Region Variability

Random Functions and Regionalized Variables. In univariate statistics, an observation y. is defined as a realization of a random... 

Matheron, G. "The Theory of Regionalized Variables and Its Applications" Ecole des Mines de Paris Fontainebleau, France, 1971 No. 5. 

Fig. 6. Relationship between semivariance y and autocovariance q for a stationary regionalized variable. Oq is the variance of the observations, or the autocovariance at lag 0. For values of t beyond the range, y(x) = oj...

Chawla, G., Gupta, P., Koradia, V., and Bansal, A. K. Gastroretention a means to address regional variability in intestinal drug absorption. Pharm. Tech. 27 50-68, 2003. 

Kanda, J., Saino, T., and Hattori, A. (1985). Nitrogen uptake by natural populations of phytoplankton and primary production in the Pacific Ocean Regional variability of uptake capacity. Limnol. Oceanogr. 30, 987-999. 

Rose K. A., Cook R. B., Brenkert A. L., Gardner R. H., and Hettelingh J. P. (1991b) Systematic comparison of ILWAS, MAGIC, and ETD watershed acidification models 2. Monte Carlo analysis under regional variability. Water Resour. Res. 27, 2591-2603. 

Boutin J., Etcheto J., Merlivat L., and Rangama Y. (2002) Influence of gas exchange coefficient parameterisation on seasonal and regional variability of CO2 air-sea fluxes. Geophys. Res. Lett, article no. 1182. 

Lutz M., Dunbar R., and Caldeira K. Regional variability in the vertical flux of particulate organic carbon in the ocean interior. Global Biogeochem. Cycles (in press). 

Ahiksson A. (2001) Regional variability of Cd, Hg, Pb and C concentrations in different horizons of Swedish forest soils. Water Air Soil Pollut. Focus 1, 325-341. 

Corral-Debrinski M, Horton T, Lott MT, Shoffner JM, Beal MF, Wallace DC. Mitochondrial DNA deletions in human brain regional variability and increase with advanced age. Nature Genet 1992 2 324-9. 

Dr S. Walker of CMR approached European and US companies for information on 21 drugs available in the three regions. Within this narrow sample, only one drug had genetic polymorphism, but even this did not translate to ethnic variations. Three other drugs showed regional variability in PK, but these were attributable to different formulations, different sample times and reduction of the initial dose. The CMR survey confirmed that the reported levels of adverse events were lower in Japanese patients, even when adjusted for dose - a cultural variation. 

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