Proteins ginseng effects

Ca2+ channels Ginseng extract rapidly and reversibly inhibits high-threshold, voltage-dependent Ca2+ channels in micromolar doses (Nah and McCleskey 1994 Nah et al. 1995). This effect is mediated by a receptor linked to a pertussis toxin-sensitive G protein, but it is not through o2 adrenergic, GABAB, muscarinic, or opioid receptors (Nah and McCleskey 1994). Several ginsenosides inhibit Ca2+ currents by 16 to... 

Chinese hamster ovary cells overexpressing the prolactin receptor, was active . Protein synthesis stimulation. Sterol fraction of the extract, in cell culture at a concentration of 25 (xg/mL, produced weak activity on CA-LNCAP. A concentration of 50 (xg/mL was active on CA-PC3 h PSA production inhibition. Ethanol (70%) extract of PC-SPES (a Chinese herb combination of chrysanthemum, dyers woad, licorice, reishi, san-qi ginseng, rabdosia, saw palmetto, and baikal skullcap), in cultured prostate cancer cell line at variable doses for 24 hours, produced a significant effect in supressing cell growth in all the cell lines h... 

The effect of the major saponin from Panax ginseng (Araliaceae), ginsenoside Rbi (33), was investigated on rat liver protein phosphorylation. It was observed that 118, 63 and 34 kDa proteins were... 

The petroleum ether extract of Panax ginseng has antiproliferative effects on various cancer cell lines (murine sarcoma, murine leukaemia, human colon carcinoma, etc ). Polyacetylenic compounds from this extract such as panaxynol, panaxydol (46) and panaxytriol have been reported to be responsible for these effects [112, 113]. In order to identify the molecular mechanism of the polyacetylene compounds, one of the major cytotoxic compounds, panaxydol, was examined to see if it is able to disrupt cell cycle-related events. It was observed that panaxydol induces cell cycle arrest at Gi-S transition in SK-MEL-1 cells. This effect is related to the decreased Cdk2 activity, which seems to be caused by the increased level of p27 protein expression. The protein synthesis inhibitor cycloheximide reversed the growth suppression induced by panaxydol (80 j,g/ml) by... 

Chikusetsusaponin III (CIII, Fig. (1)) a protopanaxadiol glycoside from Panax ginseng was reported to exhibit an antiviral effect on HSV-1 with a complete elimination of HSV plaque formation at 50 pM. The mechanism of action might be an effect on the later events of virus replication, as CIII exerted marginal effect on the accumulation of viral protein at early times... 

Effects of saponins on nucleic acid biosynthesis and serum protein metabolism have been extensively studied 169 — 182). The presence in Ginseng of substances with adenosine triphosphate activity has been reported 183). Effects by the saponins on cholesterol metabolism and that of other lipids have been described 184 — 188). 

Oura, H., S. Nakashima, K. Tsukada, and Y. Ohta Effect of Radix Ginseng Extract on Serum Protein Synthesis. Chem. Pharm. Bull. (Japan) 20, 980 (1972). 

Nagasawa, T., H. Oura, S. Hiai, and K. Nishinaga Effect of Ginseng Extract on Ribonucleic Acid and Protein Synthesis in Rat Kidney. Chem. Pharm. Bull. (Japan) 25, 1665 (1977). 

Yamamoto, M., A. Kumagai, and Y. Yamamura Stimulatory Effect of Panax ginseng Principles on DNA and Protein Synthesis in Rat Testis. Arzneim. Forsch. (Drug Res.) 27, 1404 (1977). 

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