Quinalbarbitone

Common Name Meballymal sodium quinalbarbitone sodium... 

When quinalbarbitone (secobarbital, 296) was irradiated in acid solution (pH 2) at 254 nm, it underwent photodealkylation to give (297), (298), pent-l-ene and pent-2-ene. These four compounds were also obtained at pH 10, but in addition there were the ring-opened materials (299) to (301), Scheme 2.7 [ 176],... 

Ring dealkylation cinchonidine cinchonine pentobarbitone quinalbarbitone oxytetracycline protriptyline psoralens riboflavin... 

Schedule 2 includes drugs such as dia-morphine (heroin), morphine, pethidine, quin-albarbitone, glutethimide, amphetamine and cocaine and which are subject to the full controlled drug requirements relating to prescriptions, safe custody (except for quinalbarbitone), the need to keep registers, etc. (unless exempted in Schedule 5). 

Schedule 3 includes the barbiturates (except quinalbarbitone, now in Schedule 2), bupren-orphine, diethylproprion, mazindol, meprobamate, pentazocine, phentermine and temazepam. They are subject to the special prescription requirements (except for phenobarbitone and temazepam) but not to the safe custody requirements (except forbuprenorphine, diethyl-propion and temazepam) nor to the need to keep registers (although there are requirements for the retention of invoices for 2 years). 

Smith and Sanagi also studied the SFC of barbiturates (barbitone, butobarbitone, amylobarbitone, pentobarbitone, talbutal, quinalbarbitone, methohexitone, phenobarbitone, and heptabarbitone) using a packed polystyrene-divinylbenzene or octadecylsilane column with a methanol-modi-... 

Methadone Hydrochloride Visual incompatibilities of methadone hydrochloride were observed with solutions of aminophylline, ammonium chloride, amylo-barbitone sodium, chlorothiazide sodium, heparin sodium, nitrofurantoin sodium, novobiocin, pentobarbitone sodium, phenobarbitone sodium, phenytoin sodium, quinalbarbitone sodium, sodium bicarbonate, sodium iodide, sulfadiazine sodium, sulfafurazole diethanolamine, or thiopentone sodium. 

Barbituric acid derivatives account for a high proportion of poisonings, the severity being related to the amount and type of barbiturate ingested. For example, blood concentrations of phenobarbitone or barbitone which do not cause unconsciousness would cause deep coma in the case of pentobarb-itone or quinalbarbitone. 

Amitriptjdine, aniylobarbitone, butobaibdtone, diazepam, imipramine, morphine, orphenadrine, paracetamol, p entobarb-itone, quinalbarbitone, saUcjlates... 

Mobile Phase. Chloroform acetone (4 1). Reference Compounds. Methohexitone Rf 73, quinalbarbitone Rf 55, clonazepam Rf 35,... 

Reference Compounds. Quinalbarbitone Rf 68, salicyl ide Rf 55, ph acetin Rf 38, sulphathia-zoleRf 20. 

Acidified potassium permanganate solution. Yellow-brown spots on a violet badcground are givoi by drugs with unsaturated aliphatic bonds, e.g. quinalbarbitone. This solution may be used to overspray a plate which has been previously sprayed with mercurous nitrate spray. 

Fig. 2. Chromatograms, using FID and AFID in nitrogen mode, of an extract of a blood sample containing barbiturates. The attenuations were adjusted to give approximately equal-sized peaks for the barbiturates on both detectors. The contamination from tri-isobutyl phosphate introduced from the filter paper is apparent. A, tri-isobutyl phosphate B, amylobarbitone C, quinalbarbitone D, C19H40 (retention index marker).

Fig. 10. Combined blood alcohol-barbiturate concentration curves in reported cases of fatal quinalbarbitone poisoning. The various lines connect those concentration pairs which would account for the percentage of cases shown (A. H. Stead and A. C. Moffat, Human Toxicol., 1983,2, 5-14).

In 10 fatalities involving the ingestion of a preparation containing brallobarbitone, quinalbarbitone and hydroxyzine, the following postmortem concentrations, pg/g (mean, n) were reported ... 

In an overdose involving the ingestion of more than 3 g of brallobarbitone (in combination with quinalbarbitone), plasma concentrations of 106 pg/ ml of brallobarbitone and 57 pg/ml of quinalbarbitone were reported 6 hours and 4 hours, respectively, after ingestion the subject slowly recovered after treatment by haemoperfusion (G. de Groot et al.. Vet. Hum. Toxicol., 1979, 21, 8-11). 

Infra-red Spectrum. Principal peaks at wavenumbers 1559,1648, 1690, 1298, 1270, 925 (quinalbarbitone sodium, KBr disk). 

Toxicity. The estimated minimum lethal dose is 2 g. Toxic effects are usually associated with blood concentrations greater than about 8pg/ml. In 276 reported fatalities attributed to quinalbarbitone, blood concentrations ranged from 4 to 132 pg/ ml (mean 30). 

The following postmortem tissue concentrations (pg/ml or pg/g) were reported in 3 fatalities due to quinalbarbitone ... 

Octamylamine Hydrochloride Arecoline Hydrobromide Isosorbide Dinitrate Carbazochrome Carbamazepine Cyclobarbitone Dropropizine Hexobarbitone Methazolamide Procaine Thiacetazone Tetrahydrozoline Hydrochloride Carbromal Cotarnine Viloxazine Ketamine Methyldopa Nitrofurantoin Proxyphylline Nealbarbitone Nomifensine Quinalbarbitone Isoetharine Methyldopate Salbutamol Benzphetamine Methacholine Bromide Danthron Cropropamide Hexethal... 

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