Light chains variable regions

Human clone 7E3 immunoglobulin Light chain variable region (VkJ)... 

Hodgkin s lymphoma partial cds GI 9857752 Mus musculus anti-human transferrin IgGi light chain variable region (Ig VL) mRNA, partial cds GI 786586 PDB ID ICLY complexed with Lewis Y nonoate methyl ester... 

Recombinant IgGa heavy chain GI 9857758. IgGi light chain variable region CDR... 

Malcolm, S., Barton, P., Murphy, C., Ferguson-Smith, M.A., Bentley, D.L., Rabbits, T.H. (1982). Localization of human immunoglobulin K light chain variable region genes to the short arm of chromosome 2 by in situ hybridization. Proc. Natl. Acad. Sci. USA 79,4957-4961. 

Sanchez, P., Marche, P.N., Le Guem, C., Cazenave, P.-A. (1987). Structure of a third murine immunoglobulin X light chain variable region that is expressed in laboratory mice. Proc. Natl. Acad. Sci. USA 84,9185-9188. 

Seising, E. Storb, U. (1981 b). Somatic mutation of immunoglobulin light-chain variable-region genes. Cell 25,47-58. 

Crouzier, R., T. Martin, and J. L. Pasquali. 1995. Heavy chain variable region, light chain variable region, and heavy chain CDR3 influences on the mono- and polyreactivity and on the affinity of human monoclonal rheumatoid factors. J. Immunol. 154 4526-4535. 

Fig. 2. The light chain variable region is encoded by two separate gene segments, V and J. The heavy chain variable region is encoded by three gene segments, V, D and J.

Recinos, A., Ill Silvey, K. J. Ow, D. J. Jensen, R. H. Stanker, L. H., Sequences of cDNAs encoding immunoglobulin heavy- and light-chain variable regions from two anti-dioxin monoclonal antibodies. Gene 1994, 149, 385-386... 

Antirheumatic, Immunomodulatory. Created using phage display technology. Has human-derived heavy- and light-chain variable regions and human constant regions. It is produced by recombinant DNA technology in a mammalian cell expression system. 

Immunomodulatory, Immunosupressant. Blocks IL-2R alpha on surface of activated T lymphocytes. Produced by mouse myeloma cell line. Contains human heavy- and light-chain constant regions and murine heavy- and light-chain variable regions. 

Light-chain variable region determinants for immunoglobulin k chains are among the most precisely localized antigenic determinants, in large measure because of the work of Solomon and his associates. 

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