Redox-regulation

Jana A, Pahan K (2004) Human immunodeficiency virus type 1 gpl20 induces apoptosis in human primary neurons through redox-regulated activation of neutral sphingomyehnase. J Neurosci 24 9531-9540... 

Trachootham, D, W Lu, MA Ogasawara, N Rivera-Del Valle, and P Huang. 2008. Redox regulation of cell survival. Antioxid Redox Signal 10(8) 1342-1374. 

Palozza, R, Serini, S., Verdecchia, S. et al. 2007b. Redox regulation of 7-ketocholesterol-induced apoptosis by beta-carotene in human macrophages. Free Radio Biol Med 42 1579-1590. 

S. Taoka, S. Ohja, X. Shan, W. D. Kruger, and R. Banerjee, Evidence for heme-mediated redox regulation of human cystathionine beta-synthase activity. J. Biol. Chem. 273, 25179-25184 (1998). 

In 1986, the antioxidant effects of thioredoxin reductase were studied by Schallreuter et al. [81]. It has been shown that thioredoxin reductase was contained in the plasma membrane surface of human keratinocytes where it provided skin protection against free radical mediated damage. Later on, the reductive activity of Trx/thioredoxin reductase system has been shown for the reduction of ascorbyl radical to ascorbate [82], the redox regulation of NFkB factor [83], and in the regulation of nitric oxide-nitric oxide synthase activities [84,85],... 

Kamata, H. and Hirata, H., Redox regulation of cellular signalling, Cell. Signal., 11, L 1999. 

Nikitovic, D., Holmgren, A., S-Nitrosoglutathione is cleaved by the thioredoxin system with liberation of glutathione and redox regulating nitric oxide,/. Biol. Chem. 27 (1996),... 

Biesalski, FI. K., and Frank, J. (2002). Antioxidants in cancer therapy Is there a rationale to recommend antioxidants during cancer therapy In "Thiol Metabolism and Redox Regulation of Cellular Functions" (A. Pompella, G. Banhegyi, and M. Wellman-Rousseau, eds.), NATO Science Series, Series I Life and Behavioural Sciences. Vol. 347, pp. 252-264. lOS Press, The Netherlands. 

NBT, 3,3 -(3,3 -dimethoxy-l,l -biphenyl-4,4 -diyl)bis 2-(4-nitrophenyl)-5-phenyl-2H-tetrazolium dichloride, nitroblue tetrazolium NDGA, nordihydroguaiaretic acid NF- , redox-regulated transcription factor NHA, iM -hydroxy-L-arginine... 

Dietz, K.J., Link, G., I istorius, E.K., Scheibe, R. (2002) Redox regulation in oxygenic photosynthesis. Prog. Botany 63, 207-245. 

Calabrese V, Guagliano E, Sapienza M, Panebianco M, Calafato S, Puleo E, Pennisi G, Mancuso C, Butterfield DA, Stella AG. 2007a. Redox regulation of cellular stress response in aging and neurodegenerative disorders Role of vitagenes. Neurochem Res 32 757-773. 

Dalle-Donne I, Rossi R, Giustarini D, Colombo R, Milzani A. 2007. S-glutathionyla-tion in protein redox regulation. Free Radic Biol Med 43 883-898. 

Ghezzi P, Bonetto V, Fratelli M. 2005. Thiol-disulfide balance From the concept of oxidative stress to that of redox regulation. Antioxid Redox Signal 7 964-972. 

Giustarini D, Rossi R, Milzani A, Colombo R, Dalle-Donne 1.2004. S-glutathionylation From redox regulation of protein functions to human diseases. J Cell Mol Med 8 201-212. 

Klatt P, Molina EP, De Lacoba MG, Padilla CA, Martinez-Galesteo E, Barcena JA, Lamas S. 1999. Redox regulation of c-Jun DNA binding by reversible S-glutathiolation. FASEB J 13 1481-1490. 

Sparaco M, Gaeta LM, Tozzi G, Bertini E, Pastore A, Simonati A, Santorelli FM, Piemonte F. 2006. Protein glutathionylation in human central nervous system Potential role in redox regulation of neuronal defense against free radicals. J Neurosci Res 83 256-263. 

Fig. 7.4 Reactions associated with the thioredoxin system. Thioredoxin is a redox-regulating protein with a redox-active disulfide/dithiol within the conserved active site sequence -Cys-Gly-pro-Cys-. Thioredoxin reductase, a 55 kDa flavoprotein that catalyzes the NADPH-dependent reduction of thioredoxin (1) and thioredoxin oxidase (2), a flavin-dependent sulfhydry 1 oxidase that catalyzes the oxidative protein folding with the generation of disulfides...

Tanaka, T., Akatsuka, S., Ozeki, M., Shirase, T., Hiai, H., and S. Toyokuni, 2004, Redox regulation of annexin 2 and its implications for oxidative stress-induced renal carcinogenesis and metastasis. Oncogene. 13 23(22) 3980-9. 

Wasylyk, C. and Wasylyk, B. 1993. Oncogene conversion of Ets affects redox regulation in vivo and in vitro. Nucleic Acid Res. 21, 523-529. 

Salmeen, A., J.N. Andersen, M.P. Myers, T.C. Meng, J.A. Hinks, N.K. Tonks, and D. Barford. 2003. Redox regulation of protein tyrosine phosphatase IB involves a sulphenyl-amide intermediate. Nature. 423 769-73. 

Rusnak, F. and T. Reiter. 2000. Sensing electrons Protein phosphatase redox regulation. Tr. Biochem. Sci. 25 527-9. 

A cellular redox regulator, glutathione, which undergoes NADP(H)-linked interconversion between the oxidized and reduced forms, also interconverts with its constituent amino acids (Glu, Gly, and Cys). Construct (search metabolic databases) the annotated glutathione metabolic cycle including its redox and anabolic/catabolic interconversions. 

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