UV-Induced Aggregation of Prion Protein

Prion protein aggregates do not show increase in Thioflavin T (ThT) fluorescence, indicating the formation of amorphous aggregates. In order to probe 

exposure to UV light causes perturbation of the N-terminal region of prion protein (which has seven out of eight tryptophans) and leads to amorphous aggregation. Noncovalent interactions play a predominant role in the photo-aggregation of prion protein [3], 

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