Protein kinase C modulation

Swartz, K. J., Merritt, A., Bean, B. P., and Lovinger, D. M. (1993) Protein kinase C modulates glutamate receptor inhibition of Ca2+ channels and synaptic transmission. Nature 361,165-168. 

Maduh EU, Baskin SI. 1994. Protein kinase C modulation of rhodanese catalyzed conversion of cyanide to thiocyanate. Res Comm Mol Pathol Pharmacol 86(2) 155-173. 

Matsumoto T, Tani E, Yamaura 1, Miyaji K, Kaba K (1995) Effects of protein kinase C modulators on multidrug resistance in human glioma cells. Neurosurgery 36 565-571... 

Cooper CB, Amot MI, Feng ZP, Jarvis SE, Hamid J, Zamponi GW (2000) Cross-talk between G-protein and protein kinase C modulation of N-type calcium channels is dependent on the G-protein beta subunit isoform. J Biol Chem 275 40777-81 Coppola T, Magnin-Luthi S, Perret-Menoud V, Gattesco S, Schiavo G, Regazzi R (2001) Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin. J Biol Chem 276 32756-62... 

Sutton KG, McRory JE, Guthrie H, Murphy TH, Snutch TP (1999) P/Q-type calcium channels mediate the activity-dependent feedback of syntaxin-lA. Nature 401 800-4 Swartz KJ (1993) Modulation of Ca2+ channels by protein kinase C in rat central and peripheral neurons disruption of G protein-mediated inhibition. Neuron 11 305-20 Swartz KJ, Merritt A, Bean BP, Lovinger DM (1993) Protein kinase C modulates glutamate receptor inhibition of Ca2+ channels and synaptic transmission. Nature 361 165-8 Takahashi SX, Miriyala J, Colecraft HM (2004) Membrane-associated guanylate kinase-like properties of beta-subunits required for modulation of voltage-dependent Ca2+ channels. Proc Natl Acad Sd US A 101 7193-8... 

Cousin MA, McLaughlin M, Nicholls DG (1999) Protein kinase C modulates field-evoked transmitter release from cultured rat cerebellar granule cells via a dendrotoxin-sensitive K+ channel. Eur J Neurosci 11 101-9... 

DiMagno L, Dascal N, Davidson N, Lester HA, Schreibmayer W. Serotonin and protein kinase C modulation of a rat brain inwardly rectifying K+ channel expressed in Xenopus oocytes. Pflugers Arch 1996 431 335-340. 

Chen YH,Tukey RH. 1996. Protein kinase C modulates regulation of the CYP1A1 gene by the aryl hydrocarbon receptor. J. Biol. Chem. 271 26261-66... 

Lan J, Skeberdis VA, Jover T, Grooms SY, Lin Y, et al. 2001. Protein kinase C modulates NMDA receptor trafficking and gating. Nat. Neurosci. 4 382-90... 

Collins GG, Richards WJ. 1990. Pharmacological evidence that protein kinase C modulates monosynaptic excitations in the olfactory cortex. Naunyn Schmiedebergs Arch Pharmacol 341 114-122. 

Corey JL, Davidson N, Lester HA, Brecha N, Quick MW (1994) Protein kinase C modulates the activity of a cloned gamma-aminobutyric acid transporter expressed in Xenopus oocytes via regulated subcellular redistribution of the transporter. J Biol Chem 269 14759-14767. 

Edsall, L.C., Van Brooklyn, J.R., Cuvillier, O., Kleuser, B., and Spiegel, S., N,N-Dimethyl-sphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C modulation of cellular levels of sphingosine 1-phosphate and ceramide, Biochemistry, 37 (1998) 12892-12898. 

Davada, R. K., Chandler, L. J., and Guzman, N. J. (1994). Protein kinase C modulates receptor-independent activation of endothelial nitric oxide synthase. Eur. J. Pharmacol. 

Tanaka T, Ohta H, Kanda K, Tanaka T, Hidaka H, Sobue K (1990) Phosphorylation of high-Mr caldesmon by protein kinase C modulates the regulatory function of this protein on the interaction betvreen actin and myosin. Eur J Biochem 188 495-500 Tanner JA, Haeberle JR, Meiss RA (1988) Regulation of glycerinated smooth muscle contraction and relaxation by myosin phosphorylation. Am J Physiol 255 C34-C42 Tansey MG, Hori M, Karaki K, Kamm KE, Stull JT (1990) Okadaic acid uncouples myosin light chain phosphorylation and tension in smooth muscle. FEBS Lett 270 219-221... 

Shivachar AC, WiUoughby KA, Ellis EF (1995) Effect of protein kinase C modulators on 14,15-ep-oxyeicosatrienoic acid incorporation into astrogUal phospholipids. JNeurochem 65 338 346... 

Protein Kinase C. Figure 1 Domain structure of PKC family members showing regulatory modules (pseudosubstrate sequence and C1, C2, and PB1 domains) and the kinase core. Shown below are the structures of the C1 domain of PKC 5 with bound phorbol (purple), the C2 domain of PKC (3 with bound Ca2+ (pink spheres), and the recently solved structure of the kinase domain by Grant and coworkers [1] of PKC pil with phosphorylation sites indicated in pink. Figure adapted from Newton (2003). 

Developmental exposure to Pb or Mm affect signal transduction process, possibly related to the modulation of nitric oxide as well as alterations in receptor-mediated phosphoinositide hydrolysis and protein kinase C (rats)... 

Deehan, M., Harnett, M. and Harnett, W. (1997) A filarial nematode secreted product differentially modulates expression and activation of protein kinase C isoforms in B lymphocytes. Journal of Immunology 159, 6105-6111. 

Mestek A, Hurley JH, Bye LS et al. The human k opioid receptor modulation of functional desensitization by calcium/cal-modulin-dependent protein kinase and protein kinase C. J Neurosci 1995 15 2396-2406. 

As described in several monographs [4], bryostatin 1 exhibits significant in vitro and in vivo antineoplastic activity against a range of tumor cell lines including murine leukemia, B-cell lymphoma, reticulum cell sarcoma, ovarian carcinoma, and melanoma. It is also effective in the modulation of apoptotic function [5], the reversal of multidrug resistance [6], and stimulation of the immune system [7]. These unique features displayed by bryostatin 1 are attributed to its high affinity for protein kinase C (PKC) isozymes and its ability to selectively modulate their functions [8]. PKCs are a type of intracellular serine and threonine kinase that... 

It has been suggested that tamoxifen, one of the most effective therapeutic and chemopreventive agent for breast cancer, modulates protein kinase C through oxidative stress in breast cancer cells [194], Unfortunately, most breast cancers initially responsive to tamoxifen treatment later become resistant. Schiff et al. [195] suggested that the conversion of breast tumors to a tamoxifen-resistant phenotype is associated with oxidative stress and depends on significantly enhanced SOD activity in tumors. 

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