Early receptor potential

The chronological order of the oscillations that appear following a light flash are the Early Receptor Potential (ERP), the negative a-wave, the positive b-wave, and the positive... 

Cone RA. Early receptor potential of the vertebrate retina. Nature 1964 201 626-628. 

Dawson W, Galloway N. Early receptor potential origin and clinical applications. In Heckenliveley J, Arden G, eds. Principles and Practice of Clinical Electrophysiolology of Vision. Mosby Year Book. St. Louis, MO, 1991. 

Hong F T 1978 Mechanisms of generation of the early receptor potential revisited... 

Seki A, Kubo I, Sasabe H and Tomioka H 1994 A new anion-sensitive biosensor using an ion-sensitive field effect transistor and a light-driven chloride pump, halorhodopsin Appl. Biochem. Biotechnol. 48 205-11 Fuller B E, Okajima T L and Hong F T 1995 Analysis of the d.c. photoelectric signal from model bacteriorhodopsin membranes d.c. photoconductivity determination by means of the null current method and the effect of proton ionophores Bioelectrochem. Bioenerget. 37 109-24 Cone R A 1967 Early receptor potential photoreversible charge displacement in rhodopsin Science 155 1128-31... 

The stimulation of a visual receptor in a vertebrate eye by an intense flash of light generates a fast electrical response, the early receptor potential (RP). A similar response in the pigment epitheUum-choroid complex (PE-CC) of the eye was observed by Brown (26) which unlike the early RP is photostable and resistant to light adaptation. The PE-CC consists of the cell layers immediately behind the retina which are densely pigmented with melanin. Brown concluded that the photopigment involved in the PE-CC response was related to the visual pigments. 

Sieving, P.A., Fishman, G.A., and Maggiano, J.M. 1978. Corneal wick electrode for recording bright flash electroretinograms and early receptor potentials. Arch. Qphthal. 96 899-900. 

There is another way to potentiaUy foUow proton kinetics in intact ROS and that is to use the early receptor potential (ERP) or the early receptor current (ERG). The ERP is a very fast potential/current evoked from oriented photoreceptors with bright flashes (reviewed in Cone and Pak and Sullivan and Shukla ). At room temperature, two phases can be easily observed for the ERP, a somewhat faster (sub msec) corneal negative R1 and a bit slower (1 to 10 msec) potential of opposite sign, R2. For rhodopsin, Cone showed that the kinetics of appearance of R2 and Meta II were identical within experimental error (this correlation was also reported by Spalink and Stieve " for bovine retinas at 37°C). This finding, along with R2 s temperature dependence, led Cone to propose that R2 was due to charge movements associated with the Meta-I-to-Meta-II transition. (R1 was similarly linked to the RH to Meta I transitions.)... 

Cone, R.A., Early receptor potential photoreversible charge displacement in rhodopsin. Science, 155, 1128,1967. 

Cone, R.A., The early receptor potential, in Proceedings of the International School of Physics Enrico Fermi", Reichardt, W., Ed., Academic Press, New York, 1969, p. 187. 

Spalink, J.D. and Stieve, H., Direct correlation between the R2 component of the early receptor potential and the formation of metarhodopsin 11 in the excised bovine retina, Biophys. Struct. Meek, 6,171, 1980. 

The Early Receptor Potential and its Analog in Bacteriorhodopsin Membranes... 

FIGURE 128.1 The early receptor potential from the retina of a Cynmolgus monkey (A and B) and from an albino rat (C, D, and E). In Records A and B, the stimulus was a 20-ps flash, and the ERP appears without an appreciable delay after the light stimulus and merges into the ERG o-wave (also known as the late receptor potential). The late receptor potential can be abolished by anoxia, leaving the ERP intact, as shown by the dotted line in Record A. Records C, D, and E show the ERP at 35,25, and 0°C, respectively. [From Brown, K.T., Watanabe, K., and Murakami, M., Cold Spring Harbor Symp. Quant. Biol., 30, 457, 1965 (A and B) Pak, W.L. and Cone, R.A., Nature, 204, 836, 1964 (C,D,E). With permission.]... 

Brown, K.T., Watanabe, K., and Murakami, M., The early receptor potentials of monkey cones and rods. Cold Spring Harbor Symp. Quant. Biol, 30,457,1965. 

Hodgkin, A.L. and O Bryan, P.M., Internal recordings of the early receptor potential in turtle cones,... 

Trissl, H.-W, On the rise time of the Rl-component of the early receptor potential, Biophys. Struct. 

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