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Ring dealkylation

Ring dealkylation cinchonidine cinchonine pentobarbitone quinalbarbitone oxytetracycline protriptyline psoralens riboflavin... [Pg.115]

Figure 5. LHHW rate equation for irreversible reactions (C-C scission reactions such as parafiBn hydrocracking, opening of naphthene rings, and ring dealkylation). Figure 5. LHHW rate equation for irreversible reactions (C-C scission reactions such as parafiBn hydrocracking, opening of naphthene rings, and ring dealkylation).
Hydrodesulfurization (HDS) reactions proceed via two major pathways/ Direct HDS Figure 5) is relatively simple. However, indirect HDS Figure 6) requires preliminary reactions, such as saturation of aromatics or ring dealkylation. [Pg.185]

Removal of paraffinic side chains (ring dealkylation)... [Pg.189]

C-C scission includes HCR, ring open and ring dealkylation reactions. [Pg.372]

Ring dealkylation reaction 2 Ring open reaction 3 Aromatic satjration 4. Paraffin hydrocracking reaction P paraffins N naphthenes A aromatics AN ring compound which has naphthene and aromatics... [Pg.373]

Figure 6.5 Reaction network of Aspen HYSYS Petroleum Refining HCR paraffin HCR, ring open, ring dealkylation and aromatic saturation. Figure 6.5 Reaction network of Aspen HYSYS Petroleum Refining HCR paraffin HCR, ring open, ring dealkylation and aromatic saturation.
Dichlorotoluene (l,3-dichloro-2-methylben2ene) is prepared from the Sandmeyer reaction on 2-arnino-6-chlorotoluene. Other methods include ring chlorination of -toluenesulfonyl chloride followed by desulfonylation (81), and chlorination and dealkylation of 4-/ f2 -butyltoluene (82) or... [Pg.55]

The acidic character of the hydrogen atoms of C-methyl groups linked to the pyrazolium ring (Figure 22 Section 4.04.2.1.1(11)) facilitates a number of reactions difficult to carry out with neutral pyrazoles. Since efficient methods of dealkylation have been described (Section 4.04.2.3.lO(ii)), the synthesis via the pyrazolium salt is a useful alternative. The same behaviour is observed for indazolium salts, for example, nucleophilic addition to aromatic aldehydes (78JOC1233). [Pg.260]

S-Alkylthiiranium salts, e.g. (46), may be desulfurized by fluoride, chloride, bromide or iodide ions (Scheme 62) (78CC630). With chloride and bromide ion considerable dealkylation of (46) occurs. In salts less hindered than (46) nucleophilic attack on a ring carbon atom is common. When (46) is treated with bromide ion, only an 18% yield of alkene is obtained (compared to 100% with iodide ion), but the yield is quantitative if the methanesulfenyl bromide is removed by reaction with cyclohexene. Iodide ion has been used most generally. Sulfuranes may be intermediates, although in only one case was NMR evidence observed. Theoretical calculations favor a sulfurane structure (e.g. 17) in the gas phase, but polar solvents are likely to favor the thiiranium salt structure. [Pg.154]

It was not their reactivity but their chemical inertness that was the true surprise when diazirines were discovered in 1960. Thus they are in marked contrast to the known linear diazo compounds which are characterized by the multiplicity of their reactions. For example, cycloadditions were never observed with the diazirines. Especially surprising is the inertness of diazirines towards electrophiles. Strong oxidants used in their synthesis like dichromate, bromine, chlorine or hypochlorite are without action on diazirines. Diazirine formation may even proceed by oxidative dealkylation of a diaziridine nitrogen in (186) without destruction of the diazirine ring (75ZOR2221). The diazirine ring is inert towards ozone simple diazirines are decomposed only by more than 80% sulfuric acid (B-67MI50800). [Pg.220]

The composition of the products is reminiscent of the decomposition of the trialkyl-oxaziranes by ferrous salts. Here also the nitrogen atom is dealkylated and the carbon atom of the oxazirane ring is found as a ketone group. [Pg.102]

Fenoldopam (76) is an antihypertensive renal vasodilator apparently operating through the dopamine system. It is conceptually similar to trepipam. Fenoldopam is superior to dopamine itself because of its oral activity and selectivity for dopamine D-1 receptors (D-2 receptors are as.sociated with emesis). It is synthesized by reduction of 3,4-dimethoxyphenylacetonitrile (70) to dimethoxyphenethylamine (71). Attack of diis last on 4-methoxystyrene oxide (72) leads to the product of attack on the epoxide on the less hindered side (73). Ring closure with strong acid leads to substituted benzazepine 74. O-Dealkylation is accomplished with boron tribromide and the catechol moiety is oxidized to the ortho-quinone 75. Treatment with 9NHC1 results in conjugate (1,6) chloride addition and the formation of fenoldopam (76) [20,21]. [Pg.147]

In an attempt to effect a chloroformate-mediated dealkylation of aziridine lactone 119 (Scheme 3.41), Dodd and co-workers observed aziridine ring-opening, a-Chloro lactone 120 was obtained in 72% yield [32]. [Pg.90]

It is also well known that alkyl groups can be tran.sferred intramolecularly from one position to another on the same ring and intermoiccularly from one aromatic ring to another through dealkylation reactions catalyzed by Lewis acid. The intramolecular alkyl-transfer is called reorientation or isomerization and the intermolecular alkyl transfer is referred to as disproportionation. Reorientation processes arc normally faster than disproportionation. [Pg.150]

Atrazine is successively transformed to 2,4,6-trihydroxy-l,3,5-triazine (Pelizzetti et al. 1990) by dealkylation of the alkylamine side chains and hydrolytic displacement of the ring chlorine and amino groups (Figure 1.3). A comparison has been made between direct photolysis and nitrate-mediated hydroxyl radical reactions (Torrents et al. 1997) the rates of the latter were much greater under the conditions of this experiment, and the major difference in the products was the absence of ring hydroxylation with loss of chloride. [Pg.5]

The photolytic degradation of the fluoroquinolone enrofloxacin involves a number of reactions that produce 6-fluoro-7-amino-l-cyclopropylquinolone 2-carboxylic acid that is then degraded to CO2 via reactions involving fission of the benzenoid ring with loss of fluoride, dealkylation, and decarboxylation (Burhenne et al. 1997a,b) (Figure 1.9). [Pg.7]

Combined treatment of atrazine with ozone and H2O2 resulted in retention of the triazine ring, and oxidative dealkylation with or without replacement of the 2-chloro group by hydroxyl (Nelieu et al. 2000). Reaction with ozone and hydroxyl radicals formed the analogous products with the additional formation of the acetamido group from one of the N-alkylated groups (Acero et al. 2000). [Pg.31]

In terms of other sites of metabolism, we are looking at the metabolism in the dioxole ring and in dealkylation. We have seen some interesting things, but I could not comment on this right now. With respect to the alpha-ethyl, I think that the parent compound is probably the one that is active. [Pg.23]

The fate of the dinitroaniline herbicides in soil is extremely complex and many metabolites have been identified. Golab and Althaus reported 28 metabolites identified in a degradation study of trifluralin in soil. Major degradation products of dinitroaniline herbicides were formed by nitro reduction, A-dealkylation (mono-dealkylated and completely dealkylated) and the ring formation of benzimidazole. [Pg.397]


See other pages where Ring dealkylation is mentioned: [Pg.44]    [Pg.44]    [Pg.270]    [Pg.188]    [Pg.189]    [Pg.386]    [Pg.44]    [Pg.44]    [Pg.270]    [Pg.188]    [Pg.189]    [Pg.386]    [Pg.39]    [Pg.343]    [Pg.269]    [Pg.119]    [Pg.102]    [Pg.205]    [Pg.367]    [Pg.96]    [Pg.61]    [Pg.20]    [Pg.88]    [Pg.731]    [Pg.149]    [Pg.152]    [Pg.161]    [Pg.176]    [Pg.577]    [Pg.415]    [Pg.293]    [Pg.102]   
See also in sourсe #XX -- [ Pg.372 ]




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