QA procedures

An outline laboratory QA procedure would need to include the following. In addition to the use of freshly made synthetic calibration standards, in-house standards, internationally recognized reference materials, and method blanks, as described above, it should include ... 

An active program of surveillance of the quality of the immunostains produced must be defined. The primary elements of such a quality assurance (QA) program include procedures and policies for patient test management, quality control, proficiency testing, comparison of test results, relationship of clinical information to patient test results, personnel assessment, communications, complaint investigations, QA review with staff, and QA records. The documentation and review by the laboratory director of all QA procedures is imperative and cannot be overstressed. A brief explanation of each of the QA elements is as follows ... 

For high-throughput purification pipelines, quality assessment (QA) procedures are required which can be carried out in parallel in relatively high throughput. The QA steps routinely carried out in the OPPF are summarized in Table 2.3. Other methods that have been used in HTP projects include one and two-dimensional NMR screening and differential scanning calorimetry. 

Divided into numbered paragraphs or subclauses, includes a preparation-of-test-sample step and reference to QA procedures... 

QA procedures - including auditing procedures and maintaining the master schedule... 

Since the trail-of-evidence was able to be reconstructed so well and the analyst performed his tasks correctly, the value of the data was not lost. However, this circumstance serves as a good model for supporting the necessity of GLP s (which were mostly in place) and QA procedures (which were not followed). 

Maintain QA procedural controls for responsibilities and procedures, and make them... 

Internal QA procedures generally are sufficient in scope to utilize a thorough sampling process to determine internal operations effectiveness in completing corporate objectives, policies and procedures. 

Both barbiturates and benzodiazepines can be identified by using GC-MS methodologies, although each drug class requires a different pre-treatment routine prior to analysis. It should also be remembered, as with all chromatographic analyses, that blanks should be run between each sample nnder investigation and check standards analysed as required by the quality assurance (QA) procedures in place in the laboratory. 

The main reasons for the current lack of comparability at working level include an insufficient awareness of uncertainty and source of error, a lack of high quality reference materials and no recognized system for intercomparison of traceable clinical chemistry measurements. In addition, the limit results were obtained in the absence of a reliable uncertainty budget and insufficient QA procedures. In fact, in the national area the introduction of adequate QA procedures is making its first steps. 

But, as in the safety versus access balancing act there is a delicate juxtaposition of the two methods. In a cost-independent environment, this tension causes no problems if in doubt, simply add additional QCs or more elaborate QA procedures. But in today s cost conscious world the goal is minimally expensive but effective quality safeguards. 

A QA system takes such measures as confirming that designated preparation and QA procedures are being followed by staff at all levels. Such evaluation should be carried out periodically and should result in a written report containing recommendations for action. 

These are some of the same questions that are used to evaluate a standard method (see Sections 11.2.8 and 6.5). Accurate record-keeping in the QAP ensures that standard laboratory procednres are docnmented, and accnrate record-keeping in a laboratory notebook ensnres that a written record exists to indicate that said procedures were indeed followed. Althongh it may seem exaggerated, the importance of instituting QA procedures and keeping QA records cannot be overemphasized. 

Radiation detection instrumentation used in the HCF is calibrated and maintained by representatives of the ES H Center responsible for calibration of radiation protection instrumentation. Calibration due dates are monitored and instrument recall actions are typically initiated prior to expiration of the calibration due date. Instrumentation is replaced in the event of failure or malfunction. Specifics about the procedures used to calibrate instruments, the traceability of calibration standards, and applicable QA procedures are discussed in the ES H Manual Supplement, "Radiological Protection Procedures ManuaP (SNL 1998a). 

The specification should also include agreed acceptance criteria for the data. Unfortunately, disregard of the requirement to discuss and agree on the specification often results in the use of assumed criteria by one or both parties. This may lead to the adoption of methodology, QA procedures, or documentation inappropriate to the purpose for which the data are required. 

In a modern laboratory, even simple QA procedures are an integral part of providing spectroscopic data that are fit for purpose . 

The preponderance of contractual relationships means that the various responsibilities for the final installed quality of a pipe system can sometimes be obscured. Quality is far more easy to assure in the factory situations of polymer and pipe production than it is in the remote and constantly changing situation of site work. Responsibilities for quality can only be assigned by careful contract preparation, cascaded through all stages of the supply chain. Good practice requires the existence of appropriate specifications and standards and the testing and inspection services to implement them. Practical experience dictates that only the acceptance of formalised, strictly applied, QA procedures can ensure that quality standards survive in a cost competitive market. 

Incorporate Quality Assurance (QA) procedures to reconfirm that all breakers are racked-out and "Red Tagged" prior to each plant startup... 

Appropriate QA procedures and programmes are also in place in Czech Republic and Ukraine including data preparation, checking of procedures. Meetings with the Russian design organizations were performed whenever necessary to confirm the validity of data. 

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