Receptor comparative distribution

Mitchell, V., Bouret, S., Beauvillain, J. C. et al. (2001). Comparative distribution of mRNA encoding the growth hormone secretagogue-receptor (GHS-R) in Microcebus murinus (Primate, lemurian) and rat forebrain and pituitary. J. Comp. Neurol. 429, 469-89. 

Hirst WD, Abrahamsen B, Blaney FE, et al. Differences in the central nervous system distribution and pharmacology of the mouse 5-hydroxytryptamine-6 receptor compared with rat and human receptors investigated by radioligand binding, site-directed mutagenesis, and molecular modeling. Mol Pharmacol 2003 64 1295-1308. 

Piggott M, Owens J, O Brian J, Paling S, Wyper D, et al. 2002. Comparative distribution of binding of the muscarinic receptor ligands pirenzepine, AF-DX 384, (R,R)-I-QNB and (R,S)-I-QNB to human brain. J Chem Neuroanat 24 ... 

Tribollet E, Bertrand D, Marquerat A, Raggenbass M. 2004. Comparative distribution of nicotinic receptor subtypes during development, adulthood and aging An autoradiographic study in the rat brain. Neuroscience 124 405-420. 

Richfield EK, Young AB, Penney JB (1987) Comparative distribution of dopamine D-l and D-2 receptors in the basal ganglia of turtles, pigeons, rats, cats, and monkeys. J Comp Neurol 262 446-463. 

Shughrue, P. J., Lane, M. V., Scrimo, P. J., and Merchenthaler, I., Comparative distribution of estrogen receptor-alpha (ER-alpha) and beta (ER-beta) mRNA in the rat pituitary, gonad, and reproductive tract. Steroids 63, 498-504 (1998). 

The levels of these receptors are substantially higher than those seen in the adult rat brain (Berrendero et al. 1999). Moreover, in the fetal and early neonatal brain, there is an atypical distribution of CBi receptors compared to the adult brain, particularly with regard to the location of receptor binding in white matter areas (Romero et al. 1997) and mRNA expression in subventricular zones of the forebrain (Berrendero et al. 1998,1999), areas in which these receptors are scarce or undetectable in the adult brain (Herkenham et al. 1991 Mailleux and Vanderhaeghen 1992b). This atypical location of CBi receptors is a transient phenomenon, since during the course of late postnatal development these receptors progressively acquire the classic pattern of distribution observed in the adult brain (Romero et al. 1997 Berrendero et al. 1998). 

Saucedo-Cardenas, O. and Conneely, O.M. (1996) Comparative distribution of NURR1 and NUR77 nuclear receptors in the mouse central nervous system. Journal of Molecular Neuroscience, 7, 51-63. 

Figure 4 Photomicrographs of the comparative distribution of [l25I] [Leu31,Pro34]PYY binding sites and Y1 receptor mRNA in at the level of the frontal cortex of the human brain. Adjacent coronal sections were incubated with either 35 pM [12>I] [Leu31,Pro34]PYY in the presence or absence of 1 pM pNPY and 35S-sense and 35S-antisense of the NPY Y1 receptor mRNA. See list of abbreviations for details of anatomical identification.

With respect to tissue distribution, the available data is limited to mRNA transcripts which, for all TAARs studied so far, are present at generally low levels when compared to e.g., 5-HT and DA receptors. The most... 

Legislation enacted by both Canada and the United States (see the US-Canada Air Quality Accord, 1991) will, when implemented, reduce the North American emissions of sulphur dioxide by about 50% based upon the 1980 baseline. These projected emission fields have been appplied in the atmospheric source-receptor models that were described above, to provide a projected deposition field for acidic sulphate that would be expected (14). The predicted sulphate deposition fields have then subsequently been appUed in aquatic effects models that provide estimates of regional surface water acidification distributions (50). The regional acidification profiles have then been used in a model of fish species richness (51) that results in an estimate of the expected presence of fish species as compared to that expected in an unacidified case. 

The question whether PCP and sigma opioids bind to more than one receptor was studied by comparing the binding and regional distribution of binding sites labeled by 3H-PCP, 3H-TCP, 3H-dexoxadrol, ... 

Compared to a,-receptors, a2-receptors have only moderate distribution on the effector tissues however, they have important presynaptic effects. Alpha-one receptors are found on effector tissue cells at the neuroeffector junction the a2-receptors are found on the varicosities of the postganglionic neuron. Norepinephrine released from this neuron not only binds to the a.j-receptors on the effector tissue to cause some physiological effect but also binds to the a2-receptors on the neuron. Alpha-two receptor stimulation results in presynaptic inhibition" or in a decrease in the release of norepinephrine. In this way, norepinephrine inhibits its own release from the sympathetic postganglionic neuron and controls its own activity. Both ar and a2-receptors have equal affinity for norepinephrine released directly from sympathetic neurons as well as circulating epinephrine released from the adrenal medulla. 

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