Transient receptor potential melastatin

Johnson CD, Melanaphy D, Purse A, Stokesberry SA, Dickson P, Zholos AV (2009) Transient receptor potential melastatin 8 channel involvement in the regulation of vascular tone. Am J Physiol Heart Circ Physiol 296 1868... 

Zholos A (2010) Pharmacology of transient receptor potential melastatin channels in the vasculature. Br J Pharmacol 159 1559... 

Thebault S, Lemonnier L, Bidaux G, Flourakis M, Bavencoffe A, Gordienko D, Roudbaraki M, Delcourt P, Panchin Y, Shuba Y, Skryma R, Prevarskaya N (2005) Novel role of cold/menthol-sensitive transient receptor potential melastatine family member 8 (TRPM8) in the activation of store-operated channels in LNCaP human prostate cancer epithelial cells. J Biol Chem 280 39423... 

Uptake of low micromolar Cd concentrations into human osteoblast-like MG-63 cells [299] and mouse MC3T3-E1 cells [300] has been recently demonstrated. The studies suggested that uptake of Cd and cytotoxicity are mediated by transient receptor potential melastatin-related 7 (TRPM7) charmels though the permeability of TRPM7 to Cd is weak [301]. The authors also proposed that deficiency of Ca " or Mg ", which are preferentially transported by TRPM7 [301], may enhance Cd uptake into osteoblast cells. 

Members of a novel series of benzothiophene derived phosphonate esters (456)-(458) have been shown to be potent antagonists of the transient receptor potential melastatin 8 (TRPM8) channel. Structure-activity relationships were developed by modification of the core structure and subsequently by variation of the aromatic substituents and the... 

TRP —transient receptor potential channel TRPA—TRP ankyrin receptor subfamily TRPC—TRP canonical receptor subfamily TRPM—TRP melastatin receptor subfamily TRPML—TRP mucolipin receptor subfamily TRPN—TRP NOMPG receptor family TRPP—TRP polycystin receptor subfamily TRPV—TRP vanilloid receptor subfamily TTX—tetrodotoxin... 

Transient receptor potential (TRP) channels play an important role in a diversity of sensory function, including taste, smell, hearing and perception of pain. This family comprises proteins with six transmembrane-spanning domains that are assembled either as homotetramers or heterotetramers to form non-selective cation channels permeable to calcium and sodium ions. There are at least six subfamilies, including TRPC (canonical), TRPM (melastatin), TRPV (vanilloid), TRPA (ankyrin), TRPML (mucolipin) and TRPP (polycystin) (Nilius et al. 2007). 

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