Variable regions heavy chain disease

Previous studies by Coker et al. [41] showed evidence that a local clonal expansion, somatic hypermutation and class switching occurs in the nasal mucosa. More specifically, they found a biased use in the repertoire of IgE heavy-chain variable regions (VH) [44], The significant bias in tissue towards Vh5 suggests that a local event, possibly superantigens, may cause the VH5 bias. Such a Vh5 bias was also found in other diseases, especially in atopic dermatitis, a disease mediated by S. aureus and its enterotoxins. 

---