Pseudotumor cerebri hypertension

Danazol has been associated with several cases of benign intracranial hypertension also known as pseudotumor cerebri. Early signs and symptoms of benign intracranial hypertension include papilledema, headache, nausea, and vomiting, and visual disturbances. Screen patients with these symptoms for papilledema and, if present, advise the patients to discontinue danazol immediately and refer them to a neurologist for further diagnosis and care. 

Intracranial hypertension Danazol has been associated with several cases of benign intracranial hypertension (also known as pseudotumor cerebri) (see Black Box Warning). 

Pseudotumor cerebri Pseudotumor cerebri (benign intracranial hypertension) in adults has been associated with tetracycline use. 

Cardiovascular - Benign intracranial hypertension (pseudotumor cerebri) has been reported rarely. Bulging fontanels, as a sign of benign intracranial hypertension in infants, have been reported rarely. Changes in electrocardiogram (eg, nonspecific ST/T wave changes, bundle branch block) have been reported in association with pulmonary reactions. 

Benign intracranial hypertension (pseudotumor cerebri) occurs rarely. 

Adrenoicorticai insufficiency, increased intracraniai pressure, pseudotumor cerebri, impaired wound heaiing, Cushing s syndrome, HPA suppression, skin uicers, toier-ance, withdrawai, visuai impairment, ocuiar hypertension, cataracts... 

Long-term glucocorticoid treatment can result in papilledema and increased intracranial pressure (the syndrome of pseudotumor cerebri or so-called benign intracranial hypertension ), particularly in children. 

Headache is a common adverse effect of somatropin. It often occurs early in treatment and usually responds to temporary dosage reduction followed by gradual re-esca-lation (1,24). It can be an early indicator of the rare complication pseudotumor cerebri (idiopathic intracranial hypertension), particularly in high-risk groups, such... 

Pseudotumor cerebri Benign intracranial hypertension characterized by headache and blurred vision may occur in adults. Though discontinuation of the drug reverses the condition, it is not clear whether permanent sequelae may occur. 

Pseudotumor cerebri (benign intracranial hypertension) has been linked to lithium in over 30 cases, with headache, papilledema, increased intracranial pressure, reduced vision, and a risk of blindness (201). The condition tends to improve on withdrawal, but surgical intervention may sometimes be necessary. A review of pseudotumor cerebri devoted one paragraph to induction of this condition by lithium and provided six references but no new information (202). 

Intracranial hypertension (pseudotumor cerebri) secondary to the use of many tetracycline analogues can occur in infents and adults. When the antibiotic is discontinued, cerebral fluid pressure and any accompanying visual and ophthalmoscopic changes usually return to normal over days or weeks. Rarely, tetracycline causes blood dyscrasias such as hemolytic anemia, thrombocytopenia, neutropenia, and eosinophilia. 

Drugs That May Cause Intracranial Hypertension (Pseudotumor Cerebri)... 

Benign intracranial hypertension (pseudotumor cerebri) mainly affects babies, especially during the first 3 months of life. Occasionally even older children can be affected, especially when inordinately high doses are used (5). Very rarely, it occurs in adults with renal insufficiency. In infancy, impaired nalidixic acid elimination (due to underdeveloped glucuronidation), overdosage, or prolonged treatment may be responsible. Metabolic acidosis is usually important in adults (6). 

Single cases of benign intracranial hypertension (pseudotumor cerebri), with and without ocular palsy, have been reported (35,36). Uncharacteristic general symptoms, with dizziness, cephalalgia, or drowsiness, are more frequent. 

Nervous system disturbances include fatigue, lassitude, vertigo, sweating, hypesthesia, paresthesia, dizziness, fever, amnesia, delirium, flu-like symptoms, somnolence, pseudotumor cerebri, hyperirritability, sleep disturbance, lethargy, depression (41), and psychological changes. There was a direct correlation between intracranial hypertension and the use of isotretinoin in a retrospective study of spontaneous reports (42). 

Adverse/Toxic Inflammatory bowel disease and pseudotumor cerebri (benign intracranial hypertension) have been associated with isotretinoin therapy. 

Headache is most common side effect severe headache may be sign of pseudotumor cerebri (intracranial hypertension) "ATRA syndrome" pulmonary symptoms (dyspnea, respiratory distress, fever, pleural effusions) low emetogenic potential dry skin and mucous membranes, mucositis bone pain transient elevations in transaminases, bilirubin... 

In a 9-year-old girl recombinant human growth hormone 6 mg/week caused idiopathic intracranial hypertension (pseudotumor cerebri), which was treated with acetazolamide [28 ]. After 4 days the dose was increased to 30 mg/kg/day, and 2 days later she developed a severe metabolic acidosis, with a pH of 7.29. 

Dryness of lips and mucosae are usual but are reversible with symptomatic treatment. Increases in transaminases and triglycerides and bone pain are common, but they never required treatment discontinuation in our experience. Headache, due to intracranial hypertension, is generally moderate in adults but may be severe in children, and associated with signs of pseudotumor cerebri [60]. Lower ATRA doses (25 mg/m /day) reduce this side effect in children and seem as effective as conventional doses of 45 mg/m /day in inducing CR [60]. In our experi-... 

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