Role of fatty acids

The role of fatty acids as oxidizable fuels for brain metabolism is negligible, but ketone bodies, derived from fatty acid oxidation, can be utilized, particularly in the neonatal period. Diseases of carbohydrate and fatty acid metabolism may affect the brain directly or indirectly [1,10]. 

Cooper, J. E., and E. E. Bray, A Postulated Role of Fatty Acids in Petroleum Formation, Geochim. Cosmochim. Acta, 27, 1113-1127 (1963). 

Harper, W.J., Sohn, S., Da Jou, K. (1996) The role of fatty acids in the aroma profiles of Swiss cheese as determined by an electronic nose. In Olfaction and Electronic Nose, 3rd International Symposium, Toulouse. 

F atty acids, as components of phospholipids, are important structural elements of biological membranes and, like carbohydrates, are important sources of energy. In this chapter we focus on the role of fatty acids in energy metabolism. We see that fatty acids are both assembled and de-... 

Adhikary A, Bothe E, Jain V, von Sonntag C (2000) Pulse radiolysis of the DNA-binding bisbenzimid-azole derivatives Hoechst 33258 and 33342 in aqueous solution. Int J Radiat Biol 76 1157-1166 Aikens J, DixTA (1991) Perhydroxyl radical (HOO ) initiated lipid peroxidation. The role of fatty acid hydroperoxides. J Biol Chem 266 15091-15098... 

Murakami K. and Routtenberg A. (2003). The role of fatty acids in synaptic growth and plasticity. In Peet M., Glen L., and Horrobin D. F. (eds.), Phospholipid Spectrum Disorders in Psychiatry and Neurology. Marius Press, Camforth, Lancashire, pp. 77-92. 

Membrane transport small molecules (E3) Structures and roles of fatty acids (Kl)... 

Partial inhibition of glycolysis by saturated fatty acids has been observed in Ehrlich ascites tumor cells. Palmitate and acetate decreased glutamate formation from glutamine (the first step in glutaminolysis) in this cell line, suggesting the possible role of fatty acids as an alternative energy source (Butler et al., 1999). 

It was recently reported that women with a higher intake of n-3 fatty acids tend to have a lower risk of dry eye, based on information gathered from a questionnaire on dietary habits. A completed questionnaire was received from over 32,000 subjects in the Women s Health Study. A high dietary intake ratio of n-6 to n-3 fatty acids was associated with a greater prevalence in dry eye. Although the questionnaire results suggest intake of n-3 fatty acids and the ratio of their consumption to n-6 fatty acids can affect the amount of inflammatory activity in the body, there has been no systematic study to establish the role of fatty acids in the treatment of dry eye. 

Figure 1 Role of fatty acid desaturases in the biosynthesis of unsaturated fatty acids Typical fatty acids found as components of cell membranes and storage lipids (a) signaling agents (b) and plant-derived antifeedants (c).

G. Boden, Role of fatty acids in the pathogenesis of insulin resistance and NIDDM, Diabetes, 1997, 46, 3-10. 

Simopoulos AP. The role of fatty acids in gene expression health implications. Ann Nutr Metab 1996 40 303-311. 

Sellner P, Chu W, Glatz J, Berman NE. Developmental role of fatty acid-binding proteins in mouse brain. Brain Res Developmental Brain Res 1995 89 33 6. 

K. Nettesheim, E. Wisman etal. (2001). Functional analysis of the LACERATA gene of Arabidopsis provides evidence for different roles of fatty acid w-hydroxylation in development. Proc. Natl. Acad. Sci. USA 98, 9694-9699. 

IV. THE ROLE OF FATTY ACIDS AND KETONE BODIES IN FUEL HOMEOSTASIS... 

Cooper, J.E. and Bray, E.E., 1963. A postulated role of fatty acids in petroleum formation. Geochim. Cosmochim. Acta, 27 1113—1127. 

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