Laboratory notebooks

Finally, we cannot end a chapter on the basic tools of analytical chemistry without mentioning the laboratory notebook. Your laboratory notebook is your most important tool when working in the lab, providing a complete record of all your work. If kept properly, you should be able to look back at your laboratory notebook several years from now and reconstruct the experiments on which you worked. 

A useful resource for information on maintaining a useful laboratory notebook is... 

Kanare, H. M. Writing the Laboratory Notebook, American Chemical Society Washington, DC 1985. 

The Laboratory Notebook Page. Most engineers, scientists, and technicians make a record of their work. A common form of record... 

AH of these factors should be considered when evaluating the quaUty of laboratory notebook entries. These entries may otherwise never be considered until they are the subject of a legal contest, at which time quaUty review may be too late. 

Brooks/Cole offers a variety of printed manuals to meet all general chemistry laboratory needs. Visit the chemistry site at academic.cengage.com/chemistry for a full listing and description of these laboratory manuals and laboratory notebooks. All Brooks/Cole lab manuals can be customized for your specific needs. 

Laboratory notebooks—It may be debatable to consider laboratory notebooks as text documents, but they should be mentioned here because of their importance in preclinical development. Laboratory notebooks are used to record experimental procedures, observations, raw data, and other important information. Although laboratory notebooks are rarely used for submission to regulatory agencies directly, they are available for inspection by the authorities in the Preapproval Inspection (PAI) and other GMP/GLP-related inspections. Currently, most of the major pharmaceutical companies still use paper-based laboratory notebooks. Electronic-based notebook systems are being developed and commercialized, which are discussed in Chapter 9. 

There are hidden gold mines under our noses—in house data becomes the new lamps for old on the tons of old clinical data from 50 years of R D— but of course, none of it is electronically accessible. It is called a library Many organizations have undertaken huge OCR (optical character recognition) projects to scan laboratory notebooks—some data even exists on microfilm and microfiche. As it is a legal requirement for a drug submission to provide provenance of scanned notebooks [38], paper, and microfilm, many businesses concentrate solely on the capture and verification of this data, rather than considering it a valuable resource to be remined. 

Within a very short space of time—perhaps only the last 5 years, there has been an explosion of interest in electronic laboratory notebook systems in general, and particularly within the drug discovery community. In large part... 

An electronic laboratory notebook system ( e-notebook or ELN ) addresses several different areas that impact upon scientific productivity, including time efficiencies and communication of information. 

Achour, Z., Laidboeur, T., Gien, O., Musolino, A., Bon, X., Grimaud, B. (2005) Sanofi-Synthelabo Chemical Development and the Development of an Electronic Laboratory Notebook. Organic Process Research Development, 8, 983-997. 

The initial recording of research ideas and data is most always private and takes the form of laboratory notebooks and database files. The first communication of research data and ideas may or may not be private. Oral and informal written communication occurs between research colleagues and teams. In the era of e-mail and listserves, these initial written communications may also be public in that they exist on the Internet. If there is a financial or proprietary interest in the research, the first communication may be in the form of a patent application. 

Newman, William R. and Lawrence M. Principe, eds. Alchemical laboratory notebooks and correspondence edited by William R. Newman and Lawrence M. 

Principe, Lawrence M. and William Royall Newman. "The chymical laboratory notebooks of George Starkey." In Reworking the bench research notebooks in the history of science, eds. Fredrick L. Holmes, Jurgen Renn and Hans-Jorg Rheinburger, 25-41. Dordrecht Kluwer, 2003. 

From the laboratory notebook. Alchem Lab Bulls, no. 13 (Q4 1962). rhttp //www.spagyria.com/alb.zip1. 

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