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Reproduction study, three-generation

In a three-generation reproduction study with DOSS on rats [76] it was shown that administering DOSS in the diet of three successive generations of rats at levels of 0.5% and 1.0% caused a reduction in body weight for parental males in all generations and for FI and F2 females. However, the reduced body weight did not interfere with development of normal reproductive performance. [Pg.536]

In a three - generation reproduction study in rats, Beliles et al. (1980) found that exposure of animals to acrylonitrile in drinking water at 70 mg/kg/day resulted in reduced viability and lactation indices in all generations. The authors considered the reduced pup indices to be the result of maternal toxicity, possibly related to reduced milk production due to decreased water intake by the dams. Fostering of pups on untreated dams lessened pup mortality. Measurement of acrylonitrile in the pups was not performed. [Pg.47]

Reproductive Effects. There are no data available on the reproductive effects in humans. However, a three-generation reproduction study in rats showed that acrylonitrile has an effect on reproduction. [Pg.58]

Beliles RP, Paulin HJ, Makris NG, et al. 1980. Three-generation reproduction study of rats receiving acrylonitrile in drinking water. Chemical Manufacturers Association. Washington, DC. LBI Project No. 2660, February. [Pg.98]

Murray, F.J., F.A. Smith, K.D. Nitschke, C.G. Humiston, R.J. Kociba, and B.A. Schwetz. 1979. Three-generation reproduction study of rats given 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the diet. Toxicol. Appl. Pharmacol. 50 241-252. [Pg.1063]

In a dominant lethal test, treatment of male mice with a single oral dose of 5 mg/kg disulfoton had no effect on male fertility (Herbold 1980). In a three-generation reproductive study, exposure of male and female rats to disulfoton in the diet at 0.5 mg/kg/day resulted a "slight" reduction of litter sizes in... [Pg.79]

Serota DG, Hoberman AM, Friedman ALA, Gad SC Three-generation reproduction study with caprolactam in rats, f Appl Toxicol 8 285-293, 1988... [Pg.116]

Metbomyl did not produce embryotoxic or teratogenic effects in rats or rabbits at doses that caused maternal toxicity No effects on fertility, gestation, or lactation indices were found in three-generation reproduction studies in rats. ... [Pg.443]

A three-generation reproductive study in rats reported testicular atrophy but no effect on reproduction. No mutagenic or teratogenic effects have been reported in animals. Chlorobenzilate has produced hepatocellular carcinoma in mice but the evidence for carcinogenicity in rats is equivocal. [Pg.560]

There was an increase in fetal deaths and abortions at the highest dose tested, 1900 mg kg body weight per day. The NOAEL in a three-generation reproduction study conducted in rats was 500 ppm in the feed (equivalent to 29 mg kg body weight per day), based on reduced growth of pups and a slight increase in the number of pups of the F3 litters that were born dead. [Pg.1644]

K, MacKenzie, S. Hen wood, G. Foster, F. Akin, R. Davis, P. DeBaecke, G, Sisson, G. McKinney. Three-generation reproduction study with dioctyl sodium sulfosucci-naie in rats. Fund. Appl. Toxicol. 15(1) 53-62, 1990. [Pg.17]

Grant, D. Gaunt, I. F. Three-generation reproduction study on carmine of cochineal in the rat. Food Chem. Toxicol. 1987, 25, 903-912. [Pg.91]

See other pages where Reproduction study, three-generation is mentioned: [Pg.361]    [Pg.432]    [Pg.58]    [Pg.92]    [Pg.196]    [Pg.129]    [Pg.116]    [Pg.238]    [Pg.17]    [Pg.19]    [Pg.386]    [Pg.432]    [Pg.361]    [Pg.156]    [Pg.194]    [Pg.2115]    [Pg.121]    [Pg.856]    [Pg.1451]    [Pg.199]    [Pg.128]    [Pg.130]    [Pg.30]    [Pg.36]    [Pg.36]   
See also in sourсe #XX -- [ Pg.17 , Pg.19 ]



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