Pulmonary macrophages

Zelikoff JT, Parsons E, Schlesinger RB. 1993. Inhalation of particulate lead oxide disrupts pulmonary macrophage-mediated functions important for host defense and tumor surveillance in the lung. Environ Res 62 207-222. 

T. Ferkol, F. Mularo, J. Hilliard, S. Lodish, J. C. Perales, A. Ziady, and M. Konstan, Transfer of the human a-antitrypsin gene into pulmonary macrophages in vivo, Am. J. Respir. Cell. Mol. Biol., 18 (1998) 591-601. 

Pulmonary macrophages cultured in vitro for 20 h with media containing 14.5-58.0 mg Ni/kg as nickel chloride Concentration-dependent decrease in viability of alveolar macrophages highest dose had survival of <50%. Death associated with release of superoxide anions 11... 

Waseem, M., R. Bajpai, and J.L. Kaw. 1993. Reaction of pulmonary macrophages exposed to nickel and cadmium in vitro. Jour. Environ. Pathol. Toxicol. Oncol. 12 47-54. 

Upper respiratory irritation, reduced resistance to infection by Salmonella, and increased pulmonary macrophages all effects disappeared by day 63 No adverse effects noted at low concentration. At 3700 pg/L, histopathology of lung, liver, and kidney... 

Respiratory allergies and infections are the most common form of illness in the United States and Europe and account for more missed school and work days than any other disease [1], A substantial body of experimental work has clearly shown that airborne toxicants such as tobacco smoke, ozone, and other air pollutants can alter many aspects of the host defense network to either decrease resistance to infection, or exacerbate respiratory allergies and asthma [2], Exposure to air toxicants can suppress a number of key host defenses including mucociliary clearance in the airways, pulmonary macrophage function, and development of specific immune responses such as IgG antibody production and cell mediated immunity. In contrast, immune stimulation in the form of increased T cell activity and IgE antibody formation has also has been shown to occur under some circumstances, resulting in increased incidence or severity of allergic lung disease. 

Ferin, J. (1977). Effect of particle content of lung on clearance pathways. In Pulmonary Macrophage and Epithelial Cells (Sanders, C.L., Schneider, R.P., Dagle, G.E. and Ragan, H.A., Eds.). Technical Information Center, Energy Research and Development Administration, Springfield, VA, pp. 414-423. 

Kavet, R.I., Brain, J.D. and Levens, D.J. (1978). Characteristics of weekly pulmonary macrophages lavaged from hamsters exposed to iron oxide aerosols. Lab. Invest. 38 312-319. 

Chemical undergoes no significant metabohsm by intestinal microflora or pulmonary macrophages. 

Pulmonary macrophage mobilization in cigarette smoke-exposed mice after halothane anesthesia. Anesth Analg 1986 65(1) 37-45. 

NTl 77 Matulionis, D. H. Reaction of macrophages to cigarette smoke. I. Recruitment of pulmonary macrophages. Arch Environ Health 1979 34(5) 293-298. 

NT190 Brody, A. R., and J. E. Craighead. Cy-toplasmic inclusions in pulmonary macrophages of cigarette smokers. Lab Invest 1975 32(2) 125-132. 

Pulmonary macrophages cultured in vitro for 20 h with media containing 14.5-58.0 mg Ni/kg as nickel chloride... 

Hsu, I.C., C.C. Harris, M. Yamaguchi, B.F. Trump, and P.W. Schafer. Induction of ouabain-resistant mutation and sister chromatid exchanges in Chinese hamster cells with chemical carcinogens mediated by human pulmonary macrophages. J. Clin. Invest. 64 1245-1252, 1979. 

---