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Reproduction study in rats

EPA (1988a) has discussed the results of two reproductive studies in rats. Results of these studies have not been presented in peer-reviewed scientific journals and are not available to the public. If these data become available, they will provide valuable information on the reproductive hazards of methyl parathion. [Pg.125]

In a three - generation reproduction study in rats, Beliles et al. (1980) found that exposure of animals to acrylonitrile in drinking water at 70 mg/kg/day resulted in reduced viability and lactation indices in all generations. The authors considered the reduced pup indices to be the result of maternal toxicity, possibly related to reduced milk production due to decreased water intake by the dams. Fostering of pups on untreated dams lessened pup mortality. Measurement of acrylonitrile in the pups was not performed. [Pg.47]

Reproductive Effects. There are no data available on the reproductive effects in humans. However, a three-generation reproduction study in rats showed that acrylonitrile has an effect on reproduction. [Pg.58]

There were no effects on the fertility or the incidence of anomalies or growth in offspring in a one-generation reproduction study in rats with an aerosolized repellent containing 3.6% allethrin for 8 h/day [157]. [Pg.103]

Srivastava A, Srivastava MK, Raizada RB (2006) Ninety-day toxicity and one-generation reproduction study in rats exposed to allethrin-based liquid mosquito repellent. J Toxicol Sci 31 1-7... [Pg.112]

In multigeneration reproduction study in rats decreased pup weights occurred in the Fi and F2 generation at the 7000-ppm exposure level. ... [Pg.194]

Scbweitz BA, Norris JM, Kociba RJ, et al Results of a reproduction study in rats fed diets containing bexacblorobutadiene. Toxicol Appl Pharmacol 2 387-398, 1977... [Pg.373]

Metbomyl did not produce embryotoxic or teratogenic effects in rats or rabbits at doses that caused maternal toxicity No effects on fertility, gestation, or lactation indices were found in three-generation reproduction studies in rats. ... [Pg.443]

Kaneda M, Hatakenaka N, Teramoto S, et ah A two-generation reproduction study in rats with methyl bromide-fumigated diets. Food Chem Toxicol 31 533-542, 1993... [Pg.459]

No evidence of teratogenesis or adverse fetal effects was apparent in the offspring of rats exposed at concentrations of 40 ppm for 6 hours/day from day 6 to day 15 of pregnancy." In a two-generation reproduction study in rats, a decrease in the fertility index of the Fq and Fi generations occurred. [Pg.517]

Harleman JH, Seinen W. 1979. Short-term toxicity and reproduction studies in rats with hexachloro-(1,3)-butadiene. Toxicol AppI Pharmacol 47 1-14. [Pg.104]

Intermediate oral MRLs for all three cresol isomers could have been calculated based on NOAEL values of 30 mg/kg/day for neurological effects in two-generation reproductive studies in rats (BRRC 1989a, 1989b, 1989c). However, these intermediate oral MRLs were not derived because they would have been less protective than the acute MRLs. This apparent anomaly reflects the fact that lower doses were employed in the developmental toxicity study used as the basis for the acute MRLs than in longer term studies. Dermal MRLs were not derived for cresols due to the lack of an appropriate methodology. [Pg.52]

Dow Chemical Company. 1975. Results of a reproduction study in rats maintained on diets containing decabromodiphenyl oxide. Submitted to U.S. EPA under TSCA Section 8D, Fiche no. OTS0522252. [Pg.419]

Nitschke, K.D., Eisenbrandt, D.L., Lomax, L.G. Rao, K.S. (1988) Methylene chloride Two-generation inhalation reproductive study in rats. Fundam. appl. Toxicol., 11, 60-67... [Pg.309]

A mortality rate of 30% was observed in Wistar rats treated by gavage with 6 mg/kg white phosphorus (Torrielli et al. 1974). The oral LD50 value for Charles-River rats was 3.03 mg/kg for females and 3.76 mg/kg for males (Lee et al. 1975). A mortality rate of 20-35% was observed in mice treated by gavage with 5-6 mg/kg (Hurwitz 1972). LD50 values of 4.82 mg/kg and 4.85 mg/kg were reported for female and male mice, respectively (Lee et al. 1975). In two separate one-generation reproduction studies in rats (IRDC 1985 ... [Pg.50]

Bio/dynamics. 1991. A one-generation reproduction study in rats with elemental phosphorus Vols. I and II (Final Report) with pathology report. Report BD-89-153. U S. EPA Fiche ... [Pg.217]

Condray JR. 1985. Elemental yellow phosphorus one-generation reproduction study in rats. IR-82-215 IRD No. 401-189. Monsanto Company, St. Louis, MO. [This study and IRDC 1985 are the same studies ]... [Pg.219]

IRDC. 1985. One-generation reproduction study in rats with elemental phosphorus. EPA/OTS Public Files, Washington, DC. IR-82-215. Fiche OTS0518525-1. [Unpublished study]... [Pg.223]

Reproduction studies in rats and rabbits Reproductive effects are evaluated on the gametes, in the developing organism (teratology), and in the progeny. These studies are generally conducted for all pharmaceuticals, but on a case-by-case basis for biopharmaceuticals. [Pg.854]

A standard reproductive study in rats showing no effect on the ability of males to impregnate females should not be considered to support a conclusion that there is no male reproductive toxicity in all species. Unlike humans, rodents produce sperm in numbers that greatly exceed the minimum requirements for fertility. A substantial reduction in sperm production in rodents may not compromise fertility in rodents while a less severe reduction in human males could cause reduced fertility. [Pg.82]

Multigeneration reproductive studies in rats (Sasser et al, 1989b) and teratology studies in rats and rabbits (Hackett et al, 1987) given lewisite by gastric intubation were negative or compromised by concurrent maternal toxicity. [Pg.103]

A two-generation reproductive study in rats with a teratology phase... [Pg.31]

A three-generation reproductive study in rats reported testicular atrophy but no effect on reproduction. No mutagenic or teratogenic effects have been reported in animals. Chlorobenzilate has produced hepatocellular carcinoma in mice but the evidence for carcinogenicity in rats is equivocal. [Pg.560]

One oral continuous breeding study was perfonned in mice, a drinking water study (Heindel et al. 1990) that has also been summarized in Morrissey et al. (1988, 1989). An oral reproductive study in rats and reproductive studies in two species conducted by the inhalation and dermal routes (which are the two routes most relevant for humans) would help to complete tlie picture of reproductive effects of 2-butoxy-ethanol in animals and help to determine whether 2-butoxyethanol exposure presents a reproductive hazard to humans. [Pg.297]

Monsanto, One-Generation Reproductive Study in Rats with Elemental Phosphorus with Attachments and Cover Letter Dated 010990, Monsanto Co., EPAOTS0518525-1, 1990. [Pg.174]


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See also in sourсe #XX -- [ Pg.231 ]




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