Role of tyrosine

MAJUMDAR A p (1990) Role of tyrosine kinases in gastrin induction of ornithine decarboxylase in colonic mucosa. Am J Physiol. 259 (4 Ptl) G626-G630. 

The role of tyrosine kinase signaling in actin cytoskeleton regulation is well established (166-171), and certain steps in the activation pathways of both Rac 1 and RhoA, two molecules known to modulate actin function, may also require tyrosine kinase activity (172,173). In fact, two recent reports have also indicated... 

Garland, L. G. (1992). New pathways of phagocyte activation The coupling of receptor-linked phospholipase D and the role of tyrosine kinase in primed neutrophils. FEMS Microbiol. Immunol. 105,229-38. 

Muller et al.understand better the role of tyrosine in the structure and biological function of MDH. Resolution of the protein absorption spectrum, using iV-acetylphenylalanine ethyl ester in dioxane and A-acetyltyrosine ethyl ester in dioxane or 0.1 M phosphate buffer to model the effect of the local environments of the chromophoric groups, indicated that both the pig and the... 

Phosphorescence and ODMR are additional spectroscopies that can be used to investigate intramolecular interactions that affect tyrosine residues in proteins and polypeptides/215,216) An example is tyrosine and tyrosinate in horse liver alcohol dehydrogenase.(202) The same approach has been used to study the role of tyrosine in the mechanism of action of carboxypeptidase B.(21/,218) jn botli these proteins, as in other proteins which contain both... 

R. Mayer, F. Toulme, T. Montenay-Garestier, and C. Helene, The role of tyrosine in the... 

A. Dubus, S. Normarj, M. Kania, M. G. P. Page, The Role of Tyrosine 150 in Catalysis of /3-Lactam Hydrolysis by AmpC /3-Lactamase from Escherichia coli Investigated by Site-Directed Mutagenesis , Biochemistry 1994, 33, 8577-8586. 

Cunnick, J.M., Dorsey, J.F., Standley, T., Turkson, J., Kraker, A.J., Fry, D.W., Jove, R., and Wu, J., 1998, Role of tyrosine kinase activity of epidermal growth factor receptor in the lysophosphatidic acid-stimulated mitogen-activated protein kinase pathway, J. Biol. Chem. 273 14468-14475. 

Tyrosine kinases are important mediators of the signaling cascade, determining key roles in diverse biological processes like growth, differentiation, metabolism and apoptosis in response to external and internal stimuli. Recent advances have implicated the role of tyrosine kinases in the pathophysiology of cancer. 

McCall, M. N., and Easterbrook-Smith, S. B. (1989). Comparison of the role of tyrosine residues in human IgG and rabbit IgG in binding of complement subcomponet Clq. Biochem.J. 257, 845-851. 

Price KL, Lummis SC. The role of tyrosine residues in the extracellular domain of the 5-hydroxytiyptamine3 receptor. J Biol Chem 2004 279(22) 23,294-23,301. 

Zhou, Y. Y., Yao, J. A., and Tsen, G. N. 1997. Role of tyrosine kinase activity in cardiac slow delayed rectifier channel modulation by cell swelling. Pfliigers Arch. 433 750-757. 

Asakura, T., Suita, K., Kameda, T., Afonin, S., and Ulrich, A.S. "Structural role of tyrosine in Bombyx mori silk fibroin, studied by solid-state NMR and molecular mechanics on a model peptide prepared as silk I and II". Magn. Reson. Chem. 42(2), 258-266 (2004). 

Feeney, R. E., and St. K. Komatsu Role of Tyrosines in Metal-Complexing Properties of Transferrins. (To be presented at the 152nd meeting of the American Chemical Society, September 12-18, 1966, New York, N. Y.) The role of hydroxyls (tyrosyls) in the binding of metals by human serum transferrin and chicken ovotransferrin has been shown by chemical means. Acetylation of the transferrins with N-acetyl imidazole inactivated the metal-binding activity. Deacetylation of the acetylated transferrins with hydroxylamine reactivated the transferrins. 

Jockel, P., Schmid, M., Choinowski, T., and Dimroth, P. (2000) Essential role of tyrosine 229 of the oxaloacetate decorboxylase p-subunitin the energy coupling mechanism of the Na+ pump, Biochemistry, 39, 4320-4326. 

Kumar, A., Tanaka, T., Lee, Y. M., and Preiss, J. 1988. Biosynthesis of bacterial glycogen Use of site-directed mutagenesis to probe the role of tyrosine 114 in the catalytic mechanism of ADPglucose synthetase from Escherichia coli. J. Biol. Chem. 263, 14634-14639. 

Macheroux, P., Kieweg, V., Massey, V., S derland, E., Stenberg, K., and Lindqvist, Y., 1993, Role of tyrosine 129 in the active site of spinach glycolate oxidase. Fur. J. Biochem. 213 1047nl054. 

Finkele, U., Lauterwasser, C., Zinth, W., Gray, K. A., and Oesterhelt, D., 1990, Role of tyrosine M210 in the initial charge separation of reaction centers of Rhodobacter sphaeroides. Biochemistry, 29 8517-8521. 

Audette M, Blouquit Y, Houee-Levin C. (2000) Oxidative dimerization of proteins Role of tyrosine accessibility. Arch Biochem Biophy 376 217-220. 

Ito K, Tomita T, Barnes PJ, Adcock IM. Oxidative stress reduces histone deacetylase (HDAC)2 activity and enhances IL-8 gene expression Role of tyrosine nitration. Biochem. Biophys. Res. Commun. 2004 315 240-245. 

In addition to the serine-threonine phosphorylation sites modulated by PKC and PKA, a basal state of tyrosine phosphorylation exists in platelet TP receptors, as in bradykinin receptors, and this phosphorylation increases on agonist stimulation (166). The tyrosine kinase responsible for this pho horylation, as well as that of the parallel phosphorylation of phosphatidylinositol 34dnase (PIj4dnase), that occurs on agonist stimulation, is unknown, but p27 known to be activated by TP receptor agonists (167), is a candidate (166). It is also possible that PI, kinase itself might phosphorylate TP receptors. The functional role of tyrosine kinase-mediated phosphorylation of TP receptors is unknown. 

Structural and Functional Roles of Tyrosine-50 of Yeast Guanylate Kinase... 

Lavendustin A and derivatives have been used to study the pathophysiological role of protein kinases. For instance, lavendustin A was used to study the potential role of tyrosine kinases in the regulation of wall stretch-induced atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) secretion. Because lavendustin A is selective for t5n-osine kinases, the data obtained under these conditions showed that this kind of kinase is implicated in regulating cardiac hormone secretion. However, it is still unclear which tyrosine kinase is responsible for wall stretch-induced cardiac hormone secretion [111]. 

Hu ZW, Shi XY, Lin RZ, Chen J, Hoffman BB. ar Adrenergic receptor stimulation of mitogenesis in human vascular smooth muscle cells role of tyrosine protein kinases and calcium in activation of mitogen-activated protein kinase. J Pharmacol Exp Ther 1999 290 28-37. 

BJ Hallahan, JHA Nugent, JT Warden and MCW Evans (1992) Investigation of the origin of the S3 EPR signal from the oxygen-evolving complex of photosystem 2 The role of tyrosine Z. Biochemistry 31 4562-4573... 

Hunter T (1998) The role of tyrosine phosphorylation in cell growth and disease. Harvey Lect 94 81-119... 

T Higuchi, Y Ito, I Kawamura. /J-Hydroxyphenylpropane components of grass lignin and the role of tyrosine ammonia-lyase in its formation. Phytochemistry 6 875-881, 1967. 

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