Fatty acid roles

Dutta-Roy, A.K. (2000) Cellular uptake of long chain fatty acids role of membrane associated fatty acid binding/transport proteins. Cellular and Molecular Life Sciences (in press). 

Fatty acid role(s) Synthesis, storage, signaling Storage, oxidation, signaling... 

Chen, L.Y., Lawson, D.L., and Mehta, J.L. (1994) Reduction in Human Neutrophil Superoxide Anion Generation by n-3 Polyunsaturated Fatty Acids Role of Cyclooxygenase Products and Endothelium-Derived Relaxing Factor, Thromb. Res. 76,317-322. 

Watkins, B.A., Lippman, H.E., Le Bouteiller, L., Li, Y., and Seifert, M.F. (2001) Bioactive Fatty Acids Role in Bone Biology and Bone Cell Function, Prog. Lipid Res. 40, 125-148. 

Fatty acids normally occur naturally as esters fats oils phospholipids and waxes all are unique types of fatty acid esters There is however an important class of fatty acid derivatives that exists and carries out its biological role m the form of the free acid This class of fatty acid derivatives is described m the following section... 

Each component of blood has a function ia the body. Red cells transport oxygen and carbon dioxide between the lungs and cells ia the tissues. White cells function as defense of the body. Platelets are important for hemostasis, ie, the maintenance of vascular iategrity. Plasma, an aqueous solution containing various proteias and fatty acids, transports cells, food, and hormones throughout the body. Some proteias ia plasma play a role ia clotting, others are messengers between cells. 

In the chloride shift, Ck plays an important role in the transport of carbon dioxide (qv). In the plasma, CO2 is present as HCO, produced in the erythrocytes from CO2. The diffusion of HCO requires the counterdiffusion of another anion to maintain electrical neutraUty. This function is performed by Ck which readily diffuses into and out of the erythrocytes (see Fig. 5). The carbonic anhydrase-mediated Ck—HCO exchange is also important for cellular de novo fatty acid synthesis and myelination in the brain (62). 

Cysteine [52-90 ] is a thiol-bearing amino acid which is readily isolated from the hydrolysis of protein. There ate only small amounts of cysteine and its disulfide, cystine, in living tissue (7). Glutathione [70-18-8] contains a mercaptomethyl group, HSCH2, and is a commonly found tripeptide in plants and animals. Coenzyme A [85-61-0] is another naturally occurring thiol that plays a central role in the synthesis and degradation of fatty acids. 

Kim, K-H., et al., 1989. Role of rever.sible pho.sphorylation of acetyl-CoA carboxyla.se in long-chain fatty acid. syndie.sis. The EASEB Journal 3 22 0-2256. 

Problem 29.5 Evidence for the role of acetate in fatty-acid biosynthesis comes from isotope-labeling experiments. If acetate labeled with 13C in the methyl group ( CFtyCC H) were incorporated into fatty acids, at what positions in the fatty-acid chain would you expect the, 3C label to appear ... 

FATP5 KO mice have been characterized in two studies focusing on the role of FATP5 in hepatic lipid and bile metabolism. LCFA uptake in primary hepato-cytes isolated from FATP5 KO mice was reduced by 50% and hepatic lipid content in the KO mice was significantly reduced despite an increased fatty acid de novo biosynthesis. Detailed analysis of the hepatic lipidome of FATP5 KO mice revealed significant... 

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