Immunoglobulin variable regions

Abbreviations MBN, myoglobin MGN, myogen MHN, myohemerythrin RUB, mbredoxin ICG, immunoglobulin constant region IGV, immunoglobulin variable region PBN, prealbumin SDM, superoxide dismutase CON, conconavalin A CHT, chymotrypsin INS, insulin PTI, pancreatic trypsin inhibitor CB5, cytochrome b5 ... 

Bentley, D.L. Rabbitts, T.H. (1980). Human immunoglobulin variable region genes—DNA sequences of two VK genes and a pseudogene. Nature 288,730-733. 

Seidman, J.G., Leder, A., Edgell, M.H., Polsky, F., Tilghman, S.M., Tiemeier, D.C., Leder, P. (1978). Multiple related immunoglobulin variable-region genes identified by cloning and sequence analyis. Proc. Natl. Acad. Sci. USA 75,3881-3885. 

Tonegawa, S., Brack, C., Hozumi, N., Schuller, R. (1977c). Cloning of an immunoglobulin variable region gene from mouse embryo. Proc. Natl. Acad. Sci. USA 74, 3518-3522. 

Zeelon, E.P., Bothwell, A.L.M., Rantor, F., Schechter, 1. (1981). An experimental approach to enumerate the genes coding for immunoglobulin variable-regions. Nucleic Acids Res. 9, 3809-3820. 

W11. Winkler, T. H., Fehr, H., and Kalden, J. R., Analysis of immunoglobulin variable region genes from human IgG anti-DNA hybridomas. Eur. J. Immunol. 22,1719-1728 (1992). 

H3. Hamblin, T. J., Orchard, J. A., Ibbotson, R. E., Davis, Z., Thomas, R W., Stevenson, F. K., and Oscier, D. G., CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease. Blood 99, 1023-1029 (2002). 

Wang, X. Stollar, B. D., Human immunoglobulin variable region gene analysis by single cell RT-PCR, J. Immunol. Methods 2000, 244, 217-225... 

Raphson minimizer vas used. A variation of this procedure has been used with success by Snov and Amzel (1986) to model immunoglobulin variable regions. 

Immunoglobulin variable region genes are extraordinarily polymorphic, displaying a degree of genetic diversity paralleling that of the major histocompatibility com-... 

M Welschof, P Temess, F Kolbinger, et al. Amino acid sequence based PCR primers for amplification of rearranged human heavy and light chain immunoglobulin variable region genes. J Immunol Meth 179 203-214, 1995. 

Kelley, D., Coleclough, C., and Perry, R. P, 1982, Functional significance and evolutionary development of the 5 -terminal regions of immunoglobulin variable-region genes. Cell 29 681. 

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