Rat brain protein kinase

Sekiguchi K, Tsukuda M, OgitaK, KikkawaU, Nishizuka Y. 3 Distinct Forms of rat-brain protein-kinase-C—differential response to unsaturated fatty-acids. Biochem Biophysl Res Commun 1987 145 797-802. 

Kitano T, Hashimoto T, Kikkawa U, Ase K, Saito N, Tanaka C, Ichimori Y, Tsukamoto K, Nishizuka Y (1987) Monoclonal antibodies against rat brain protein kinase C and their application to immunocyto-chemistry in nervous tissues. J. Neurosci., 7, 1520-1525. 

Fig. 5. Phosphorylation of poly(ADP-ribose) synthetase by purified rat brain protein kinase C. Enzyme reaction was performed principally as described by Kikkawa et al. (20) with l-oleoyl-2-acetyl-rac-glycerol (OAG) and phosphatidyl serine as activator. A The reaction was carried out with (O ) or without ( ) C-kinase activator (Ca /OAG/phosphatidyl-serine) the indicated concentration of poly(ADP-ribose) s mthetase was added to the reaction nuxture in place of phosphate-accepting protein. B Time course of the reaction.

O Brian CA, Ward NE, Weinstein IB, Bull AW, Marnett LJ. Activation of rat brain protein kinase C by lipid oxidation products. Biochem Biophys Res Commun 1988 155 1374-1380. 

Militante JD, Lombardini JB (1999) Taurine uptake activity in the rat retina protein kinase C-independent inhibition by chelerythrine. Brain Res 818 368-374... 

Mani, J., N. Chaudhary, M. Kanjalkar and P.U. Shah. (1998) Cerebellar ataxia due to lead encephalopathy in an adult. J. Neurol. Neurosuig. Psychiatr. 65 797-798 Markovac, J. and G.W. Goldstein. (1988a) Lead activates protein kinase C in immature rat brain microvessels. Toxicol. Appl. Pharmacol. 96 14-23 Markovac, J. and G.W. Goldstein. (1988b) Picomolar concentrations of lead stimulate brain protein kinase C. Nature 334 71-73 Markowitz, M. (2000) Lead Poisoning. Pediatr. Rev. 21 327-35... 

Akiyama, K., Suemaru, J. Effect of acute and chronic administration of methamphetamine on calcium-calmodulin dependent protein kinase II activity in the rat brain. Ann. N.Y. Acad. Sci. 914 263, 2000. 

Takaki, M., Ujike, H., Kodama, M. et al. Two kinds of mitogen-activated protein kinase phosphatases, MKP-1 and MKP-3, are differentially activated by acute and chronic methamphetamine treatment in the rat brain. J. Neurochem. 79 679, 2001. 

Nestler E. Under seige the brain and opiates. Neuron 1996 16 897—900. Nestler E, Tallman J. Chronic morphine treatment increases cAMP dependent protein kinase activity in the rat locus coeruleus. Mol Pharmacol 1988 33 127-132. 

Cox, D. A. and Cohen, M. L. 5-HT2B receptor signaling in the rat stomach fundus dependence on calcium influx, calcium release and protein kinase C. Behav. Brain Res. 73 289-292,1996. 

The affect of Li+ on the metabolism of serotonin (5-hydroxytryp-tamine, 5-HT) is equivocal. A number of studies consistently find a Li+-induced increase in the levels of the major metabolite, 5-hydroxyin-doleacetic acid (5-HIAA), in rat brain and in human CSF [155], which appears to reflect an increase in the rate of synthesis of 5-HT [156]. Li+-induced increases in the level of the amino acid precursor, tryptophan, and in the uptake of tryptophan by brain have also been reported [157], implying elevated tryptophan availability during Li+ treatment. In rat brain, chronic Li+ decreases the activity of tryptophan hydroxylase, the enzyme which, when activated by a Ca2+ and calmodulin-dependent protein kinase, leads to the synthesis of 5-HT [158]. Ca2+ increases the strength of binding of tryptophan to the enzyme, whereas Li+ has the opposite effect [159]. Tryptophan uptake is coupled to 5-HT utilization by a negative feedback mechanism and, therefore, the Li+-induced inhibition of tryptophan hydroxylase with a resultant decrease in 5-HT utilization could produce the observed increase in tryptophan uptake. 

G.J. Long, J.F. Rosen, F.A.X. Schanne, Lead activation of protein-kinase-C from rat-brain - determination of free calcium, lead, and zinc by F-19-Nmr, J. Biol. Chem. 269 (1994) 834-837. 

Rubino, T, Vigano, D., Massi, R, Spinello, M., Zagato, E., Giagnoni, G., and Parolaro, D. (2000) Chronic delta-9-tetrahydrocannabinol treatment increases cAMP levels and cAMP-dependent protein kinase activity in some rat brain regions. Neuropharmacology 39 1331-1336. 

McNamara RK, Lenox RH Distribution of protein kinase C substrates MARCKS and MRP in the postnatal developing rat brain. J Comp Neurol 397 337-356, 1998 McNamara RK, Stumpo DJ, Morel LM, et al Effects of reduced myristoylated alanine rich C-kinase substrate expression on spatial learning in mutant mice transgenic rescue and interaction with gene background. Proc Natl Acad Sci U S A95 14517-14522, 1998... 

Nemeroff CB, Krishnan KRR, Reed D, et al Adrenal gland enlargement in major depression a computed tomographic study. Arch Gen Psychiatry 49 384-387, 1992 Nestler EJ, Terwilliger RZ, Duman RS Chronic antidepressant administration alters the subcellular distribution of cyclic AMP-dependent protein kinase in rat frontal cortex. J Neurochem 53 1644-1647, 1989 Nestor PC, Parasuraman R, Haxby JV, et al Divided attention and metabolic brain dysfunction in mild dementia of the Alzheimer s type. Neuropsychologia 29(5) 379-387, 1991... 

Four minor metabolites, psammaplins B-D (503-505) and presammaplin A (506) were isolated from Psammaplysilla purpurea, in addition to psammaplin A (500). Psammaplin B (503) is a thiocyanate bromotyrosine derivative, while psammaplin C (502) is a sulfanamide. Psammaplin D (505) displayed antimicrobial activity and mild tyrosine kinase inhibition [429]. The psammaplins Ai (507) and A2 (508) and aplysinellins A (509) and B (510) were isolated from Aplysinella rhax from both Pohnpei and Palau. These compounds inhibit famesyl protein transferase and leucine aminopeptidase [430]. Another sample of A. rhax from the Great Barrier Reef, Australia contained psammaplin A 11 -sulfate (511) and bisaprasin ll -sulfate (512), both of which inhibited [3H]-l,3-dipropyl-8-cyclopentylxanthine binding to rat brain adenosine Ai receptors [431]. 

Schanen, N.C. Landreth, G. Isolation and characterization of microtubule-associated protein 2 (MAP2) kinase from rat brain. Mol. Brain Res., 14, 43-50 (1992)... 

Takahashi, M. Tomizawa, K. Ishiguro, K. Takamatsu, M. Fujita, S.C. Imahori, K. Involvement of r protein kinase I in paired helical filament-like phosphorylation of the juvenile r in rat brain. J. Neurochem., 64, 1759-1768 (1995)... 

Oliveira JC, Sebastiao AM, Ribeiro JA (1991) Solubilized rat brain adenosine receptors have two high-affinity binding sites for l,3-dipropyl-8-cyclopentylxanthine. J Neurochem 57(4) 1165—1171 Palmer TM, Benovic JL, Stiles GL (1995) Agonist-dependent phosphorylation and desensitization of the rat A3 adenosine receptor. Evidence for a G-protein-coupled receptor kinase-mediated mechanism. J Biol Chem 270(49) 29607-29613... 

Guglielmetti F., Rattray M., Baldessari S., Butelli E., Samanin R., and Bendotti C. (1997). Selective up-regulation of protein kinase C epsilon in granule cells after kainic acid-induced seizures in rat. Brain Res. Mol. Brain Res. 49 188-196. 

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