Rabbit veins

Mann, M.J., Gibbons, G.H., Tsao, P.S., vonderLeyen, H.E., Cooke, J.P., Buitrago, R. etal. (1997) Cell cycle inhibition preserves endothelial function in genetically engineered rabbit vein grafts. J. Clin. Invest., 99, 1295-1301. 

Miyake T, Aoki M et al (2006) Inhibitory effects of NFkappaB decoy oligodeoxynucleotides on neointimal hyperplasia in a rabbit vein graft model. J Mol Cell Cardiol 41(3) 431 140... 

One pyrogen test is a qualitative biological test based on the fever response of rabbits. If a pyrogenic substance is injected into the vein of a rabbit, a temperature elevation will occur within 3 hours. Many imitative medical agents will also cause a fever. 

Later on, the importance of xanthine oxidase as the producer of reoxygenation injury was questioned at least in the cells with low or no xanthine oxidase activity. Thus, it has been shown that human and rabbit hearts, which possess extremely low xanthine oxidase activity, nonetheless, develop myocardial infractions and ischemia-reperfusion injury [9], However, recent studies supported the importance of the xanthine oxidase-catalyzed oxygen radical generation. It has been showed that xanthine oxidase is partly responsible for reoxygenation injury in bovine pulmonary artery endothelial cells [10], human umbilical vein and lymphoblastic leukemia cells [11], and cerebral endothelial cells [12], Zwang et al. [11] concluded that xanthine dehydrogenase may catalyze superoxide formation without conversion to xanthine oxidase using NADH instead of xanthine as a substrate. 

Albert AP, Large WA 2001 Store-operated inward ion channels in rabbit portal vein myocytes. J Physiol 531 80P-81P... 

Helliwell RM, Large WA 1997 Alphal-adrenoceptor activation of a non-selective cation current in rabbit portal vein by 1,2-diacyl-sn-glycerol. J Physiol 499 417-428 Hofmann F, Lacinova L, Klugbauer N 1999 Voltage-dependent calcium channels from structure to function. Rev Physiol Biochem Pharmacol 139 33—87 Hofmann T, Schaefer M, Schultz G, Gundermann T 2000 Transient receptor potential channels as molecular substrates of receptor-mediated cation entry. J Mol Med 78 14—25 Inoue R, Okada T, Onoue H et al 2001 The transient receptor potential protein homologue TRP6 is the essential component of vascular aj-adrenoceptor-activated Ca2+-permeable cation channel. Circ Res 88 325—332... 

Benham CD, Bolton TB 1986 Spontaneous transient outward currents in single visceral and vascular smooth muscle cells of the rabbit. J Physiol 381 385—406 Boittin FX, Coussin F, Macrez N, Mironneau C, Mironneau J 1998 Inositol 1,4,5-trisphosphate-and ryanodine-sensitive Ca2+ release channel-dependent Ca2+ signalling in rat portal vein... 

Wang Q, Hogg RC, Large WA 1992 Properties of spontaneous inward currents recorded in smooth muscle cells isolated from the rabbit portal vein. J Physiol 451 525—537 ZhuGe R, Sims SM, Tuft RA, Fogarty KE, Walsh JV 1998 Ca2+ sparks activate K+ and Cl-channels, resulting in spontaneous transient currents in guinea-pig tracheal myocytes. J Physiol 513 711-718... 

FIG. 5. View of the SR network in a longitudinally oriented rabbit portal vein smooth muscle cell stained with osmium ferricyanide. Note the close apposition of the SR to the plasma membrane (small arrows) and caveolae, as well as its relationship to mitochondria (M) in some instances the SR completely surrounds mitochondria. 

Acute Intravenous Irritation in the Male Rabbit. The design here is similar to the intramuscular assay, except that injections are made into the veins in specific muscle masses. 

Unless otherwise specified in the individual protocol, inject 10 ml of the test solution per kilogram of body weight into an ear vein of each of three rabbits, completing each injection within 10 min after the start of administration. The test solution is either the product, constituted if necessary as directed in the labeling, or the material under test. For pyrogen testing of devices or injection assemblies, use... 

BW-755C and its congeners can be considered as reducing agents either because they are dihydroaromatic compounds, or because of the presence of a hydrazine moiety, which is easily oxidized. In the latter vein, the amid-razone CBS-1114 (100) inhibited platelet CO and 12-LO, the release of 5-LO products from human or rabbit neutrophils (1-10 /M), and leukocyte... 

Invasive continuous hepatic function monitoring by the fluorescence procedure was also evaluated in rabbits [148]. In this study, a commercial catheter equipped with fiber optic technology for mixed venous oxygen saturation measurements (SVO2) was modified to emit light at 780 nm and detect fluorescence at 840 nm. The catheter was placed into the right jugular vein and advanced... 

Rabbit Immunization. Six rabbits were sub-cutaneously injected with. 2 mg of the immunogen in Freund s adjuvent on days 0, 12, 26, 40 and 59 of the immunization schedule (see Table I). Complete adjuvent was used for the first three immunizations followed by incomplete adjuvent for the final two immunizations. The rabbits were bled as needed using ear vein puncture. 

Nagashima, M., Werner, M., Wang, M., Zhao, L., Light, D. R., Pagila, R., Morser, J., Verhallen, P. (2000). An inhibitor of activated thrombin-activatable fibrinolysis inhibitor potentiates tissue-type plasminogen activator-induced thrombolysis in a rabbit jugular vein thrombolysis model. Thromb. Res., 98, 333-342. 

ELBI effect on the morphology of erythrocytes was studied in seven rabbits. ELBI was performed by introducing the waveguide into the lumen of the femoral vein under ether anesthesia. He-Ne laser LG-75 (HNL), Russia, and nitrogen ultraviolet laser LGI-21 (UVL) were used. The power of radiation at the end of waveguide was 2.5 mW, and irradiation was applied for one hour. 

Fig. 30.2 Luminal surface of the rabbit s femoral vein after ELBl with HNL. (a). MicroreUef of the luminal surface of intact vein. (b). Swelling of the supranuclear parts of endotheliocytes after 15 min irradiation, (c). Microrelief of the luminal surface of vein two days after 60 min irradiation...

Two weeks after the second injection, test bleed the rabbit from an ear vein. Swab the ear with xylene to dilate the vein before bleeding. 

The mixture is injected once a week for 3 weeks, and then the animal is maintained for 3 weeks without additional injections. Approximately 25-40 ml of blood is removed from the animal s ear vein to test for antibodies. One week after the first bleed the rabbit is boosted with half the antigen amount used earlier along with incomplete adjuvant incomplete adjuvant does not contain the mycobacteria. Serum is again removed 2 weeks after this injection and tested for antibody response. The enzyme-linked immunosorbent assay is used to determine if the titer (or antibody concentration) of the serum is sufficiently high to establish antibody binding to the antigen. This 3-week cycle is repeated as long as necessary to obtain the antibodies desired. 

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