Transient receptor potential

These are a subset of sensory neurons having their cell bodies (small to medium size) in dorsal root and in cranial nerve ganglia and possessing nonmyelinated (C-type) or thinly myelinated (A-delta type) fibres. This subset of neurons express transient receptor potential vanilloid type 1 (TRPV1, or vanilloid, or capsaicin receptor) that is excited by capsaicin, the pungent ingredient of chilli. These neurons have been classified as polymodal nociceptors because they can be excited by various noxious stimuli. 

The founding member of the TRP channel family, TRP, was identified as the product of a gene locus, which was referred to a transient receptor potential (TRP), because TRP mutant flies display a defect in light induced Ca2+ influx. 

A superfamily of cation channels conserved in mammals, flies, worms and yeast. The various TRP-proteins bear-sequence and predicted structural similarities to the founding member of this superfamily, transient receptor-potential (TRP), a light activated cation channel in the Dmsophila photoreceptor. 

Transgenic Animal Models Transient Receptor Potential Transition State Translation Inhibitors Translocon... 

The Transient Receptor Potential Vanilloid 1 (TRPVl) (vanilloid receptor 1)... 

The intracellular processes which precede membrane activation appear to differ from those of MOE neurones, in that cyclic nucleotide gating may not occur. The transduction process which induces current flow in snake VN neurones, utilises as a putative second-messenger the modulator compound inositol triphosphate — Ins. (1,4,5) P3 = IP3 (Liu et al, 1999 Taniguichi et al, 2000). The proposed channel component associated with the microvillous membrane is one of the transient receptor potential family (TRPC-2 Heading Fig., pp. 94), the p-splice... 

Hofmann T., Schaefer M., Schultz G. and Gudermann T. (2000a). Transient receptor potential channels as molecular substrates of receptor-mediated cation entry. J Mol Med 78, 14-25. 

Perez, C. A. et al. A transient receptor potential channel expressed in taste receptor cells. Nat. Neurosci. 5 1169-1176, 2002. 

Is this system relevant for hair cells It does not appear so. Indeed, there appear to be at least two broad classes of mechanoreceptors, one like those of C. elegans touch neurons that rely on DEG/ENaC channels, and another class that apparently relies on transient receptor potential (TRP) channels. As we will see later, circumstantial evidence suggests that hair cells use TRP channels. Other mechanoreceptors in vertebrates may be related to C. elegans touch cells. 

The molecules that transduce noxious heat or cold are members of the transient receptor potential (TRP) receptor family 929 Receptors that transduce mechanical stimuli are members of the Degenerin family 930... 

The molecules that transduce noxious heat or cold are members of the transient receptor potential (TRP) receptor family. TRP proteins (Table 57-2) form tetra-meric nonselective cation channels within the plasma membrane, allowing sodium and calcium ion influx [4]. The TRPV3 channel is activated at temperatures between 31 and39°C, TRPV1 at43°C, and TRPV2 at 52-55°C. The heat pain threshold in humans is 43°C, suggesting that... 

Clapham, D. E., Montell, C., Schultz, G. and Julius, D. International Union of Pharmacology. XLIII. Compendium of voltage-gated ion channels transient receptor potential channels. Pharmacol. Rev. 55 591-596,2003. 

The molecular entities of VOCCs have been well characterized. Ten distinct genes have so far been cloned, six of which have been identified in smooth muscle (Hofmann et al 1999, Ertel et al 2000). In contrast, the molecular counterparts of ROCCs and CCE have long been elusive, due probably to the lack of specific ligands/blockers and the presence of complex entangled regulatory mechanisms. The transient receptor potential (TRP) protein gene... 

Helliwell RM, Large WA 1997 Alphal-adrenoceptor activation of a non-selective cation current in rabbit portal vein by 1,2-diacyl-sn-glycerol. J Physiol 499 417-428 Hofmann F, Lacinova L, Klugbauer N 1999 Voltage-dependent calcium channels from structure to function. Rev Physiol Biochem Pharmacol 139 33—87 Hofmann T, Schaefer M, Schultz G, Gundermann T 2000 Transient receptor potential channels as molecular substrates of receptor-mediated cation entry. J Mol Med 78 14—25 Inoue R, Okada T, Onoue H et al 2001 The transient receptor potential protein homologue TRP6 is the essential component of vascular aj-adrenoceptor-activated Ca2+-permeable cation channel. Circ Res 88 325—332... 

Okada T, Inoue R, Yamazaki K et al 1999 Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca2+-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor. J Biol Chem 274 27359-27370... 

Welsh DG, Morielli AD, Nelson MT, Brayden JE 2002 Transient receptor potential channels regulate myogenic tone of resistance arteries. Circ Res 90 248-250 Xu SZ, Beech DJ 2001 TrpCl is a membrane-spanning subunit of store-operated Ca2+ channels in native vascular smooth muscle cells. Circ Res 88 84-87 Yamazawa T, lino M, Endo M 1992 Presence of functionally different compartments of the Ca2+ store in single intestinal smooth muscle cells. FEBS Lett 301 181—184... 

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