precautioned that end users should not rush out to spray methanol It is hoped that a defined formulation and protocol will be ready for the grower after all data have been carefully digested. Then, and only then, with custom-designed distribution of methanol products for crops, can humanity begin to gain maximum benefit and enjoyment from this discovery. [Pg.259]

I think it is easy to see differences between us and those ordinary engineers, or whatever you call them. They approach [product development[ by rushing into developing different solutions, without having defined the need we are seeking to solve with the product. This means that we end up with two parallel tracks. [Pg.210]

It is unnecessary to provide further detail of the apparatus since some excellent descriptions are in the literature [14-20]. These allow the construction of simple and hence flexible systems, yet thoroughly examine the theory of hght measurement so that the investigator can choose the most suitable apparatus. With the growth of interest in luminescence-based immunoassay methods, there has been a rush by many manufacturers to produce luminometers to serve this potentially lucrative market. The instruments and the addresses of the companies are listed in reference 2. It is important to point out however, that these instruments are rarely suitable for research work in the field of chemiluminescence itself. They are sensitive and where the analytical requirements are well defined, they can be very convenient. More flexibility is required in the apparatus used for investigations of the fundamental light reaction and its mechanism. [Pg.193]


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