Cyclic nucleotide-gated

Kaupp UB, Seifert R (2002) Cyclic nucleotide-gated ion channels. Physiol Rev 82 769-824... 

Adenylyl Cyclases Guanylyl Cyclases Transmembrane Signalling Cyclic Adenosine Monophosphate Cyclic Guanosine Monophosphate Cyclic Nucleotide-gated Channels Phosphodiesterases... 

Hypeipolarisation-activated and cyclic nucleotide-gated-channel. 

Hyperpolarization-activated and Cyclic Nucleotide-gated Channels (HCN)... 

The intracellular processes which precede membrane activation appear to differ from those of MOE neurones, in that cyclic nucleotide gating may not occur. The transduction process which induces current flow in snake VN neurones, utilises as a putative second-messenger the modulator compound inositol triphosphate — Ins. (1,4,5) P3 = IP3 (Liu et al, 1999 Taniguichi et al, 2000). The proposed channel component associated with the microvillous membrane is one of the transient receptor potential family (TRPC-2 Heading Fig., pp. 94), the p-splice... 

Cyclic nucleotide-modulated ion channels (Table 6-2) are not K+-selective. Nevertheless, their inward current of Na+ and Ca2+ ions is conducted through a channel that is similar in overall architecture to Shaker K+ channels. This protein family includes the CNG channels, which respond only to cyclic nucleotides, and the HCN channels, which are activated synergistically by hyperpolarization and cyclic nucleotide binding [38,40]. The CNG channels are involved in signaling of visual and olfactory information and serve as cyclic nucleotide-gated Ca2+ channels. In contrast, the HCN channels are required for normal rhythmic electrical discharges by the sinoatrial node in the heart and the pacemaker cells of the thalamus. 

There are important exceptions to the rule that the physiological effects of cAMP in mammals are achieved via the activation of protein kinase A. The most prominent is a class of ion channels, referred to as HCN (hyperpolarization cyclic nucleotide gated) channels, that directly bind, and are thereby gated by, cAMP. Several forms of HCN channel are widely expressed in brain and peripheral tissues and have been implicated in the regulation of many facets of cell function. 

Trudeau, M. C. and Zagotta, W. N. Calcium/calmodulin modulation of olfactory and rod cyclic nucleotide-gated ion channels. /. Biol. Chem. 278 18705-18708, 2003. 

The cyclic-nucleotide-gated channel is permeable to cations, especially Ca2+. Thus, increased channel activation results in influx of Ca2+ and a transient rise in the intracellular Ca2+ concentration. Intracellular Ca2+ concentrations of 1-3 J,M have been found to lead to a decrease in the open probability of the ion channel, even... 

Nakamura, T. and Gold, G. H. A cyclic nucleotide-gated conductance in olfactory receptor cilia. Nature 325 442-444,1987. 

Brunet, L. J., Gold, G. H. and Ngai, J. General anosmia caused by a targeted disruption of the mouse olfactory cyclic nucleotide-gated cation channel. Neuron 17 681-693, 1996. 

CNG cyclic nucleotide-gated channel (i) 2, 3 cyclic nucleotide 3 -phosphodiesterase ES embryonic stem cell... 

Genistein (64), an isoflavone found in plants of the family Legu-minosae, is an inhibitor of several protein tyrosine kinases (PTK) and is currently in phase II clinical trials for its potential as an angiogenesis inhibitor. Genistein also has been utilized as a probe to identify binding sites for PTKs by observing the effect it demonstrates on cyclic-nucleotide-gated channels. ... 

MolokanovaE, Kramer RH, Mechanism of inhibition of cyclic nucleotide-gated channel by protein tyrosine kinase probed with genistein, J Gen Physiol 117 219-234, 2001. 

POMC peptides derived from rat pituitary extracts prolactin-releasing peptides in the bovine hypothalamic extract pseudechetoxin, a peptide blocker of cyclic nucleotide-gated ion channels pseudo-peptide analogues of thiol proteinase inhibitors relaxin-like molecule from the male atlantic stingray, Dasyatis sabina... 

Perception of bitter taste can take place via G-proteins the a-subrmit of these G-proteins is know as gustducin and is highly homologous with transducin. The corresponding receptors are just beginning to be characterized (Hohn, 1999). A phosphodiesterase with specificity for cyclic nucleotides and a cyclic nucleotide-gated ion charmel... 

Yau, K.W. Cyclic nucleotide-gated channels an expanding new family of ion channels (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 3481-3483... 

Barco A, Alarcon JM, Kandel ER (2002) Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture. Cell 108 689-703 Bear MF, Malenka RC (1994) Synaptic plasticity LTP and LTD. Curr Opin Neurobiol 4 389-99 Bender RA, Brewster A, Santoro B, Ludwig A, Hofmann F, Biel M, Baram TZ (2001) Differential and age-dependent expression of hyperpolarization-activated, cyclic nucleotide-gated cation channel isoforms 1 1 suggests evolving roles in the developing rat hippocampus. Neuroscience 106 689-98... 

Biel M, Zong X, Ludwig A, Sautter A, Hofmann F (1999) Structure and function of cyclic nucleotide-gated channels. Rev Physiol Biochem Pharmacol 135 151-71 Blackshaw S, Eliasson MJ, Sawa A, Watkins CC, Krug D, Gupta A, Arai T, et al. (2003) Species, strain and developmental variations in hippocampal neuronal and endothelial nitric oxide synthase clarify discrepancies in nitric oxide-dependent synaptic plasticity. Neuroscience 119 979-90... 

Brenman JE, Chao DS, Gee SH, McGee AW, Craven SE, Santillano DR, Wu Z, et al. (1996) Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha 1-syntrophin mediated by PDZ domains. Cell 84 757-67 Broillet MC, Firestein S (1996) Direct activation of the olfactory cyclic nucleotide-gated channel through modification of sulfhydryl groups by NO compounds. Neuron 16 377-85... 

Broillet MC, Firestein S (1997) Beta subunits of the olfactory cyclic nucleotide-gated channel form a nitric oxide activated Ca2+ channel. Neuron 18 951-8 Bugnon O, Schaad NC, Schorderet M (1994) Nitric oxide modulates endogenous dopamine release in bovine retina. Neuroreport 5 401—4... 

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