Redox- or Oxygen-Dependent Regulation of the EPO Gene

In conclusion, EPO expression is induced by hypoxia via activation of HIF-1. The P02-dependent modulation of ROS levels within the physiological range of PO2 values can modulate EPO gene expression. HIF-1 regulation, however, depends on oxygen-sensitive hydroxylation of prohne residues of HIF-la by prolyl hydroxylases 

Marcel Dekker, Inc. 270 Madison Avenue. New York. New Yoik 10016 

I gratefully acknowledge the continuous support and fiiendship of Helmut Acker, Frank Bunn, and Wolfgang Jelkmann, as well as my co-workers Stilla Frede, Patricia Freitag, Just Genius, and Horst Pagel. 

Jelkmatm W. Erythropoietin structure, control of production, and function. Physiol Rev 1992 72(2) 449-489. 

Jacohson LO, Goldwasser E, Fried W, Plzak L. Role of the kidney in erythropoiesis. Nature 1957 179 633-634. 

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