Randomised Control Trials

Oude Voshaar RC, Gorgels WJ, Mol AJ, et al Tapering off long-term benzodiazepine use with or without group cognitive-behavioural therapy three-condition, randomised controlled trial. Br J Psychiatry 182 498-304, 2003 Parry HJ, Balter MB, Mellinger GD, et al National patterns of psychotherapeutic drug use. Arch Gen Psychiatry 28 18-74, 1973... [Pg.158]

Johnson BA, Ait-Daoud N, Bowden CL, et al Oral topiramate for treatment of alcohol dependence a randomised controlled trial. Lancet 361 (9370) 1677-1685, 2003... [Pg.308]

Barbui C, Hotopf M (2001). Amitriptyline v. the rest still leading the world after 40 years of randomised controlled trials. Br J Psychiatry... [Pg.96]

Randomised controlled trial of streptokinase, aspirin, and combination of both in treatment of acute ischaemic stroke. Multicentre Acute Stroke Trial-Italy (MAST-I)... [Pg.58]

Muir KW, Lees KR, Ford I, Davis S. Magnesium for acute stroke (intravenous magnesium efficacy in stroke trial) randomised controlled trial. Lancet 2004 363 439 45. [Pg.117]

Bath P, Iddenden R, Bath F. Low-molecular-weight heparins and heparinoids in acute ischemic stroke, a meta-analysis of randomised controlled trials. Stroke 2000 31 1770-1778. [Pg.157]

ESPRIT Study Group, Halkes PH, van Gijn J, Kappelle LJ, Koudstaal PJ, Algra A. Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT) randomised controlled trial. Lancet 2006 367(9523) 1665-1673. [Pg.159]

Gabepentin is an antiepileptic drug that has analgesic activity in neuropathic pain states from varying origins. Two recent randomised controlled trials of gabapentin in... [Pg.464]

The a-tocopherol, P-carotene (ATBC) Cancer Prevention study was a randomised-controlled trial that tested the effects of daily doses of either 50 mg (50 lU) vitamin E (all-racemic a-tocopherol acetate), or 20 mg of P-carotene, or both with that of a placebo, in a population of more than 29,000 male smokers for 5-8 years. No reduction in lung cancer or major coronary events was observed with any of the treatments. What was more startling was the unexpected increases in risk of death from lung cancer and ischemic heart disease with P-carotene supplementation (ATBC Cancer Prevention Study Group, 1994). Increases in the risk of both lung cancer and cardiovascular disease mortality were also observed in the P-carotene and Retinol Efficacy Trial (CARET), which tested the effects of combined treatment with 30 mg/d P-carotene and retinyl pahnitate (25,000 lU/d) in 18,000 men and women with a history of cigarette smoking or occupational exposure to asbestos (Hennekens et al, 1996). [Pg.33]

Jadad, A. R. (1998). Randomised Controlled Trials A User s Guide. London BMJ PublishingGroup. Kempermann, G. Kronenberg, G. (2003). Depressed new neurons Adult hippocampal neurogenesis and a cellular plasticity hypothesis of major depression. Biol. Psychiatry, 54(5), 499-503. [Pg.166]

Fergusson, Dean, Steve Doucette, Kathleen Cranley Glass, Stan Shapiro, David Healy, Hebert Paul and Brian Hutton, Association between Suicide Attempts and Selective Serotonin Reuptake Inhibitors Systematic Review of Randomised Controlled Trials , British Medical Journal 330 (2005) 396-99... [Pg.201]

Lawlor, Debbie A. and Stephen W. Hopker, The Effectiveness of Exercise as an Intervention in the Management of Depression Systematic Review and Metaregression Analysis of Randomised Controlled Trials , British Medical Journal 322 (2001) 1-8 Layard, Richard, The Case for Psychological Treatment Centres , British Medical Journal 332 (2006) 1030-32... [Pg.208]

Mittelman MS, Ferris SH, Shulman E, Steinberg G and Levin B (1996). A family intervention to delay nursing home placement of patients with Alzheimer disease A randomised controlled trial. Journal of the American Medical Association, 276, 1725-1731. [Pg.275]

Mantzaris GJ, Archavlis E, Christoforidis P, Kourtessas D, Amberiadis P, Florakis N, Petra-ki K, Spiliadi C, Triantafyllou G A prospective randomised controlled trial of oral ciprofloxacin in acute ulcerative colitis. Am J Gastroenterol 1997 92 454-456. [Pg.102]

Harris ST, Watts NB, Genant HK, McKeever CD, Hangartner T, Keller M, Chesnut III CH, Brown J, Eriksen EF, Hoseyni MS, Axelrod DW, Miller PD for the VERT Study Group (1999) Effects of risedronate treatment on vertebral and non vertebral fractures in women with postmenopausal osteoporosis a randomised controlled trial. J Am Med Assoc 282 1344-1352... [Pg.211]

Wilcock, G.K., et al., "Efficacy and Safety of Galantamine in Patients with Mild to Moderate Alzheimer s Disease Multicentre Randomised Controlled Trial," BMJ, 321,1445-1449 (2000). [Pg.187]

A randomised, controlled trial. Drugs Aging 18(2) 143-149 Roughead EE, Gilbert AL, Primrose JG et al. (1998) Drug-related hospital admissions a review of Australian studies published 1988-1996. Med J Aust 168(8) 405-408 Tinetti ME (2003) Clinical practice. Preventing falls in elderly persons. N Engl J Med 348(1) 42-49... [Pg.10]

Antipsychotics may be widely used in the treatment of elderly people with schizophrenia, however, based on this systematic review, there are little robust data available to guide the clinician with respect to the most appropriate drug to prescribe. Clearly reported large short, medium and long-term randomised controlled trials with participants, interventions and primary outcomes that are familiar to those wishing to help elderly people with schizophrenia are long overdue. [Pg.31]

Mouly S, Salom M, TUlet Y et al. (2007) Management of xerostomia in older patients a randomised controlled trial evaluating the efficacy of a new oral lubricant solution. Dmgs Aging 24(11) 957-965... [Pg.77]

Holland R, Lenaghan E, Harvey I, Smith R, Shepstone L, Lipp A, Christou M, Evans D, Hand C (2005) Does home based medication review keep older people out of hospital The HOMER randomised controlled trial. BMJ 330 293-298... [Pg.126]

Oldfield WL, Larche M, Kay AB Effect of T-cell peptides derived from Eel d 1 on allergic reactions and cytokine production in patients sensitive to cats a randomised controlled trial. Lancet 2002 360 47-53. [Pg.174]

Olin, P., Rasmussen, F., Gustafsson, L., Hallander, H.O., and Heijbel, H. (1997) Randomised controlled trial of two-component, three-component, and five-component acellular pertussis vaccines compared with whole-cell pertussis vaccine. Ad Hoc Group for the Study of Pertussis Vaccines. Lancet. 350, 1569-1577. [Pg.480]

The debate about quality of evidence most frequently ranks large randomised controlled trials as the gold standard, at least for efficacy, with controlled observational studies in the middle, and imcontrolled studies and opinions at the bottom. The evaluation of therapeutic benefit and risk is, in fact, never ending because clinicians will subject marketed medicines to comparison with other existing or new medicines, and they will experiment with alternative dosage schedules and combined use with other treatments. [Pg.201]

Armitage P. Bradford HiU and the randomised controlled trial. Pharm Med 1992 6 23-7. [Pg.236]

Miranda-Filho D, Ximese R, Barone A, et al. Randomised controlled trial of tetanus treatment with antitetanus immunoglobulin by the intrathecal or intramuscular route. Br Med ] 2004 328 615-8. [Pg.308]

SUverstein FE, Faich G, Goldstein, et al. Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis the CLASS study a randomised controlled trial. JAMA 2000 284 1247-55. [Pg.452]

Munro AJ. An overview of randomised controlled trials of adjuvant chemotherapy in head and neck cancer. BrJ Cancer 1995 71 (1 ) 83—91. [Pg.90]

Medical Research Council Advanced Bladder Cancer Working Party. Neoadjuvant cisplatin, methotrexate, and vinblastine chemotherapy for muscle-invasive bladder cancer a randomised controlled trial. Lancet 1999 354 533-540. [Pg.301]

Morrow, A. L., Guerrero, M. L., Shults, J., Calva, J. J., Lutter, C., Bravo, J., Ruiz-Palacios, G., Morrow, R. C., and Butterfoss, F. D. (1999). Efficacy of home-based peer counselling to promote exclusive breastfeeding A randomised controlled trial. Lancet 353,1226-1231. [Pg.77]

The Cochrane Collaboration prepares Cochrane Reviews and aims to update them regularly with the latest scientific evidence. Members of the organisation (mostly volunteers) work together to provide evidence to help people make decisions about health care. Some people read the healthcare literature to find reports of randomised controlled trials others find such reports by searching electronic databases others prepare and update Cochrane Reviews based on the evidence found in these trials others work to improve the methods used in Cochrane Reviews others provide a vitally important consumer perspective and others support the people doing these tasks. The Cochrane Collaboration website provides information on a variety of ways of registering interest or becoming directly involved www.cochrane.org/docs/involve.htm involve. [Pg.23]

Costa J, Borges M, David C, Vaz Carneiro A. Efficacy of lipid lowering dmg treatment for diabetic and nondiabetic patients meta-analysis of randomised controlled trials. BMJ 2006 332 1115-24. [Pg.345]

Coombes RC, Kilburn LS, Snowdon CF, Paridaens R, Coleman RE, Jones SE et al. Survival and safety of exemestane versus tamoxifen after 2-3 years tamoxifen treatment (Intergroup Exemestane Study) a randomised controlled trial. Lancet 2007 369(9561) 559-70. [Pg.463]

Ashcroft DM, Dimmock P, Garside R, Stein K, Williams HC. Efficacy and tolerability of topical pimecrolimns and tacrolimus in the treatment of atopic dermatitis meta-analysis of randomised controlled trials. BMJ 2005 330 516-21. [Pg.470]

In complicated falciparum malaria exchange transfusion can be considered if high parasitemia s (>5%) is present, although the benefit has not been proven with a randomised controlled trial. In these severe cases i.v. quinine (with loading dose) is gradually being replaced by artesunate, wich has proven less mortality and less side effects than good old ... [Pg.541]

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