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Psychoactive drugs classes

Interactions of Major Psychoactive Drug Classes with Neuromuscular Systems... [Pg.235]

Table 12.1 is a scorecard indicating the neuromodulatory systems with which some of the major psychoactive drug classes interact. The table indicates that no one drug does it all, and that most are either 5HT-NE enhancers or DA-ACh blockers. Exceptions to the rule do not necessarily prove it. And in the case of the atypical antipsychotics, it is the antagonism to serotonin which may be critical to efficacy. [Pg.235]

Nichols, DE. Differences between the mechanisms of action of MDMA, MBDB, and the classical hallucinogens. Identification of a new therapeutic class Entactogens. J Psychoactive Drugs 18 305-313, 1986. [Pg.26]

The goal of this chapter is to review recent morphologic studies in which current anatomic me ods have been used to characterize the neurotoxic effects of psychoactive amphetamine derivatives. Several strategies combining anatomic with biochemical data have been employed to analyze the effects of selected drugs in this class. These studies show that psychoactive drugs that have selective neurotoxic effects can be useful experimental tools to study the neural mechanisms of elusive brain functions such as affective state control and perceptual integration. [Pg.270]

Many different drug classes have shown to cause hypotension and orthostatic reactions and drugs for cardiovascular conditions, psychoactive medicines and polypharmacy, can all have this side effect (Box 5.15). Among the most frequently used drugs in the elderly are diuretics, ACE-inhibitors, angiotensin II antagonists, calcium channel blockers and antidepressants. [Pg.71]

Discriminative stimulus effect. Rhesus monkeys, trained to discriminate A-9-THC from vehicle in a two-lever drug discrimination procedure, were tested with a variety of psychoactive drugs, including cannabinoids or drugs from other classes. The results indicated that A-9-THC discrimination showed pharmacological specificity, in that none of the noncannabinoid drugs fully substituted for A-9-THC. The classical cannabinoids, A-9-THC and A-8-THC, and the novel cannabinoids, WIN and l-butyl-2-methyl-3-(l-naphthoyl)indole, produced full dose-dependent substitution for A-9-THC in all monkeys. A heptyl indole derivative failed to substitute for A-9-THC, but it also did not displace pH] CP-55,940 from its binding site . ... [Pg.60]

A growing number of drugs are used that affect the many neurotransmitters in the brain benzodiazepines and others act on GABAergic transmission antidepressants, such as monoamine oxidase inhibitors and tricyclic antidepressants, are thought to increase the concentration of transmitter amines in the brain and so elevate mood—these will also act at peripheral nerve terminals, so interactions with them are a combination of peripheral and central actions. Levodopa (L-dopa) increases central as well as peripheral dopamine, and the newer class of psychoactive drugs, the selective serotonin reuptake inhibitors (SSRIs) of which the ubiquitous fluoxetine (Prozac) is best known, act in a similar way on serotonergic pathways. [Pg.273]

Marijuana is unique among the psychoactive drugs, in a class by itself. The chemicals it contains resemble no other drug molecules. Unlike most of the substances discussed in this book, they are insoluble in water but very soluble in oil. Therefore, they are absorbed unevenly w hen eaten, and they stay in the body for a long time because they accumulate in body fai. Marijuana is... [Pg.114]

Unlike most psychoactive drugs and certainly most depressants, GHB increases rather than suppresses dreaming, and the sleep it induces closely resembles natural sleep- It does not pose the risks of other drugs in this class, but users should be aware of the potential dangers of overdoses, especially in situations that require full alertness, such as driving-... [Pg.214]

BDZs are the most widely prescribed class of psychoactive drugs in current therapeutic use, despite the important unwanted side-effects that they produce such as sedation, myorelaxation, ataxia, amnesia, ethanol and barbiturate potentiation, and tolerance. The existence of a new family of ligands with a flavonoid structure was recentlv demonstrated in the... [Pg.566]

Clinical - Several reviews and articles on the nature and therapy of depressive disorders were published in 1968 °- as well as a useful introductory text on clinical psychiatry . Irwin 5 has proposed a rational framework for the clinical evaluation and use of psychoactive drugs. He noted that patients with depression exhibit a wide variety of behaviour and that the different forms of the disease require different classes of drugs. Mendels likewise remarked that "few terms in psychiatry are used with as many different meanings as depression". The importance of using a suitably large sample size in clinical studies of drug evaluation was stressed . The foregoing are a caveat for the interpretation of the clinical reports discussed below. [Pg.16]

Stimulants are a class of psychoactive medications approved by the U.S. Food and Drug Administration (FDA) for use in the treatment of attention-deficit/hyperactivity disorder (ADHD) in children and adolescents and narcolepsy. A hst of available stimulants is shown in Table 6-1. [Pg.171]


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Psychoactive

Psychoactive drugs

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