Research hypothesis development

However, failure to disprove the null hypothesis does not mean we can reject the alternative hypothesis and accept the null hypothesis. This is a subtle but extremely important point in hypothesis testing, especially when hypothesis testing is used to identify factors in research and development projects (see Section 1.2 and Table 1.1). 

Numerous antidepressants were synthesized, developed and marketed on the basis of the serotonin hypothesis. The selective serotonin reuptake inhibitors (SSRIs) are similarly effective as the older tricyclic antidepressants, but have the advantage of being less toxic and not inducing anticholinergically mediated side effects (Chapter 1). From the scientific point of view1 they represent an example of mechanistic, hypothesis-driven research and development in psychopharmacology (Chapter 2). 

Wraith, J.M. and Or, D. (1999) Temperature effects on soil bulk dielectric permittivity measured by time domain reflectometry Experimental evidence and hypothesis development, Water Resources Research 35 Suppl. 2, 361-369... 

Consider a study where three doses of a new antihypertensive drug are to be compared, and three groups of subjects will each receive one dose. Such a study may be performed in earlier phase drug development to determine the most appropriate dose for subsequent larger trials. The research question, research hypothesis, and null hypothesis in this case would be ... 

Throughout the semester, the class reads chapters 1 to 10 of Robert Hazen s book and submit chapter summaries which are discussed in class. The book helps students understand the current state of research, and develop an understanding of the interdisciplinary nature of the research, the process of scientific inquiry, the importance of data and experimental verification of a hypothesis, and the highs and lows of scientific research. 

This paper reports first results of research and development work to achieve nitrogen oxide reduction under lean diesel exhaust gas conditions. Much attention is paid to the influence of operation conditions on catalyst performance. A major part of the paper deals with the influence of the hydrocarbon component, the hydrocarbon concentration and the HC/NO ratio on the activity of a special developed platinum based catalyst. Other aspects discussed are a spectroscopic characterization and a selectivity study. A hypothesis of a "dual-site" reaction mechanism for NOx-reduction in lean diesel exhaust gas precious metal based catalyst is established. Finally, first promising results on the performance of the catalyst system in a vehicle dynamometer test are given. 

Further research and development work it is necessary to proof this hypothesis. Especially the identification of the adsorbed hydrocarbon species is a major task for this work. 

When a hypothesis has been developed, when a chemical synthesis program has been developed, when an exploratory preclinical program has been completed, and when the clinical study evaluation all contribute to the data that generates an approved NDA, all the disciplines of research and development come together to provide a tool to the physician to improve the life of his or her patients. 

Frescholtz 2002). Although ongoing and new planned field and laboratory studies are designed to further test this hypothesis, we feel that it is warranted at this time to develop a pilot-scale network of aimual ecosystem fluxes of THg in TF and LF as indicators of total atmospheric deposition. These fluxes can then be compared with measured wet plus modeled diy deposition based on both inferential and regional-scale models to develop independent estimates of total atmospheric deposition for forested catchments. We also believe that this approach could eventually be applied to a national network, such as the MDN. Although this method is best aimed at forested sites, ongoing research will address methods appropriate for other ecosystems. 

---